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Database: UniProt
Entry: G1NSI7_MYOLU
LinkDB: G1NSI7_MYOLU
Original site: G1NSI7_MYOLU 
ID   G1NSI7_MYOLU            Unreviewed;       715 AA.
AC   G1NSI7;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-SEP-2017, entry version 38.
DE   SubName: Full=Two pore segment channel 2 {ECO:0000313|Ensembl:ENSMLUP00000000096};
GN   Name=TPCN2 {ECO:0000313|Ensembl:ENSMLUP00000000096};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000096, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000000096, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000000096}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000000096}.
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DR   EMBL; AAPE02035393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02035394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02035395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000000096; -.
DR   Ensembl; ENSMLUT00000000101; ENSMLUP00000000096; ENSMLUG00000000099.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00530000063660; -.
DR   InParanoid; G1NSI7; -.
DR   OMA; SSVIWVN; -.
DR   OrthoDB; EOG091G045K; -.
DR   TreeFam; TF328550; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR   GO; GO:0010506; P:regulation of autophagy; IEA:Ensembl.
DR   GO; GO:0006939; P:smooth muscle contraction; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028798; TPC2.
DR   PANTHER; PTHR10037:SF270; PTHR10037:SF270; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     56     79       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    136    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    191    218       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    267    293       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    514    537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    549    569       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    639    661       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       68    296       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      509    664       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   715 AA;  81620 MW;  36BBB73895C8C941 CRC64;
     QGAEWGPLLG GCGHAAGAEA RRDLCFEQAV IFIEDAIQYR SINHRMDTRS MWLYRWYYSD
     TCQWILGFII FLILFLAFIE TPSSFTSTSD VRYRSKPWNP PCGLTESIEV LCLLGFATDL
     SVKSYLVGWP QFRKSLWLLA YLVVLVVSFV DWMVSLSLVC QEPLRLRRLL RPFFLLQNSS
     MMKKMLKCIR WSLPEMASVV LLLALHLCVF TMLGMLLFTG NKQGDGQDRE RLIYFRDLAE
     SLTSLLVLLT TANNPDVMVP AYSKNRAFAL FFIVFTLIEG SLFLMNLLTA IIYNQFRGYL
     LKSVQASLFW KRLGPGMPTR SSPGWRTEKP TLRVGVKAQD LLQVLQKVQV DSTHKQAIME
     KVRSHGDGLL SADEFQKLFN ELDKSLMKEH PPRPEYQSPF LRVAQFLFGH CYFDYLGNVI
     VLANLVSICV STGVPSGGSP VGHSEIVRHA FLCDSERRGP SGQWGSFEKG LQPSLTKSLL
     KVLEISTLAV YRFPHPGWKP ELRGLLSLWD MVRLVNMLIV FRFLRIIPSM KLMAVVASTI
     LGLIRNMRAF GGILVVVYYV FAIVGINLFR GAIVPPPGNI SLAPNGSAPC GSYEQLEYWA
     NNFDDFAAAL VTLWNVMVVN NWQVFLDAYQ RYSGPWSKIY FVLWWLVSSV IWINLFLALI
     LENFLHKWDR RGELQSRSGD QITAVDLLFR EVLEEPTEEE LMAKLRHHPH LQLCR
//
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