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Database: UniProt
Entry: G1P2Q3_MYOLU
LinkDB: G1P2Q3_MYOLU
Original site: G1P2Q3_MYOLU 
ID   G1P2Q3_MYOLU            Unreviewed;      4888 AA.
AC   G1P2Q3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   30-AUG-2017, entry version 43.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSMLUP00000004153};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSMLUP00000004153};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000004153, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000004153, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000004153}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000004153}.
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DR   EMBL; AAPE02015161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02015162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02015163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02015164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02015165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000004153; -.
DR   Ensembl; ENSMLUT00000004565; ENSMLUP00000004153; ENSMLUG00000004511.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1P2Q3; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 8.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4196   4220       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4429   4449       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4499   4523       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4628   4646       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4689   4710       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4769   4792       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        8     63       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       70    115       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      123    177       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      183    241       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      251    308       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      499    710       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      926   1122       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1274   1482       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3939   3974       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4888 AA;  554294 MW;  FFFF423B284B85E4 CRC64;
     QAAQGGGHRT LLYGHAILLR HSFSGMYLAC LTTSRSQTDK LAFDVGLREH ATGEACWWTI
     HPASKQRSEG EKVRIGDDLI LVSVSSERYL HLSICNANIQ VDASFMQTLW NVHPTCSGSS
     IEEGYLLGGH VVRLFHGHDE CLTIPSTDQN DSQHRRIFYE AGGAGTRARS LWRVEPLRIS
     WSGSNIRWGQ AFRLRHLTTG HYLALTEDQG LLLQDRVKSD TKSTAFSFRA SKEIKEKLDS
