ID G1NS07_MELGA Unreviewed; 757 AA.
AC G1NS07;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Threonine synthase N-terminal domain-containing protein {ECO:0000259|Pfam:PF14821};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000016952.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000016952.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000016952.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR604450-51};
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC -!- SIMILARITY: Belongs to the threonine synthase family.
CC {ECO:0000256|ARBA:ARBA00005517}.
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DR AlphaFoldDB; G1NS07; -.
DR Ensembl; ENSMGAT00000017926.3; ENSMGAP00000016952.3; ENSMGAG00000016013.3.
DR GeneTree; ENSGT00940000161144; -.
DR HOGENOM; CLU_015170_3_2_1; -.
DR InParanoid; G1NS07; -.
DR TreeFam; TF329641; -.
DR Proteomes; UP000001645; Chromosome 6.
DR Bgee; ENSMGAG00000016013; Expressed in liver and 18 other cell types or tissues.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00464; SK; 1.
DR CDD; cd01560; Thr-synth_2; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR HAMAP; MF_00109; Shikimate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR000623; Shikimate_kinase/TSH1.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR00260; thrC; 1.
DR PANTHER; PTHR43515; THREONINE SYNTHASE-LIKE 1; 1.
DR PANTHER; PTHR43515:SF1; THREONINE SYNTHASE-LIKE 1; 1.
DR Pfam; PF01202; SKI; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR PRINTS; PR01100; SHIKIMTKNASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR604450-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 265..347
FT /note="Threonine synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14821"
FT MOD_RES 380
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ SEQUENCE 757 AA; 84558 MW; 281C6B621EE9BC2E CRC64;
MFIEELIVIF FFFLNQFSGL TRWLRKKKNK NKNKNQKQQQ KMFHTVQYQP LRLITQNSLS
KICLKLMFSR LVTFERISKS WFSSHSLIGN KNIILMGPPG AGKTTVGRIV GQKLDCPVID
IDDDVLERTW NMSVSEKLQD VGNEQFLEEE GKALLKFSAS GSVISLTGSN PMHTAGMQHV
KRNGIVVYLD VPTMVIMSRL KSMKVDRIVG QGPATSLKDI LQFRKQFYKR WYDVRVLCGG
NMAAEVVAEK VLDAVKRYQN SEVETYVSTR STQNNSHKYF SDVVVGGLAS DGGLFVPERG
LPVLTAEEWQ TLIGATYAER AQVILERCIH PADIPASKLR EIIGTAYGEN FTCSKIAPVR
HLTGNQFLLE LFHGPTASFK DFALQMMPHI FAYCIPRSCN YLVLVATSGD TGSAVLDGFS
RLHDTDKQRI AVMSFFPEDG VSPIQKSQMI GCQKENAWSV GVKSDFDFCQ TAIKKIFTNS
DYTGYLTVEY GTALAAANSI NWARLLPQVV YHASAYLDLV HQGIIIFGDP VDVCIPTGNF
GNILAALYAK MMGIPIRKCI CASNENNVLT DFIRTGIYDL RGRKLVPTFS PAVDILKSSN
LERYLHLIAD GDGQLLIQLY NQLENQGHFQ LQKDLLEKLQ QNLVAGWCSE EDCLAAIHSV
YSTTGYILDT HTAVAKVVAD RLQDRTCPII ISSTAHYSKF APAILRALKI TEIKQNPLSQ
LHLLSSYSPL PPVHWGLLAT LKKNENEGHR VCAADLS
//
