ID G1NG00_MELGA Unreviewed; 1316 AA.
AC G1NG00;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=PAS domain-containing protein {ECO:0000259|PROSITE:PS50112};
GN Name=NCOA2 {ECO:0000313|Ensembl:ENSMGAP00000011971.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000011971.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000011971.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000011971.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933}.
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DR Ensembl; ENSMGAT00000012855.3; ENSMGAP00000011971.3; ENSMGAG00000011424.3.
DR GeneTree; ENSGT00950000183021; -.
DR HOGENOM; CLU_001988_0_0_1; -.
DR TreeFam; TF332652; -.
DR Proteomes; UP000001645; Chromosome 3.
DR Bgee; ENSMGAG00000011424; Expressed in proventriculus and 17 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:InterPro.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.140.20; Nuclear receptor coactivator, Ncoa-type, interlocking domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF2; NUCLEAR RECEPTOR COACTIVATOR 2; 1.
DR Pfam; PF07469; DUF1518; 1.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 1.
DR SMART; SM01151; DUF1518; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..66
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 310..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1295..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1316 AA; 142092 MW; 44975E632D7F3D9D CRC64;
MMLEALDGFF FVVNPEGNVV FVSENVTQYL RYNQEELMNT SIYSILHVGD HNEFVKILLP
KSLVNGGSWS GDTPRRNSHT FNCRMLVKPL ADSEEGHDNQ EAHQKYETMQ CFAVSQPNSF
KEDGEDLQSC LICVARRAPM KERPLLPSSE SFTTRQDLQG KITSLDTSSM RAAMKPGWED
LVRRCIQRFH SQHEGEISFA KRHHQEVLRQ GLAFSPVYRF SLSDGTIVSA QTKSKLIRSQ
TTSEPQLVIS LHMLHREQNV CGMNQDLTGQ GMGKILNPIS SSSPAHQAMC SGNPGQDMTI
SSNMNFAING PKEQMGMPAG RFGGSGGMNH VSSIQASTPQ GSNYALKMNS PSQSSPSMNP
GQPNSMLSPR HRVSPGVAGS PRIPPSQFSP AGSLHSPVGV CSSTGNSHNY TNSSLNALQA
LSEGHGVSLG SSLASPDLKM GNLQNSPVNM NPPQLSKMGS LDSKDCFGLY GEQSEGTTGQ
TESSCHSGEQ KDNSESSVPP AVSSERPDGQ NKLHDGKSQT KLLQLLTTKS DQMEPSPLSS
TMGDISKDST GGLPGSGSAH GTSLKEKHKI LHRLLQDSSS PVDLAKLTAE ATGKELNQES
SSTAPGSEVT VKQEPVSPKK NNNALLRYLL DKDDTKDIGL PDIPPKLERL DSKTDPSGST
KLIPMRTEKE EISFEPNEQP GSELDNLEEI LDDLQNSQLP QLFPESRPGA PAGSVDKQAI
INDLMQLTSD SSPGTAVATQ KPAMRISQST FNNPRAGQLG RLLPNQNLPL DITLQNPTGA
GAFPPIRTSS PYSVIPQPGL MGRNEGMIGN QGALGNSSTG MISGSAPRPA MTSGEWGSQA
SAVRVTCAPT ASAMNRPVQA GLIRNPTASI PLRPSNQPGP RQMLPSQVMN MGPSELEMNI
GGPQYSQQQA PPNQTAPWPD SILPIDQATF GGQNRQPFGS SPDDLLCNHP SSESPSDEGA
LLDQLYMALR NFDGLEEIDR ALGIPELVSQ SQAVDPETFP GQDSSMLLEQ KAQVFSQQYT
AQAQMAQGSY APMQDPSFHA MGQRPGYAAL RMQPRPGLRP ASIIQSQPNQ LRLQLQHRLQ
AQQNRQPLIN QMSSVSNMNL SLRPGVPTQG PINAQMLAQR QREILSQHLR QRQMQQQQQV
QQRTLMMRGQ GLSMTPSMVA TGGIPATMSN PRIPQANAQQ FPFPPNYGIS QQPDPGFTGA
TTPQSPLMSP RLAHTQSPMI QQTQANPAYQ SSTEMNGWAQ GNMGGNSMFS QQSPPHFGQQ
ASTSMYNNNM NINVSMATNT SGMNNMNQMT GQISMTSATS VPTSGLSSMG PEQKYC
//
