ID G1NWF4_MYOLU Unreviewed; 1208 AA.
AC G1NWF4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Mitogen-activated protein kinase kinase kinase 6 {ECO:0000313|Ensembl:ENSMLUP00000001658.2};
GN Name=MAP3K6 {ECO:0000313|Ensembl:ENSMLUP00000001658.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000001658.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000001658.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000001658.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02033968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NWF4; -.
DR STRING; 59463.ENSMLUP00000001658; -.
DR Ensembl; ENSMLUT00000001817.2; ENSMLUP00000001658.2; ENSMLUG00000001811.2.
DR eggNOG; KOG4279; Eukaryota.
DR GeneTree; ENSGT00940000159398; -.
DR HOGENOM; CLU_003687_3_0_1; -.
DR InParanoid; G1NWF4; -.
DR OMA; VEQLLHC; -.
DR TreeFam; TF105115; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06624; STKc_ASK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046873; HisK-N-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR043969; MAP3K_PH.
DR InterPro; IPR025136; MAP3K_TRAF-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11584:SF391; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 6; 1.
DR PANTHER; PTHR11584; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF19039; ASK_PH; 1.
DR Pfam; PF20302; HisK-N-like; 1.
DR Pfam; PF13281; MAP3K_TRAF_bd; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 537..795
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 877..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1082
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 566
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1208 AA; 134687 MW; CB03F57B1E47A992 CRC64;
ADVVVLEVSS SLAQPSLFYH LGVRESFSMT NNVLLCSQED IPDLQALRED IFQKNSDCVG
SYTLIPYVVT ATGRVLCGDV GLLRGLADGL VQPGVGTEAL LTPLVGRFAR LLEAMPTDSC
SGYFRETIRQ DIRQARERFS GQQLREELAR LQRRLDSVEL LSPDIIMNLL LSYRDVQDYS
AIIELVETLQ ALPTCDVAEQ HNVCFHYTFA LNRRNRPGDR EKALAVLLPL VQREGPVAPD
LYCMCGRVYK DMFFSSGFQD AGHREQAYHW YRKAFDVEPS LHSGINAAVL LIAAGQRFED
SEELRLIGMK LGCLLARKGC VEKMQYYWDV GFYLGAQILA NDPIQVALAA EQLYKLNAPI
WYLVSMMETF LLYQHFRPTP EPLGGPPRRA HFWLHFLLQS CQLLKADSPQ GDQCLVLVLE
MNQVLLPAKL EVQGVNPVSA VTLSLLEPET QDLPSSWTFS LPSISGVSAS KRDERCCFLY
ALPPAQDVQL CFPSAGHCQW FCGLIQSLVT NPDPRAPVEE AEGVWEVLEF DYEYTETGER
LVLGKGTYGV VYAGRDRHTR VRIAIKEIPE RDSRFSQPLH EEIALHKRLR HKNIVRYLGS
ASEGGYLKIF MEEVPGGSLS SLLRSVWGPL QDNESTISFY TRQILQGLSY LHDNRIVHRD
IKGDNVLINT FSGLLKISDF GTSKRLAGIT PCTETFTGTL QYMAPEIIDQ GPRGYGKAAD
IWSLGCTVIE MATGHPPFHE LGSPQAAMFQ VGMYKVHPPM PSSLSAEAQA FLLRTFEPDP
RLRASAQALL GDPFLQPALS LPQMPLQPAL FLQLTPPPSP RHSHALRHPL NTRLVPRSAA
SATGTPASSG CLLRARSLSY PCESGLKVKA SAGIQTLGRR VPEEPGAEDS ASPEESSGLS
LLHQESKRRA MLAEVLKQEL PTLAENLWLE QDQEPRLGRN LVEQLLHCLG AHIHTPNRRQ
LAQELRALQG QLRAQGLEPA LLHRPLFAFP DAVKQILRRR QIRPHWMFVL DSLLSRAVRG
ALAVLSPGRP GAEMACLWVR AWPLEAWGTQ MELAGGVVTR PDPGVEKDAV PQRSEESRER
EQSLPPLMVQ LGLLRAETDR LRDVLAEKEW ECRALMQQAL QRVDKEARTC SLASGPPAAR
TVDQGLVQWL QELDVDSGTI QRNQLLNHSF TLHALLTCAT KDDLTYTRIR GGMACRIWRA
ILAQRAGS
//
