ID G1NZD6_MYOLU Unreviewed; 588 AA.
AC G1NZD6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000002819.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000002819.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000002819.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02046472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NZD6; -.
DR STRING; 59463.ENSMLUP00000002819; -.
DR Ensembl; ENSMLUT00000003104.2; ENSMLUP00000002819.2; ENSMLUG00000003089.2.
DR eggNOG; KOG3629; Eukaryota.
DR GeneTree; ENSGT00940000153181; -.
DR HOGENOM; CLU_010252_2_1_1; -.
DR InParanoid; G1NZD6; -.
DR TreeFam; TF342571; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF223; RAL-GDS-RELATED PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 322..587
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 242..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..267
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 65506 MW; 2D1A907EC8ED7ECC CRC64;
LCLCRAPTRD ITEGLVNGFN YSTFLGPGKV HRATDTIQGW TQCAAEFTLR LCEARRLRAL
QKGTLEKVAA SLVPAFPAGN IPHICTLMPI HPAFSRAQWF LDELLTSSYH SSDAIKVFST
SGGTPPHNDR GDTPQEQLAK ATASVMGTWP DRVQYLGQPL IAPWFTLKEA LVLHSRPAPH
PVGLVRSLWV ELAHLEPTEA QWEGEGTAVG EDDWGSGAGV QGVSGARIPL KAVTSFLSVE
MHRKEPAPEP PPELKLTPEP EEGPAPGLEP GPAVVVLEPS GPPALIRIPT TERAPPQTTD
YPRAGTPKHL TREEKLNILT FPPRLVAEQL TAMDVELFKK VLPHQCLGSI WSQRRKPGKE
HVASTVRATV RQFNYVATCV ITTCLGDPSM MAWDRAKVVE HWIKVAKECR LLRNFSSLHA
ILAALQSVAV HRLKKTWGQV SSLSLEDSLK MFTFLVPITR RRNDTESSGE PMSLEEVSHF
PEEGTGQGAR PRPKEEFLES ECVPFLGEYL KELKAMDTLM EDDLEVESDQ LAKKEKVQRV
LEEIVVLQEA AQKYQIEPEE QFRTWFWALK RLSENESYIW SCQLEPQS
//
