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Database: UniProt
Entry: G1NUK5_MYOLU
LinkDB: G1NUK5_MYOLU
Original site: G1NUK5_MYOLU 
ID   G1NUK5_MYOLU            Unreviewed;       867 AA.
AC   G1NUK5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 73.
DE   RecName: Full=Protein kinase C-binding protein NELL2 {ECO:0000256|ARBA:ARBA00040506};
DE   AltName: Full=NEL-like protein 2 {ECO:0000256|ARBA:ARBA00042609};
GN   Name=NELL2 {ECO:0000313|Ensembl:ENSMLUP00000000908.2};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000908.2, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000000908.2, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000000908.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AAPE02013344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02013345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02013346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02013347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02013348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G1NUK5; -.
DR   STRING; 59463.ENSMLUP00000000908; -.
DR   Ensembl; ENSMLUT00000000995.2; ENSMLUP00000000908.2; ENSMLUG00000000988.2.
DR   eggNOG; KOG1217; Eukaryota.
DR   GeneTree; ENSGT00810000125439; -.
DR   HOGENOM; CLU_006887_0_0_1; -.
DR   InParanoid; G1NUK5; -.
DR   OMA; CNANTKC; -.
DR   TreeFam; TF323325; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR   GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0071679; P:commissural neuron axon guidance; IEA:Ensembl.
DR   CDD; cd00054; EGF_CA; 3.
DR   CDD; cd00110; LamG; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 6.20.200.20; -; 2.
DR   Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR   Gene3D; 2.10.25.10; Laminin; 6.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR048287; TSPN-like_N.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR   PANTHER; PTHR24042:SF0; PROTEIN KINASE C-BINDING PROTEIN NELL2; 1.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 3.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF00093; VWC; 2.
DR   SMART; SM00181; EGF; 6.
DR   SMART; SM00179; EGF_CA; 5.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00210; TSPN; 1.
DR   SMART; SM00214; VWC; 3.
DR   SMART; SM00215; VWC_out; 2.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 2.
DR   SUPFAM; SSF57603; FnI-like domain; 2.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 6.
DR   PROSITE; PS01187; EGF_CA; 2.
DR   PROSITE; PS01208; VWFC_1; 2.
DR   PROSITE; PS50184; VWFC_2; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          321..380
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   DOMAIN          447..489
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          490..531
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          532..572
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          573..603
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          605..651
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          652..687
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          688..743
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   DOMAIN          748..806
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   COILED          290..317
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   DISULFID        575..585
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        593..602
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   867 AA;  96770 MW;  F11B5175181ACAC6 CRC64;
     RALVSLLRGE GAREVPELSS SSWLVLSLCL SRQAPEIKGG GRWTEQIHAM ESRVLLRTFC
     LILGLGAVWG LGVDPSLQID VLTELELGES TTGVRQVPGL HNGTKAFLFQ DTPRSIKAST
     ATADQFFQKL RNKHEFTILV TLKQTHLNSG VILSIHHLDH RYLELESSGH RNEVRLHYRS
     GSHRPHTEVF PYILADDKWH KLSLAISASH LTLHIDCNKI YERVVEKPST DLPVGTTFWL
     GQRNNAHGYF KGIMQDVQLL VMPQGFIVQC PDLNRTCPTC NDFHGLVQKI MELQDILAKT
     SAKLSRAEQR MNRLDQCYCE RTCTMKGTTY REFESWTDGC KNCTCLNGTI QCETLTCPNP
     DCPLKSALAY VDGKCCKECK SICQFQGRTY FEGERHTVYS SSGVCVLYEC KEQTMKLVES
     SGCPALDCPE SQQITLSHSC CKVCKVGYDF CSERHNCMEN SVCRNLNDRA VCSCRDGFRA
     LREDNAYCED IDECAEGRHY CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECVTNQ
     HNCDENALCF NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV CACPQGFTGP
     SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC EDIDECGTGR
     HSCTNDTICF NLDGGYDCRC PHGKNCTGDC IHDGKIKHNG QIWVLENDRC SVCSCQNGFV
     MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC LHQNGETLYN SGDTWVQSCQ QCRCLQGEVD
     CWPLPCPEVE CEFSVLPEGE CCPRCVTDPC QADTIRNDIT KTCLDEMNVV RFTGSSWIKH
     GTECTLCQCK AEGHVCKMHQ PICGDQL
//
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