ID G1NWS4_MYOLU Unreviewed; 823 AA.
AC G1NWS4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Jade family PHD finger 3 {ECO:0000313|Ensembl:ENSMLUP00000001795.2};
GN Name=JADE3 {ECO:0000313|Ensembl:ENSMLUP00000001795.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000001795.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000001795.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000001795.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPE02033774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006097193.1; XM_006097131.2.
DR AlphaFoldDB; G1NWS4; -.
DR STRING; 59463.ENSMLUP00000001795; -.
DR Ensembl; ENSMLUT00000001972.2; ENSMLUP00000001795.2; ENSMLUG00000001967.2.
DR GeneID; 102441333; -.
DR KEGG; mlf:102441333; -.
DR CTD; 9767; -.
DR eggNOG; KOG0954; Eukaryota.
DR GeneTree; ENSGT00940000158722; -.
DR InParanoid; G1NWS4; -.
DR OMA; MFCDQES; -.
DR OrthoDB; 163389at2759; -.
DR TreeFam; TF316118; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0000123; C:histone acetyltransferase complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:2000278; P:regulation of DNA biosynthetic process; IEA:Ensembl.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:Ensembl.
DR CDD; cd15671; ePHD_JADE; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF27; PROTEIN JADE-3; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 199..249
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 251..365
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..823
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 93152 MW; 3293602ACDCDDC16 CRC64;
MKRRRTFSTS DSSDGSPSTS FTGSRYRNKS KIPNEHKKSA EVFRKDLISA MKLSDSHHIN
PDSYYLFTDT WKEEWEKGVQ VPANPDTLPQ PSLRIIADKV KDVLFTRPRK YIHCSMPENS
ELGYVNIREQ AASVCRYDLD DMDMFWLQSL NEDLKEMGCE PIDENLMEKT IEVLERRCHE
NMKHAIATEE GLGIEYDENV ICDVCRSPES EDGNDMVFCD KCNICVHQAC YGILKVPEGS
WLCRSCVVGV AAQCMLCPKK GGAMKTTRTG TKWAHVSCAL WIPEVSIGCP ERMEPITKIS
HIPPSRWALV CYLCKVKTGA CIQCSVKTCT TAFHVTCAFE HNLEMKTILD EDDEVRFKSF
CLKHSQSRQK LGETEYPRYW AEEQSLAKGD KTSPRAQKLQ ELEEEFYSLV NVKDVSTEMG
LPLLTVDLIY NYWKLKRKSN FNKPLFPPRE DEEKGLVQPK AESIHTRMSM FMHLRQDLER
VRNLCYMITR REKLKLSYNK AQEQIFGLQV QLLNQEAAEG PPLTSALENS LFYPPPRITL
KLKMPRSAPE DCRNSSAETD HGPLSPGSNS PVHSMGSAQV PQESLEMKAK SHPRHPLESN
NHCFLTSLGL SRSESKDPSP AWTTPSPESY QGQSLGKPLV LQAALHGQSL IGNGKKRSRS
KSAKSNGLEG SWSGDSTPKD SSSEMSCGQD SMLSSHLASQ GSFRKPTVEH FSRSFKESTN
RWMRTTGGLQ CYGKPTKNVN PREQLWGKQL ARRSAGKAPY QENDGYCPDL ELSDSEAESD
GNKEKVRVKR EGSGREKPPR ASRRDCRGKR KKTHPRSHSS MQR
//
