ID G1NU83_MYOLU Unreviewed; 1128 AA.
AC G1NU83;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Catenin delta 2 {ECO:0000313|Ensembl:ENSMLUP00000000769.2};
GN Name=CTNND2 {ECO:0000313|Ensembl:ENSMLUP00000000769.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000769.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000769.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000769.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
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DR EMBL; AAPE02001183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02001184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02001185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02001186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02001187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NU83; -.
DR STRING; 59463.ENSMLUP00000000769; -.
DR Ensembl; ENSMLUT00000000840.2; ENSMLUP00000000769.2; ENSMLUG00000000833.2.
DR eggNOG; KOG1048; Eukaryota.
DR GeneTree; ENSGT00940000154952; -.
DR HOGENOM; CLU_007897_0_0_1; -.
DR InParanoid; G1NU83; -.
DR OMA; GQSFSQX; -.
DR TreeFam; TF321877; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0043204; C:perikaryon; IEA:Ensembl.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR GO; GO:0060997; P:dendritic spine morphogenesis; IEA:Ensembl.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR028435; Plakophilin/d_Catenin.
DR PANTHER; PTHR10372:SF9; CATENIN DELTA-2; 1.
DR PANTHER; PTHR10372; PLAKOPHILLIN-RELATED; 1.
DR Pfam; PF00514; Arm; 4.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT REPEAT 470..503
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 514..557
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 795..832
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..138
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1128 AA; 122885 MW; D5C772B2793E18B5 CRC64;
SYSSAEEQFH WQSQDGQKDI EDELTTGLEL VDSCIRSLQE SGILDPQDYS TSERPSLLSQ
SALQLNSKPE GSFQYPASYH SNQTLALGET APSLPARSTQ ARGAGQSFSQ GTTSRAGHLP
GPEPAPPPPP PPREPFAPSL GSAFPLAEAP PAGVLLLQAQ CCRPRGAAYA APRGSSPKQS
PSRLAKSYST SSPINIVVSS AGLSPIRVTS PPTVQTISSS PIHQLSSTIG TYATLSPTKR
LVHASDQYSK HSQELYATAT LQRPGSLAAG SRASYSSQHG HLGPELRALQ SPEHHIDPIY
EDRVYQKPPM RSLSQSQGDP LPPAHTGTYR TSTVLAPSSP GVDSVPLQRT GSQHGPPNAA
TATFQRASYA AGPASNYADP YRQLQYCPSV ESPYSKSGPT LPPEGTLARS PSIDSIQKDP
REFGWRDPEL PEVIQMLQHQ FPSVQSNAAA YLQHLCFGDN KIKAEIRRQG GIQLLVDLLD
HRMTEVHRSA CGALRNLVYG KANDDNKIAL KNCGGIPALV RLLRKTTDLE IRELVTGVLW
NLSSCDALKM PIIQDTLAVL TNAVIIPHSG WENSPLQDDR KIQLHSSQVL RNATGCLRNV
SSAGEEARRR MRECEGLTDA LLYVIQSALG SSEIDSKTVE NCVCILRNLS YRLAAETSQG
QHMGTDELDG LLCGEAGGKD AESSGCWGKK KKKKKSQDQW DGVGPLPDCA EPPKGIQMLW
HPSIVKPYLT LLSECSNADT LEGAAGALQN LAAGSWKGWA EDVAGMAYAL RSLPEGAPCL
PQWSVYIRAA VRKEKGLPIL VELLRIDNDR VVCAVATALR NMALDVRNKE LIGKYAMRDL
VHRLPGGNNS NNAASKAMSD DTVTAVCCTL HEVITKNMEN AKALRDAGGI EKLVGISKSK
GDKHSPKVVK AASQVLNSMW QYRDLRSLYK KDGWSQYHFV ASSSTIERDR QRPYSSSRTP
SISPVRVSPN NRSASAPASP REMISLKERK TDYESTGSNA TYHGTKGEHT SRKDTMTAQN
TGISTLYRNS YGAPTEDIKH NQVSAQPVPQ EPSRKDYETY QPFQNSTRNY DESFFEDQVH
HRPPASEYTM HLGLKSTGNY VDFYSAARPY SELNYETSHY PASPDSWV
//
