ID G1NGA5_MELGA Unreviewed; 1520 AA.
AC G1NGA5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=DNA topoisomerase II binding protein 1 {ECO:0000313|Ensembl:ENSMGAP00000012102.3};
GN Name=TOPBP1 {ECO:0000313|Ensembl:ENSMGAP00000012102.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000012102.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000012102.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000012102.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_010711241.1; XM_010712939.2.
DR Ensembl; ENSMGAT00000012989.3; ENSMGAP00000012102.3; ENSMGAG00000011549.3.
DR GeneID; 100542278; -.
DR KEGG; mgp:100542278; -.
DR CTD; 11073; -.
DR GeneTree; ENSGT00940000157001; -.
DR HOGENOM; CLU_004165_1_0_1; -.
DR InParanoid; G1NGA5; -.
DR TreeFam; TF326403; -.
DR Proteomes; UP000001645; Chromosome 6.
DR Bgee; ENSMGAG00000011549; Expressed in bursa of Fabricius and 17 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0070532; C:BRCA1-B complex; IEA:Ensembl.
DR GO; GO:0000794; C:condensed nuclear chromosome; IEA:Ensembl.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0140463; F:chromatin-protein adaptor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0140031; F:phosphorylation-dependent protein binding; IEA:Ensembl.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
DR GO; GO:0051276; P:chromosome organization; IEA:Ensembl.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:Ensembl.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:Ensembl.
DR GO; GO:0097681; P:double-strand break repair via alternative nonhomologous end joining; IEA:Ensembl.
DR GO; GO:0097680; P:double-strand break repair via classical nonhomologous end joining; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:1990166; P:protein localization to site of double-strand break; IEA:Ensembl.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:Ensembl.
DR CDD; cd17737; BRCT_TopBP1_rpt1; 1.
DR CDD; cd17731; BRCT_TopBP1_rpt2_like; 1.
DR CDD; cd17718; BRCT_TopBP1_rpt3; 1.
DR CDD; cd17749; BRCT_TopBP1_rpt4; 1.
DR CDD; cd18434; BRCT_TopBP1_rpt5; 1.
DR CDD; cd17727; BRCT_TopBP1_rpt6; 1.
DR CDD; cd17738; BRCT_TopBP1_rpt7; 1.
DR CDD; cd17728; BRCT_TopBP1_rpt8; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 9.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR035960; Secretoglobin_sf.
DR InterPro; IPR049542; TopBP1-like_BRCT0.
DR InterPro; IPR044737; TopBP1_BRCT_1.
DR PANTHER; PTHR13561; DNA REPLICATION REGULATOR DPB11-RELATED; 1.
DR PANTHER; PTHR13561:SF20; DNA TOPOISOMERASE 2-BINDING PROTEIN 1; 1.
DR Pfam; PF00533; BRCT; 4.
DR Pfam; PF12738; PTCB-BRCT; 2.
DR Pfam; PF21298; TopBP1_BRCT0; 1.
DR SMART; SM00292; BRCT; 9.
DR SUPFAM; SSF52113; BRCT domain; 6.
DR SUPFAM; SSF48201; Uteroglobin-like; 1.
DR PROSITE; PS50172; BRCT; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 120..171
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 193..282
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 353..443
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 625..728
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 892..983
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1283..1348
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1387..1484
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 285..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1498..1520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1520 AA; 168433 MW; 8FC4FE145FD29A22 CRC64;
MKGSKELFLV KFVKSSGRSK YFLKALESIK EFQSEEHLQI LEEEAALNIK ENDKSLYICD
PFTGVVFNHL KKLGCRIVGP QVVLYCMQTQ RCVPRAEYPV YNMTMADVTI SCTTLDKDVR
EEVHKYVQMM GGRVYRDLNM SVTHLIAGEV GSKKYLVAAS LKKPILLPSW VKRLWDKSQQ
SMMRYTDVNM EDYTCPVFLG CTICVTGLSS SDRKEVQRLT AEHGGQYSGQ LKMNECTHLI
VQEPKGQKYE CARKWNVHCV PVQWFSDSIE KGFCQDETMY KIETGSKLSS TPSTSTPTSH
ASKLDTHSLS DVSCISNVNL SRVNETACSS AMSSRLDPPP DELENLDISS FQAPEDLLDG
CRVYLCGFSG RKLDKMRRLI NCGGGVRFNQ LNEDVTHIIL GENSDELKHF LDKTLHRPHI
VTAKWLLESF NKGCLCPVEQ YIPQNYQLLV NTVLEQPDAK LVLPKNSSIL KKKAVNVVKL
QKAAEDDFLS QYVSNDSTLV EAEKLASGSF NDVTHVTVQE ENQSSVCNGS LGEPSALGEG
GLFARKRFLL LGFGEEDESC IADLIKEHAG KTVPLQSRII ADYAVVPLLG CSVEPTVGDV
VTNIWLVTCV EQQLLLDPQS NPLFTPVPVM EGVTPLVDCV LSFSQFTGAE RDSLVYLAGL
LGARVQEFFV RKANAKKGMF ASTHLVAKEP DGSKYEAAKK WNLPAVTIAW LLQSARTGKR
ADESKFLVEH AGAEDESSMT KLSKTPPTTK FPDSPERPAY LHKAGKKTAV TPLDINRFQS
KAFQAVISHH IGKAATPPAP GGLLQKEPSL HLDTPSKFLS KDKLFKPSFD VKDALAALET
PGGLGQKNRK LSTPLSEVIG RNLKLALANS TRATGALTAS PQLKAAQPEV EEELKPLTGV
VICVSKKLSK KQSELNAIAA SLGADYRWCF DETVTHFIYK GGPNDNNKEY RSVKERGIHI
VSEHWLLECA QEYKRLPESL FPHTYNPKMS LDISAVQDFR PSSSSKLSPT GKPAEENEII
PVDEYDAEDD LTTDQIKETV GIGEEHIGIS ESKGVLTQAL EMRESFQRQL QEIMSATSIV
KPQGQRGSLS RSSFDSSPAT PDSTRSVRNG RSRALEALRQ SRQALTDINT EPSQSEQIIW
DDPTAREERA RLVSNFQWPN SPSQYTEPAQ SNVNRNMDES AFKGSIADAE IAGIVVPEAG
DGDMIEDLKN PVCRDPETPT KDHLIPTPQA PSIAFPLANP PVAPQPKEKA VIEDEKVDEE
PEKCRKFQLS SLNPQERFDY CHLIEELGGI VLEKQCFDPS CTHIVVGHPL RNEKFLASMA
AGKWVLHRSY LEACRGAGCF VQEEDYEWGS DSILNVLPGI NVNQKKLAVA AVRWRKKIHK
GRQETGITEG AFSGWKVILN VDHTKEAGFR RLLQSGGAKV FSGHSVSFFK EATHLFADFS
KLKPDDTRVN VAEAAAQGVN CLKPEYIADF LIQDPPPPME SYCLPEAEPC FHNSKELGAG
LSQKRKAPGE MSSVKRSRMH
//
