ID G1P4F6_MYOLU Unreviewed; 878 AA.
AC G1P4F6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Calsyntenin 2 {ECO:0000313|Ensembl:ENSMLUP00000004839.2};
GN Name=CLSTN2 {ECO:0000313|Ensembl:ENSMLUP00000004839.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000004839.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000004839.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000004839.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004614}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004614}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00035006}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00035006}.
CC -!- SIMILARITY: Belongs to the calsyntenin family.
CC {ECO:0000256|ARBA:ARBA00035015}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPE02006202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02006203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02006204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02006205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02006206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P4F6; -.
DR STRING; 59463.ENSMLUP00000004839; -.
DR Ensembl; ENSMLUT00000005302.2; ENSMLUP00000004839.2; ENSMLUG00000005298.2.
DR eggNOG; KOG1834; Eukaryota.
DR GeneTree; ENSGT00950000183086; -.
DR HOGENOM; CLU_008904_0_0_1; -.
DR InParanoid; G1P4F6; -.
DR OMA; HMVIQPQ; -.
DR TreeFam; TF315946; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:Ensembl.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019894; F:kinesin binding; IEA:InterPro.
DR GO; GO:0042988; F:X11-like protein binding; IEA:InterPro.
DR GO; GO:0008306; P:associative learning; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:1904862; P:inhibitory synapse assembly; IEA:Ensembl.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR GO; GO:0050806; P:positive regulation of synaptic transmission; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 2.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 2.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR026914; Calsyntenin.
DR InterPro; IPR045588; CLSTN_C.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR PANTHER; PTHR14139; CALSYNTENIN; 1.
DR PANTHER; PTHR14139:SF3; CALSYNTENIN-2; 1.
DR Pfam; PF00028; Cadherin; 1.
DR Pfam; PF19699; CLSTN_C; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 2.
DR SUPFAM; SSF49313; Cadherin-like; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50268; CADHERIN_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00043};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 754..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..86
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 87..206
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 812..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..848
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 878 AA; 98410 MW; FF96F26001F09B73 CRC64;
PSAGEICAFK IHGQELPFEA VVLNKTSGEG RLRAKSPIDC ELQKEYTFII QAYDCGAGPR
ETAWKKSHKA VVHIQVKDVN EFAPAFKEPA YKAVVTEGKI YDSILQVEAV DEDCSPQYSQ
ICNYEIVTTD VPFAIDRNGN IRNTEKLSYD KQHQYEILVT AYDCGQKPAA QDTLVQVDVK
PVCKPGWQDW TKRIEYQPGS GSVPLFPSIH LETCDGAVSS IQITTELQTN YIGKGCDRET
YSEKSLQKLC GASSGIIDLL PSPSAASNWT AGLLVDSSEM IFKFDGRQGA KVPDGIVPKN
LTDQFTITMW MKHGPSPGVR AEKETILCNS DKTEMNRHHY ALYVHNCRLV FLLRKDFDQA
DTFRPAEFHW KLDQICDKEW HYYVINVEFP VVTLYMDGAT YEPYLVTNDW PIHPSHIAMQ
LTVGACWQGG EVTKPRFAQF FHGSLASLTI RPGKMESQKV ISCLQACKEG LDINSLESLG
QGIKYHFNPS QSVLVMEGDD IGNINRALQK VSYINSRQFP TAGVRRLKVS SKVQCFGEDV
CISIPDMDAY VMVLQAMEPQ ITLHGTDRLW RPAAQFQSAR GVTLFPDIKI VSTFAKAEAP
GDLKPTAPKS AVLEEMLHNL DFCDILVLGG DLDPRQECLE LNHSELHQRH LDATNSTAGY
SIYGVGSMSR YEQVLRHIRY RNWRPASLES RRFRIKCSEL NGRYTSNEFN LEVSLLHEVR
VSDNEHVNHL IVQPPFLQSV HHPEAQTSVQ RSSVVPSIAT VVVIISVCML VFVVAMGVHR
VRVAHQHFTQ ETEAAKEVEM DWDDSALTIT VNPMEKHEAP GHREDETEEE VEEDISSSSS
DSDASDEEEV EGGVGRGRQG QSGARQAQLE WDDSTLPY
//
