ID G1NFM6_MELGA Unreviewed; 668 AA.
AC G1NFM6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Nucleoporin NDC1 {ECO:0000256|ARBA:ARBA00017534};
DE AltName: Full=Transmembrane protein 48 {ECO:0000256|ARBA:ARBA00031201};
GN Name=NDC1 {ECO:0000313|Ensembl:ENSMGAP00000011826.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000011826.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000011826.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000011826.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the nuclear pore complex (NPC), which plays a
CC key role in de novo assembly and insertion of NPC in the nuclear
CC envelope. Required for NPC and nuclear envelope assembly, possibly by
CC forming a link between the nuclear envelope membrane and soluble
CC nucleoporins, thereby anchoring the NPC in the membrane.
CC {ECO:0000256|ARBA:ARBA00025441}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004232}. Nucleus, nuclear pore complex
CC {ECO:0000256|ARBA:ARBA00004567}.
CC -!- SIMILARITY: Belongs to the NDC1 family.
CC {ECO:0000256|ARBA:ARBA00005760}.
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DR AlphaFoldDB; G1NFM6; -.
DR Ensembl; ENSMGAT00000012708.2; ENSMGAP00000011826.2; ENSMGAG00000011311.2.
DR GeneTree; ENSGT00390000014590; -.
DR HOGENOM; CLU_027343_0_0_1; -.
DR InParanoid; G1NFM6; -.
DR TreeFam; TF324843; -.
DR Proteomes; UP000001645; Chromosome 10.
DR Bgee; ENSMGAG00000011311; Expressed in thymus and 17 other cell types or tissues.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR019049; Nucleoporin_prot_Ndc1/Nup.
DR PANTHER; PTHR13269:SF6; NUCLEOPORIN NDC1; 1.
DR PANTHER; PTHR13269; UNCHARACTERIZED; 1.
DR Pfam; PF09531; Ndc1_Nup; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nuclear pore complex {ECO:0000256|ARBA:ARBA00023132};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 668 AA; 75109 MW; B7EE51A31F37050B CRC64;
LLLFTPPLPQ VLGWRLAAAV AWSVLLLPVC TAAFVLLSGV QPLRPLRWLS DSFDDLYTSH
VIFCILLMSV VILVISVFNA EFYAVVPSIP CSRLALIGKI IHPQQVIHSV AHAVMGMLVA
WCAAVMTKGR FQFLAVSCTI SESLDDAVPQ MCLNEYHLFF LLSGAFMGYC YSLLYLINNM
NYLPFPIIQQ YKYLRFRRSL PLLIKHSCVE SLYSVRNFCV AYYFFGYIPK MWISTTMDLR
IDSKLHPLDT LSGLLDLSLF YHAWLCGVFL LVTWYIAWLF FKIYATETHH FPVQPTFAEE
TDQCLPKILN SNPPLIIKFL ALQDLMLLSQ YSPVRRQEVF SLSQPGGHPH NWSAISRECL
SLLTDLTQRL IAQQEAAAAN GRAKQQVEEM KVSPQTPGAA GAEDITFQLQ RSNVIPRASM
SSLVKSSSMP LKASPGSDIG SPFSSPALNC KVGILDLNSP WHGKVQSPLI VRRGPKLWTS
GSGLQMNGSH HESFPVLSVA RVGSEAVQPS FIYTWLQNKQ EQIKNFLSRR VLIMYFFSKH
PEASIQAVFS DAQMHIWALE GLSHLVAASF TEDQFGVVQT TLPAILNTLL TLQEVVDRHF
KLPHVSSKPP RSSGSLVDTS YKTLRFALRA SLKTALYRIT TVFGEHLNAV QVSTEHKKRL
QQFLEYKE
//
