ID G1NGA2_MELGA Unreviewed; 576 AA.
AC G1NGA2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Deleted in malignant brain tumors 1 protein {ECO:0000256|ARBA:ARBA00014650};
DE AltName: Full=Hensin {ECO:0000256|ARBA:ARBA00030560};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000012098.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000012098.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000012098.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DMBT1 family.
CC {ECO:0000256|ARBA:ARBA00009931}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; G1NGA2; -.
DR Ensembl; ENSMGAT00000012985.3; ENSMGAP00000012098.3; ENSMGAG00000011564.3.
DR GeneTree; ENSGT00950000183145; -.
DR HOGENOM; CLU_024908_0_0_1; -.
DR TreeFam; TF351216; -.
DR Proteomes; UP000001645; Chromosome 8.
DR Bgee; ENSMGAG00000011561; Expressed in duodenum and 11 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR048290; ZP_chr.
DR InterPro; IPR001507; ZP_dom.
DR InterPro; IPR017977; ZP_dom_CS.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR PANTHER; PTHR14002:SF53; ZP DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00530; SRCR; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00258; SPERACTRCPTR.
DR PRINTS; PR00023; ZPELLUCIDA.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00202; SR; 1.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS50287; SRCR_2; 1.
DR PROSITE; PS00682; ZP_1; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 22..122
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 144..253
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 262..508
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT DISULFID 47..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 60..121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 91..101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 576 AA; 64277 MW; 3F618B53BEB87AEC CRC64;
MGACCSVFPS VFLASPFPDA SLSLVNGRNR CEGRVEVYYN GNRGTVCDDS WDINDAEVVC
RQLDCGFAVS APGSAYFGQG SGTIYLDDVQ CTGNESSLFE CRSRGWGVHN CNHYEDASVV
CSAANTSTLI PTPPSSTPAS KYFCGSFLSN SSGTIQSPFY PSNYPDNADC LWEIQVMNNY
RIMLTFGTIR LQGGCQYDYI EIYDGPPSTS PLLGRICSGY NIMYTSSSNM MTVRFHSDSR
YSNRGFYADY HSFPADQNTA LFCFPSHMRA VVERNYLQSQ GYSVWNASLS DPSCRPRITS
TQVIFNIPYN SCGTRRQSNN ETFTYSNVIR VFASDSIIKR KKDLYLHVNC KMLQKTWVQV
MYIADDGGVA NVDETQYGRY KVDFAFYNSS SFLLPVSDFP YYVELNQNLF LQASLRSNDS
NLVLFVDTCV ASPDPNDFTT LTYDLIRSGC VKDPTYSSYY SPYPSVSRFA FNAFSFVNRY
PSVYLQCEMV VCRYGDYSSR CYQGCVNRFR RNAGSSQGKV SVVIGPVQLQ EAPSENRNAG
ECKQLPLVFS VGLCILLCVC MSFQKASSAG LFTTLL
//
