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Database: UniProt
Entry: G1NWE8_MYOLU
LinkDB: G1NWE8_MYOLU
Original site: G1NWE8_MYOLU 
ID   G1NWE8_MYOLU            Unreviewed;      1053 AA.
AC   G1NWE8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 80.
DE   SubName: Full=Myosin IC {ECO:0000313|Ensembl:ENSMLUP00000001651.2};
GN   Name=MYO1C {ECO:0000313|Ensembl:ENSMLUP00000001651.2};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000001651.2, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000001651.2, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000001651.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, stereocilium membrane
CC       {ECO:0000256|ARBA:ARBA00004289}. Cytoplasm
CC       {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC       ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR   EMBL; AAPE02038119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02038120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02038121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G1NWE8; -.
DR   STRING; 59463.ENSMLUP00000001651; -.
DR   Ensembl; ENSMLUT00000001810.2; ENSMLUP00000001651.2; ENSMLUG00000001803.2.
DR   eggNOG; KOG0164; Eukaryota.
DR   GeneTree; ENSGT00940000157915; -.
DR   HOGENOM; CLU_000192_7_7_1; -.
DR   InParanoid; G1NWE8; -.
DR   OMA; FICRGNC; -.
DR   TreeFam; TF312960; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
DR   GO; GO:0005903; C:brush border; IEA:Ensembl.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR   GO; GO:0031941; C:filamentous actin; IEA:Ensembl.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR   GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0045335; C:phagocytic vesicle; IEA:Ensembl.
DR   GO; GO:0032420; C:stereocilium; IEA:Ensembl.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0071346; P:cellular response to type II interferon; IEA:Ensembl.
DR   GO; GO:0038089; P:positive regulation of cell migration by vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR   GO; GO:1900078; P:positive regulation of cellular response to insulin stimulus; IEA:Ensembl.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl.
DR   GO; GO:1900748; P:positive regulation of vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006612; P:protein targeting to membrane; IEA:Ensembl.
DR   GO; GO:2000810; P:regulation of bicellular tight junction assembly; IEA:Ensembl.
DR   GO; GO:0030050; P:vesicle transport along actin filament; IEA:Ensembl.
DR   CDD; cd01378; MYSc_Myo1; 1.
DR   Gene3D; 1.10.10.820; -; 1.
DR   Gene3D; 1.20.5.190; -; 1.
DR   Gene3D; 1.20.58.530; -; 1.
DR   Gene3D; 6.20.240.20; -; 1.
DR   Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR   Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR010926; Myosin_TH1.
DR   InterPro; IPR036072; MYSc_Myo1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13140; MYOSIN; 1.
DR   PANTHER; PTHR13140:SF255; UNCONVENTIONAL MYOSIN-IC; 1.
DR   Pfam; PF00612; IQ; 2.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF06017; Myosin_TH1; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00015; IQ; 2.
DR   SMART; SM00242; MYSc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50096; IQ; 2.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS51757; TH1; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00782}; Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT   DOMAIN          47..731
FT                   /note="Myosin motor"
FT                   /evidence="ECO:0000259|PROSITE:PS51456"
FT   DOMAIN          868..1049
FT                   /note="TH1"
FT                   /evidence="ECO:0000259|PROSITE:PS51757"
FT   REGION          608..630
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT   BINDING         140..147
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ   SEQUENCE   1053 AA;  121151 MW;  D853AC425A381491 CRC64;
     MALQVELIPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD FVLLENFTSE
     AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYTRQH MERYRGVSFY EVPPHLFAVA
     DTVYRALRTE RRDQAVMISG ESGAGKTEAT KRLLQFYAET CPAPERGGAV RDRLLQSNPV
     LEAFGNAKTL RNDNSSRFGK YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHIF
     YQLLEGGEEE TLRRLGLERN PQSYLYLVKG QCAKVSSIND KNDWKVVRKA LTVINFTEDE
     VEDLLSIVAS VLHLGNLHFA ADEESNAQVT SENQFKYLTR LLGVDGSTFR EALTHRKIIA
     KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVGKINRS LASKDAQSPS WRSTTVLGLL
     DIYGFEVFQH NSFEQFCINY CNEKLQQLFI ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC
     DLVEEKFKGI ISILDEECLR PGEATDLTFL EKLEDTIKHH PHFLTHKLAD QRTRKSLGRG
     EFRLLHYAGE VTYSVTGFLD KNNDLLFRNL KETMCSSENP IMSQCFDRSE LSDKKRPETV
     ATQFKMSLLQ LVEILQSKEP AYIRCIKPND AKQPGRFDEV LIRHQVKYLG LMENLRVRRA
     GFAYRRKYEA FLQRYKSLCP ETWPTWAGRP QDGVAVLVRH LGYKPEEYKM GRTKIFIRFP
     KTLFATEDAL EVRRQSLATK IQASWRGFHW RQKFLRVKRS AICIQSWWRG TLGRRKAAKR
     KWAAQTIRRL IRGFILRHAP RCPENAFFLD HVRTSFLLNL RRQLPRNVLD TSWPIPPPAL
     REASELLREL CMKNMVWKYC RSISPEWKQQ LHQKAVASEI FKGKKDNYPQ SVPRLFISTR
     LGADEISPKV LQALGTEPIQ VRHRGWRHRR PRQLLLTPNA VVIVEDAKVK QRIDYTNLTG
     ISVSSLSDSL FVLHVQREDN KQKGDVVLQS DSYSRRLFSA DRVNNININQ GSITYAGGPG
     RDGIIDFTPG SELLITKAKN GHLAVVAPRL NSR
//
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