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Database: UniProt
Entry: G1NQ90_MELGA
LinkDB: G1NQ90_MELGA
Original site: G1NQ90_MELGA 
ID   G1NQ90_MELGA            Unreviewed;       975 AA.
AC   G1NQ90;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 42.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 4 {ECO:0000313|Ensembl:ENSMGAP00000015960};
GN   Name=TRPC4 {ECO:0000313|Ensembl:ENSMGAP00000015960};
OS   Meleagris gallopavo (Common turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000015960, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000015960, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000015960}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMGAP00000015960}.
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DR   STRING; 9103.ENSMGAP00000015960; -.
DR   Ensembl; ENSMGAT00000016926; ENSMGAP00000015960; ENSMGAG00000015053.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   InParanoid; G1NQ90; -.
DR   OMA; CILVDHR; -.
DR   OrthoDB; EOG091G029I; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000001645; Chromosome 1.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005901; C:caveola; IEA:Ensembl.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR   GO; GO:0030863; C:cortical cytoskeleton; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR   GO; GO:0045296; F:cadherin binding; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0014051; P:gamma-aminobutyric acid secretion; IEA:Ensembl.
DR   GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005460; TRPC4_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF25; PTHR10117:SF25; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01645; TRPCHANNEL4.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    331    351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    363    384       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    405    423       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    435    455       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    476    497       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    517    542       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    563    583       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    595    617       Helical. {ECO:0000256|SAM:Phobius}.
FT   REPEAT      142    174       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   DOMAIN      142    174       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   COILED      228    255       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   975 AA;  111977 MW;  2D56E6563EC1529D CRC64;
     NMAQFYYKRS VNAPYRDRIP LRIVRAESEL SHSEKAYLNA VEKGDYATVK KALEEAEIYF
     KININCIDPL GRTALLIAIE NENLELIELL LSFNVYVGDA LLHAIRKEVV GAVELLLNHK
     KPSGEKQVPP ILLDKQFSEF TPDITPIILA AHTNNYEIIK LLVQKGVSVP RPHEVRCNCV
     ECVSSSDVDS LRHSRSRLNI YKALASPSLI ALSSEDPFLT AFQLSWELQE LSKVENEFKS
     EYEELSRQCK QFAKDLLDQT RSSRELEIIL NYRDDNSLIE EQSGNDLARL KLAIKYRQKE
     FVAQPNCQQL LASRWYDEFP GWRRRHWAVK MLTCVVIGLL FPVFSVCYLI APKSPLGLFI
     RKPFIKFICH TASYLTFLFL LLLASQHIDR SDVSMQGPPP TIVEWMILPW VLGFIWGEIK
     QMWDGGLQDY IHDWWNLMDF VMNSLYLATI SLKIVAFSKY SGLLPRQSWD MWHPTLVAEA
     LFAIANIFSS LRLISLFTAN SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF
     YYETQETKCK GIRCAEQNNA FSTLFETLQS LFWSIFGLIN LYVTNVQPKH EFTEFVGATM
     FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART KLWMSYFEEG GTLPTPFNVI
     PSPKSLWYLI RWLWRHLCKK KIRRKPESFG TIGRRAADNL RRHHQYQEVM RNLVKRYVAA
     MIRDAKTEEG LTEENFKELK QDISSFRFEV LGLLKGSKLS NVQTPKMNKD ASSLSETEEK
     NESEGNKKGK KKAFSLFDIT TMIHPRSATI ASEAHNVSNG SAMLVSESIK EKQKRVNFVT
     DIKNFGLFHR RSKTNSVEQS TNKIYTVSEE VSRQQAEEQC EKNDELEEGE LTVSCEVNTQ
     SPDEKCMVAE LQNDSNTLDS QDEGSICALE TEKMELQNSE SATPQDQLDK ESDINTNCDG
     KQETIEQGDY VITRL
//
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