ID G1NU97_MYOLU Unreviewed; 584 AA.
AC G1NU97;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Ankyrin repeat and SOCS box containing 14 {ECO:0000313|Ensembl:ENSMLUP00000000783.2};
GN Name=ASB14 {ECO:0000313|Ensembl:ENSMLUP00000000783.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000783.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000783.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000783.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; AAPE02022424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NU97; -.
DR STRING; 59463.ENSMLUP00000000783; -.
DR Ensembl; ENSMLUT00000000856.2; ENSMLUP00000000783.2; ENSMLUG00000000859.2.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000156550; -.
DR HOGENOM; CLU_023739_1_0_1; -.
DR InParanoid; G1NU97; -.
DR OMA; QGWLPVH; -.
DR TreeFam; TF315127; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03730; SOCS_ASB14; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 7.
DR PROSITE; PS50088; ANK_REPEAT; 8.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT REPEAT 113..145
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 146..178
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 179..211
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 212..244
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 245..277
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 310..342
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 352..377
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 382..414
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 526..573
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 584 AA; 64996 MW; 3E5742F7F5B63D2B CRC64;
MDNYTSDEDL DMDFDTQLII QQSLQDICKP GTAEQAPENE SFLSTDCKKI VETIETGEED
ALLHLTKYGS AFDEADEIGR LPLHKAAVQL NTNILEITLK ASKPSVWEQT THNGETPLFL
AVSNCLLENA TFLLLNGCNP NAKNFEGNSP LLTAVLHDSY DMASLLIRHG ADVNLQCANE
RTALHEAARL GRRDLVKLML VSGAHPDPQS SYGFTPLALA AQSGHTEIME ILLQKGANAR
GQASDSSSIL LEAASGGNPD SVTLLLEYGA DANVPKNSGH LPIHVAADRG HLLALKILIP
VTNFAAIKRS GISPVHCAAA GAHPECLELL IQAGFDVNFM LDQRIRKHYD DQRKSALYFA
VSNGDLSSVK LLLSAGALPN QDPVNCLQIA LRMGNYELIS LLLRHGANVN YFCKVNPLHF
PSALQYTLKD EVMLRMLLNY GYDTERCFDC PHGDKVHRIY DFEGWTSTVI KDTLFCEVIT
LSWLQHLSGK VVRIMLDYVD QVRICSKLKA VLQKQRLWSE IHNILTNPRS LKHLCRLKIR
KCMGRLHLRC PVFMSFLPLP NRLKAYVLYK EYDLYGEGIF TGTW
//
