ID G1P2W8_MYOLU Unreviewed; 376 AA.
AC G1P2W8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=TIA1 cytotoxic granule associated RNA binding protein like 1 {ECO:0000313|Ensembl:ENSMLUP00000004227.2};
GN Name=TIAL1 {ECO:0000313|Ensembl:ENSMLUP00000004227.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000004227.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000004227.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000004227.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPE02037778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02037779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P2W8; -.
DR STRING; 59463.ENSMLUP00000004227; -.
DR Ensembl; ENSMLUT00000004645.2; ENSMLUP00000004227.2; ENSMLUG00000004645.2.
DR eggNOG; KOG0148; Eukaryota.
DR GeneTree; ENSGT00940000160482; -.
DR HOGENOM; CLU_025000_2_0_1; -.
DR InParanoid; G1P2W8; -.
DR OMA; YDMVVAQ; -.
DR TreeFam; TF312915; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IEA:Ensembl.
DR GO; GO:0140517; F:protein-RNA adaptor activity; IEA:Ensembl.
DR GO; GO:0007281; P:germ cell development; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0035332; P:positive regulation of hippo signaling; IEA:Ensembl.
DR GO; GO:2000637; P:positive regulation of miRNA-mediated gene silencing; IEA:Ensembl.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0017145; P:stem cell division; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR CDD; cd12616; RRM1_TIAR; 1.
DR CDD; cd12617; RRM2_TIAR; 1.
DR CDD; cd12620; RRM3_TIAR; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR034492; TIAR_RRM1.
DR InterPro; IPR034494; TIAR_RRM2.
DR InterPro; IPR034496; TIAR_RRM3.
DR PANTHER; PTHR10352; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G; 1.
DR PANTHER; PTHR10352:SF82; FI04408P; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SMART; SM00361; RRM_1; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 10..86
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 98..176
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 206..278
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 347..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 41695 MW; 1496719DE1AC34AB CRC64;
TSNIKGYPFT IRYVGNLSRD VTEVLILQLF SQIGPCKSCK MITEHTSNDP YCFVEFYEHR
DAAAALAAMN GRKILGKEVK VNWATTPSSQ KKDTSNHFHV FVGDLSPEIT TEDIKSAFAP
FGKISDARVV KDMATGKSKG YGFVSFYNKL DAENAIVHMG GQWLGGRQIR TNWATRKPPA
PKSTQENNTK QLRFEDVVNQ SSPKNCTVYC GGIASGLTDQ LMRQTFSPFG QIMEIRVFPE
KGYSFVRFST HESAAHAIVS VNGTTIEGHV VKCYWGKESP DMTKNFQQVD YSQWGQWSQV
YGNPQQYGQY MANGWQVPPY GVYGQPWNQQ GFGVDQSPSA AWMGGFGAQP PQGQAPPPVI
PPPNQAGYGM ASYQTQ
//