     SHKRDIEGMG VPEIKYGDSV CFVQHVASGL WVTYKAQDAK TSRLGPLKRK VILHQEGHMD
     DGLTLQRCQR EESQAARIIR NTTALFSQFV KLLVSYSGNN RTAAPVTLPI EEVLQTLQDL
     IAYFQPPEEE MQHEDKQNKL RSLKNRQNLF KEEGMLALVL TCIDRLNIYN SVAHFAGIAR
     EESGMAWKEI LNLLYKLLAA LIRGNRNNCA QFSNNLDWLI SKLDRLESSS GILEVLHCIL
     IESPEALNLI AEGHIKSIIS LLDKHGRNHK VLDVLCSLCL CNGVAVRANQ NLICDNLLPR
     RNLLLQTRLI NDVTSIRPNI FLGVAEGSAQ YKKWYFELII DQVDPFLTPE PTHLRVGWAS
     SSGYAPYPGG GEGWGGNGVG DDLYSYGFDG LHLWSGRIPR AVASINQHLL KSDDVVSCCL
     DLGVPSISFR INGQPVQGMF ENFNTDGLFF PVVSFSAGVK VRFLMGGRHG EFKFLPPSGY
     APCYEALLPK EKMRLEPVKE YKRDSEGIRD LLGTTQFLSQ ASFTPCPIDT SQVVLPPHLE
     KIRDRLAENI HELWGMNKIE LGWTFGKIRD DNKRQHPCLV EFSKLPETEK NYNLQMSTET
     LKTLLALGCH IAHVNPAAEE DLKKVKLSKN YIMSNGYKPA PLDLSDVKLL PSQEILVDKL
     AENAHNVWAK DRIKQGWTYG IQQDLKNKRN PRLVPYTLLD ERTKKSNRDS LREAVRTFVG
     YGYNIEPSDQ ELADPAVEKV SIDKIRFFRV ERSYAVRSGK WYFEFEVVTG GDMRVGWARP
     GCRPDVELGA DDQAFVFEGS RGQRWHQGSG YFGRTWQPGD VVGCMINLDD ASMIFTLNGE
     LLITNKGSEL AFADYEIENG FVPICSLGLS QIGRMNLGMD ASTFKFYTMC GLQEGFEPFA
     VNMNRDVAMW FSKRLPTFVN VPKDHPQIEV MRIDSTMDSP PCLKVTHKTF GTQNSDASMI
     YLRLSMPVEC HSSFTHSPCL DSDAFQKSVE TDARTTLSNN NSKHLDASKS RLWHFSDGGE
     ETVIQCAAEA PPGASNSARN HVESIQTRNR SQGTRLKNRN SCHPFYYVAL HPEFIGQLPL
     GRGFLLPRPH LPPKNALDFF VKQCYYAIRI FAGQDPSCVW VGWVTPDYHF YSEKFDLNKN
     CTVTVTLGDE RGRVHESVKR SNCYMVWGGD IVATSQRSSR SNVDLEIGCL VDLAMGMLSF
     SANGRELGTC YQVEPNTKVF PAVFLQPTST SLFQFELGKL KTALPLSAAI FKSEEKNPTP
     QCPPRLDVQT IQPVLWSRMP SSFLKVETER VSERHGWVVQ CPEPLQMMAL HIPEESRCVD
     ILELCEQEDL MQFHYHTLRL YSAVCALGNS RVAYALCSHV DLSQLFYAID NKYLPGLLRS
     GFYDLLISIH LANAKERKLM MKNEYIIPIN STTRKIRLYP DKSKRHGLPG VGLRTCLKPG
     FKFSTPCVVM TSEEHQKQSP EIPLDILKTK ALSMLTEAVQ GSGAHIRDPV GGSVEFQFVP
     VLKLIGTLLA MGVFDDDDVR QILLLIDPSV FGEHSGETEE GAEKEEVTQV EEKAVEAGEK
     ASKEAPIKGL LQTRLPESVK LQMCELLSYL CDCELQHRVE AIVAFGDIYV SKLQANQKFR
     YNELMQALNM SAALTARKTK EFRSPPQEQI NMLLNFQLGE NCPCPDEIRE ELYDFHEDLL
     THCGVPLEGE EEEEEDSSWT GKLRALLQKI KGPPKPEKHQ PAVEAERCPT TLKELISQTM
     IRWAQEDQIQ DADLIRMMFN LLRRQYDSIG ELLQALRKTY TISQASVSDT INLLAALGQI
     RCLLSVRMGK EEELLMINGL GDIMNNKVFY QHPNLMRVLG MHETVMEVMV NVLGAEKSQI
     AFPKMVASCC RFLCYFCRIS RQNQKAMFEH LSYLLENSSV GLASPSMRGS TPLDVAASSV
     MDNNELALGL EEPDLEKVVT YLAGCGLQSC PMLLAKGYPD VGWNPIEGER YLSFLRFAVF
     VNSESVEENA SVVVKLLIRR PECFGPALRG EGGNGLLAAM QGAIKISENP ALDLPSQGYK
     REVTEDSEDE EEIVHMGNAI MSFYSALIDL LGRCAPEMHL IQTGKGEAIR IRSILRSLVP
     TEDLVGIISI PLKLPSLNKD GSVSEPDMAA SFCPDHKASM VLFLDRVYGI KDQTFLLHLL
     EVGFLPDLRA SASLDTVSLS TTEAALALNR YICSAVLPLL TRCAPLFAGT EHYTSLIDST
     LQTIYRLSKG RSLTKAQRDT IEECLLAICN HLRPSMLQQL LRRLVFDVPQ LNEYCKMPLK
     LLTSHYEQCW KYYCLPSGWG SYGLAVEEEL HLTEKLFWGI FDSLSHKKYD PDLFRMALPC
     LSAIAGALPP DYLDTRISAT LEKQISVDAD GNFDPKPINT MNFSLPEKLE YIVTKYAEHS
