ID G1NUP4_MYOLU Unreviewed; 837 AA.
AC G1NUP4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=SLIT and NTRK like family member 4 {ECO:0000313|Ensembl:ENSMLUP00000000950.2};
GN Name=SLITRK4 {ECO:0000313|Ensembl:ENSMLUP00000000950.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000950.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000950.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000950.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLITRK family.
CC {ECO:0000256|ARBA:ARBA00010439}.
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DR EMBL; AAPE02015684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006087829.1; XM_006087767.2.
DR RefSeq; XP_014310439.1; XM_014454953.1.
DR AlphaFoldDB; G1NUP4; -.
DR STRING; 59463.ENSMLUP00000000950; -.
DR Ensembl; ENSMLUT00000001039.2; ENSMLUP00000000950.2; ENSMLUG00000001049.2.
DR GeneID; 102419901; -.
DR KEGG; mlf:102419901; -.
DR CTD; 139065; -.
DR eggNOG; ENOG502QQXQ; Eukaryota.
DR GeneTree; ENSGT00940000160971; -.
DR HOGENOM; CLU_012706_1_0_1; -.
DR InParanoid; G1NUP4; -.
DR OMA; EPSMFIH; -.
DR OrthoDB; 4114137at2759; -.
DR TreeFam; TF326378; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IEA:InterPro.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773:SF3; SLIT AND NTRK-LIKE PROTEIN 4; 1.
DR PANTHER; PTHR45773; SLIT AND NTRK-LIKE PROTEIN 4-RELATED; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00365; LRR_SD22; 3.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..837
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003416971"
FT TRANSMEM 617..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 213..263
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 531..581
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
SQ SEQUENCE 837 AA; 94451 MW; EBDCB753A456E6A2 CRC64;
MFLWLFLILS ALISSTNADS EISVEICNVC SCVSVENVLY VNCEKVSVYR PNQLKPPWSN
FYHLNFQNNF LNILYPNTFL NFSHAVSLQL GNNKLQNIEG GAFLGLSALK QLHLNNNELK
ILRADTFLGI ENLEYLQADY NLIKYIERGA FNKLHKLKVL ILNDNLISFL PDNIFRFASL
THLDIRGNRI QKLPYIGVLE HIGRVVELQL EDNPWNCSCD LLPLKAWLEN MPYNIYIGEA
ICETPSDLYG RLLKETNKQE LCPMGTGSDF DVRILPPSQL ETGYTTPNGH TTQTSFHRLV
TKPPKTTNPS KISGIVAGKA FSNRNLSQIV SYQTRVPPLT PCPAPCFCKT HPSDFGLSVN
CQEKNIQSMS ELIPKPLNAK KLHVNGNSIK DVDISDFAEF EGLDLLHLGS NQITVIKGDV
FHNLTNLRRL YLNGNQIERL YPEIFSGLHN LQYLYLEYNL IKEILAGTFD SLPNLQLLYL
NNNLLKSLPV YIFSGAPLAR LNLRNNKFMY LPVSGVLDQL QSLTQIDLEG NPWDCTCDLV
ALKLWLEKLN DGIVVKELKC ETPVQFANIE LKSLKNEILC PKLLNKPSAP FTSPAPAITF
TTPLGPIRSP PGGPVPLSIL ILSILVVLIL TVFVAFCLLV FVLRRNKKPT VKHEGLGNAE
CGSMQLQLRK HDHKTNKKDG LSTEAFIPQT IEQMSKSHTC GLKESETGFM FSDPPGQKVS
MRNVADKEKD LLHVDSRKRL STIDELDELF PSRDSNVFIQ NFLESKKEYN SIGVSGFEIR
YPEKQDKKNK KSLIGGNHSK IVVEQRKSSE YFELKAKLQS SPDYLQVLEE QTALNKI
//