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Database: UniProt
Entry: G1P1P3_MYOLU
LinkDB: G1P1P3_MYOLU
Original site: G1P1P3_MYOLU 
ID   G1P1P3_MYOLU            Unreviewed;       500 AA.
AC   G1P1P3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 44.
DE   SubName: Full=Lipase G, endothelial type {ECO:0000313|Ensembl:ENSMLUP00000003745};
GN   Name=LIPG {ECO:0000313|Ensembl:ENSMLUP00000003745};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000003745, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000003745, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000003745}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000003745}.
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DR   EMBL; AAPE02009054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006085157.1; XM_006085095.2.
DR   STRING; 59463.ENSMLUP00000003745; -.
DR   Ensembl; ENSMLUT00000004111; ENSMLUP00000003745; ENSMLUG00000004113.
DR   GeneID; 102424168; -.
DR   CTD; 9388; -.
DR   eggNOG; ENOG410IJUA; Eukaryota.
DR   eggNOG; ENOG4111GMM; LUCA.
DR   GeneTree; ENSGT00760000119069; -.
DR   InParanoid; G1P1P3; -.
DR   OMA; LKIKLTW; -.
DR   OrthoDB; EOG091G052B; -.
DR   TreeFam; TF324997; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0004465; F:lipoprotein lipase activity; IEA:InterPro.
DR   GO; GO:0008970; F:phosphatidylcholine 1-acylhydrolase activity; IEA:Ensembl.
DR   GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR   GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   GO; GO:0055091; P:phospholipid homeostasis; IEA:Ensembl.
DR   GO; GO:0032376; P:positive regulation of cholesterol transport; IEA:Ensembl.
DR   GO; GO:0010983; P:positive regulation of high-density lipoprotein particle clearance; IEA:Ensembl.
DR   GO; GO:0050746; P:regulation of lipoprotein metabolic process; IEA:Ensembl.
DR   GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 2.60.60.20; -; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR002330; Lipo_Lipase.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00822; LIPOLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SMART; SM00308; LH2; 1.
DR   SUPFAM; SSF49723; SSF49723; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS50095; PLAT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00709807};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Secreted {ECO:0000256|SAAS:SAAS00439306};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    500       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003417466.
FT   DOMAIN      347    482       PLAT. {ECO:0000259|PROSITE:PS50095}.
FT   ACT_SITE    169    169       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    193    193       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    274    274       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
SQ   SEQUENCE   500 AA;  56522 MW;  FE4870A805BD74B0 CRC64;
     MRSPVLLLCL WSAYCCFAAG GPAPLGPEGP PQDELHEPKD VQVPARPSVR FNLRTSEDAE
     HEGCYLPLGH NQPLEDCGFN MTAKTFFIIH GWAMTGILGE WLYKLVSALR TREREANVVV
     VDWLPLAHQL YTDAVNNTKT VGHSIARMLD WLQEKDGFSL GNVHLIGYSL GAHVAGYAGN
     FVTGTVGRIT GLDPAGPMFE GVDIHSRLSP DDADFVDVLH TYTRTFGLSI GIQMPVGHID
     IYPNGGDFQP GCGLNDVLGS IAYGTIAEGV KCEHQRAIYL FVDSLMNEDK ASFAFQCTDS
     RRFKKGICLS CRKNRCNSIG YNAKRTRHKR NSKMYLKTRA GMPFRVYHYQ MKIHFFSYKN
     TTEIEPTFYV TLYGTSADSQ MLPLEVVERI GLNATNTFLV YTEEDLGDLL KIRLTWKRAP
     QSWYSLWTEF RSYLSRSRKP EQEVNIRRIR VKSGETQRKY AFCAEDPENT SISPGQELWF
     HKCLDSRRIK SGTRQTVELP
//
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