     HDKWACDKSQ SGWKYGISLD ENVKTHPLIR PFKTLTEKEK EIYRWPARES LKTMLAVGWT
     VERTKEAEAL VQQRENEKLR SMSQASQGNS YSPAPLDLCN VALSRELQGM VEVIAENYHN
     IWAKKKKLEL ESKDLGGGSH PLLVPYDTLT AKEKSRDREK AQDLFKFLQV NGIVVSRGMK
     DMELDASSME KRFAYKFLKK ILKYVDSAQE FIAHLEAIVI SGKTERSPHD QEIKFFAKVL
     LPLVDQYFTN HRLYFLSSPL KPLSSSGFAS HKEKEMVASL FCKLAALVRH RISLFGSDST
     TMVSCLHILA QTLDTRTVMK SGSELVKAGL RAFFENAAED LEKTSENLKL GKFTHSRTQI
     KGVSQNINYT TVALLPILTS IFEHVAQHQF GVDLLLGDVQ ISCYHILCSL YSLGTGKNIY
     VERQRPALGE CLASLAAAIP VAFLEPTLNR YNPLSVFNTK TPRERSILGV PDTVEEMCPD
     IPPLERLMKE IHHLAESGAR YTEMPHVIEV ILPMLCNYLS YWWEQGPEHL PPSTGPWCTK
     VTSEHLSVIL GNILKIINNN LGIDEASWMK RIADAVYAQP IISKARPDLL RSHFIPTLEK
     LKKKAVKTVQ EEEQLKADSK GDTQEAELLI LDEFAVLCRD LYAFYPMLIR YVDNNRSNWL
     KSPDAASDQL FRMVAEVFIL WCKSHNFKRE EQNFVIQNEI NNLAFLTGDS KSKMSKAMQV
     KSGGQDQERK KTKRRGDLYS IQTSLIVAAL KKMLPIGLNM CTPGDQELIS LAKSRYSCRD
     TDEEVKEHLR NNLHLQEKSD DPAVKWQLNL YKDVLKSEEP SNPEKTVERV QRISAAVFHL
     EQVEQPLRSK KAVWHKLLSK QRKRAVVACF RMAPLYNLPR HRSINLFLHG YQRFWIETEE
     YSFEERLVQD LAKSPRAEEE EEAEAEKQPD PLHQIVLHFS RNALTERSKL EDDPLYTSYS
     SMMAKSCQNG EDEEEEEDKE KTFEEKEMEK QKTLYQQARL HERGAAEMVL QMISASKGER
     SPMVVETLKL GIAILNGGNA GVQQKMLDYL KEKKDAGFFQ SLSGLMQSCR SVLDLNAFER
     QNKAEGLGMV TEEGTLIVRE RGEKVLQNDE FTRDLFRFLQ LLCEGHNNDF QNFLRTQMGN
     TTTVNIIIST VDYLLRLQES ISDFYWYYSG KDIIDESGQH NFSKALVVTK QIFNSLTEYI
     QGPCIGNQQS LAHSRLWDAV VGFLHVFANM QMKLSQDSSQ IELLKELLDL LQDMVVMLLS
     LLEGNVVNGT IGKQMVDTLV ESSTNVEMIL KFFDMFLKLK DLTSSDTFKE YDPDGKGIIS
     KKEFQKAMEG QKQYTQSEID FLLSCAEADE NDMFNYIDFV DRFHEPAKDI GFNVAVLLTN
     LSEHMPNDSR LKCLLIYFEP YLGRIEIMGG KKIERVYFEI SESSRTQWEK PQVKESKRQF
     IFDVVNEGGE QEKMELFVNF CEDTIFEMQL ASQISESDST DRPEEEEEED EDSSYTLEIE
     GEEEDDKSFE SVSAFAMACA SVKRNVANVL KRVTLKNLRK QYRKVKKMTV KELVKVFFSF
     FWMLFVGLFQ LFFTILGGIF QILWNTVFGG GLVEGAKNIR VTKILGDMPD PTQFGIHDDV
     LEAERAEVTE TGITTELVHF LKGEKGDADI MSDLFGFHSK KEGGSKHGPE VGLGDLSEII
     GKDEPPTLES TVRKKRKVQV RQRTQAAEMK AAHDSEGKVE PEKADMEDGE KEETAGEEQA
     KVLWAEATKK KKRRRGQKVE KPEAFMANFF KGLEIYQTKL LHYLARNFYN LRFLALFVAF
     AINFILLFYK VTEEPLEEEA EDVVNLWHSF SDDDEEEAMV FFVLQESTGY MAPTLRALAV
     IHTIISLVCV VGYCCLKVPL VVFKREKEIA RKLEFDGLYI TEQPSEDDIK GQWDRLVINT
     PSFPNNYWDK FVKRKVINKY GDLYGAERIA ELLGLDKNAL DFSPVEETKA EAASLVSWLS
     SIDMKYHIWK LGVVFTDNSF LYLAWYTTMS ILGHYNNFFF AAHLLDIAMG FKTLRTILSS
     VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDD DEPDMKCDDM MTCYLFHMYV
     GVRAGGGIGD EIEDPAGDPY EMYRIVFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ
     VREDMETKCF ICGIGNDYFD TTPHGFETHT LQEHNLANYL FFLMYLINKD ETEHTGQESY
     VWKMYQERCW DFFPAGDCFR KQYEDQLG
//
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