ID G1NZA7_MYOLU Unreviewed; 598 AA.
AC G1NZA7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Adenosine deaminase domain containing 2 {ECO:0000313|Ensembl:ENSMLUP00000002786.2};
GN Name=ADAD2 {ECO:0000313|Ensembl:ENSMLUP00000002786.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000002786.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000002786.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000002786.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02014406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NZA7; -.
DR STRING; 59463.ENSMLUP00000002786; -.
DR Ensembl; ENSMLUT00000003066.2; ENSMLUP00000002786.2; ENSMLUG00000003054.2.
DR eggNOG; KOG2777; Eukaryota.
DR GeneTree; ENSGT00940000161900; -.
DR HOGENOM; CLU_005382_4_2_1; -.
DR InParanoid; G1NZA7; -.
DR OMA; AKNFYFK; -.
DR TreeFam; TF315806; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0004000; F:adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR Gene3D; 3.30.160.20; -; 1.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR014720; dsRBD_dom.
DR PANTHER; PTHR10910:SF106; ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 1.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 152..188
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 269..591
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 63336 MW; 58F9919BA35800E6 CRC64;
PASTAPGADD SGRRKLRLAA SLQISPRRPS ASRGQDSWEP PPVPGMEDHE GGGQALASAA
EVGGPLGRAG AGGLGTAQAP EDVGGQMGSF PRVSVPPAGL AGDLTKAARQ LGLQLKDLPP
GQAVALLTQY AANLGVSLIF REDQTADPCF PFSVCAELDG VACPVGIANS KKEAKQQAAL
SALNYIQSQL EGPESPKAPS KPSPPRDLRV ENILTHEQRC AAVVSAGFDR LVNETSPYWA
CKGTVAAVIL EKEVPGARSH TKEIYKLVAL GTGSSSCAGW LEFSGRQLHD CHGLVVARRA
LLRFLYRQLL LATQGGPKGR EQSVLTPQPG PGFPFVLKPR IFIHFYISNT PKGAAHDIYL
PPPATPPPGS FESGLLHSAP FRLQAHIRGE LKPVCYMSPT VRDTHVGCLS ASDKLSRWTV
LGVGGALLAH FLPPLYATSL VLADPCHDPP TLSSAIHTRP NLDRVSGSCL PPPYTRSMLH
LFSGPPVAPL NPTSNTCHDL SLNWSLGDPD IEVVDVTTGR VKADAVPGPP SRLCKAAFLR
AFRQAAQALG KSHLLALKTY EEAKAGPYQE ARQQLSLLLE QQGLGAWPSK PLVGKFRN
//
