ID G1NZP3_MYOLU Unreviewed; 589 AA.
AC G1NZP3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Protein phosphatase 1 regulatory subunit 12C {ECO:0000313|Ensembl:ENSMLUP00000002943.2};
GN Name=PPP1R12C {ECO:0000313|Ensembl:ENSMLUP00000002943.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000002943.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000002943.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000002943.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAPE02051967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02051968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02051969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NZP3; -.
DR STRING; 59463.ENSMLUP00000002943; -.
DR Ensembl; ENSMLUT00000003236.2; ENSMLUP00000002943.2; ENSMLUG00000003222.2.
DR eggNOG; KOG0505; Eukaryota.
DR GeneTree; ENSGT00940000161425; -.
DR HOGENOM; CLU_000134_54_0_1; -.
DR InParanoid; G1NZP3; -.
DR OMA; MTDARTW; -.
DR TreeFam; TF105543; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR Gene3D; 6.10.140.390; -; 1.
DR Gene3D; 6.10.250.1820; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR031775; PRKG1_interact.
DR PANTHER; PTHR24179; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12; 1.
DR PANTHER; PTHR24179:SF27; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12C; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF15898; PRKG1_interact; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 490..589
FT /note="cGMP-dependent protein kinase interacting"
FT /evidence="ECO:0000259|Pfam:PF15898"
FT REGION 126..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 494..589
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 128..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 64166 MW; 1FB25EBCA1E8A304 CRC64;
VDVEAAQRAE GELLPHDTKC WAESAMPEAP HPPHRGLLLC MWAAAKGLHP KWMKLLLQAG
YDPELRDGDG WTPLHAAAHW GVEDTCRMQA EHGGGMDSLT HAGQRPCDLA DEEVLSLLEE
LAQKQEDLRN QKAASQSRVP EPQVPSSSKH RRSSVCRLSS REKISLQDLS KERRPGGAGG
PPIRDDDDER EEGPTEPPPA ETRALNGVSS PPPPSPKGPS TSEEVPFSRR FGLQKTGSSG
ALGPADRQGA EGAPGAGLQR SASSSLLEGT ATQAKEPRLA RITPTPSRKV PEPSAPLVGV
TPRKCCSPRS TPPSRIPEPE APGKPAIPAA STAPPADSRD RRRSYQMPVR DEESESQRKA
RSRLMRQSRR STQVVNAHGV VSTQLWVAKS PPGPARIYFP TATARALSTP ASGPPSTTER
SPDGQGQGPQ ASREHRRAGK ERRGPAEGEE AKPADISPES STPKASPSPR RPRALNPEPK
PESEPDGGGF RKLYAELRVE NERLREALTE TTLRLAQLKV ELERATQRQE RFAERPALLE
LERFERRALE HKAAELEEEL KGLSNLRADN QRLKDENAAL IRVISKLSK
//