ID G1NZM7_MYOLU Unreviewed; 751 AA.
AC G1NZM7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Dynein axonemal heavy chain 11 {ECO:0008006|Google:ProtNLM};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000002925.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000002925.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000002925.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02018083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02018084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02018085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NZM7; -.
DR STRING; 59463.ENSMLUP00000002925; -.
DR Ensembl; ENSMLUT00000003214.2; ENSMLUP00000002925.2; ENSMLUG00000003201.2.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000158880; -.
DR HOGENOM; CLU_000038_1_3_1; -.
DR InParanoid; G1NZM7; -.
DR OMA; ENGRIHN; -.
DR TreeFam; TF343076; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF12; DYNEIN AXONEMAL HEAVY CHAIN 11; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 2..121
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 362..482
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 514..651
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 659..749
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 111..138
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 751 AA; 86186 MW; 815F7664A0A2F5E3 CRC64;
RYIRIGDKEC EFHENFRLLL HTKLANPHYK PELQAQTTLL NFTVTEDGLE AQLLAEVVSI
ERPDLEKFKL LLTKHQNDCK IELKSLEEDL LLRLSAAQGS FLGDTQLVER LETTKATAAE
IEHKVIEAKE NEKKINEARE CYRPGGDTGR FYGMMLIIVM TENYHSLYTP QAFSVLFHRA
MEQADRVGDT QGRVSVLMES ITHAIFLHTS RALFEKDKLT FLSQMAFQIL LRKEEIDPGE
LDFLLRFTVE HTYLSPVDFL TTQSWSAIKA VALMEEFRGI DRDVEGSAKQ WRKWVESECP
EKEKLPQEWK KKSLIQKLII LRAMRPDRMT YALRNFVEEK LGAKYVERTR LDLVKALEES
SPATPVFFIL SPGVDALKDL EVLGDRLGFT MDSGKFHNVS LGQGQEAVAE MALETASQAG
HWVILQNVHL VARWLGTLEK LLERFSQGSH RDYRVFMSAE TAPTPSEHII PQGLLENSIK
ITNEPPTGML ANLHAALYNF DQDTLEVCSK EQEFKSILFA LCYFHACVAG RLRFGPQGWS
RRYPFNPGDL TICADVLYNY LEANPNVPWE DLRYLFGEIM YGGHITDDWD RRLCRVYLEE
FMNPSLIEDE LLLAPGFAAP PNLSDYCGYH QYVEETLPPE SPTLYGLHPN AEIEFLTVTS
NTLFRTLLET QPRKALVSQE LEPSTEDKVK NILDDILEKL PEEFNMAEIM QKTSNRSPYV
LVCFQECERM NLLLREIHVS LQQLDLGLKV S
//
