ID G1P6Q7_MYOLU Unreviewed; 758 AA.
AC G1P6Q7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Sphingosine kinase 2 {ECO:0000313|Ensembl:ENSMLUP00000005762.2};
GN Name=SPHK2 {ECO:0000313|Ensembl:ENSMLUP00000005762.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000005762.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000005762.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000005762.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02055571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02055572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P6Q7; -.
DR STRING; 59463.ENSMLUP00000005762; -.
DR Ensembl; ENSMLUT00000006310.2; ENSMLUP00000005762.2; ENSMLUG00000006313.2.
DR eggNOG; KOG1116; Eukaryota.
DR GeneTree; ENSGT00940000161197; -.
DR HOGENOM; CLU_013399_1_1_1; -.
DR InParanoid; G1P6Q7; -.
DR OMA; MPIHRTC; -.
DR TreeFam; TF354296; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000786; C:nucleosome; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017050; F:D-erythro-sphingosine kinase activity; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0008481; F:sphinganine kinase activity; IEA:Ensembl.
DR GO; GO:0038036; F:sphingosine-1-phosphate receptor activity; IEA:Ensembl.
DR GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:1904628; P:cellular response to phorbol 13-acetate 12-myristate; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0090280; P:positive regulation of calcium ion import; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl.
DR GO; GO:0002720; P:positive regulation of cytokine production involved in immune response; IEA:Ensembl.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0033008; P:positive regulation of mast cell activation involved in immune response; IEA:Ensembl.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IEA:Ensembl.
DR GO; GO:0090037; P:positive regulation of protein kinase C signaling; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:2001169; P:regulation of ATP biosynthetic process; IEA:Ensembl.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:1903426; P:regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
DR GO; GO:0006669; P:sphinganine-1-phosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0046512; P:sphingosine biosynthetic process; IEA:Ensembl.
DR GO; GO:0045815; P:transcription initiation-coupled chromatin remodeling; IEA:Ensembl.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR PANTHER; PTHR12358:SF40; SPHINGOSINE KINASE 2; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 234..381
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 57..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..535
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 80094 MW; C5232A51DEFCBAFB CRC64;
MFACLGVDPP GCWLSCPTDA FPAATGSPHT CLGLSVCGAP VIVPHCLSLS AGPAHFPPPD
VGDSDSCPSF PQTPDQELSW SWGPRLRTVQ DRAGAMAPPP PSPLATSTPL LHGEFGSYPA
RGTRFALTLT PQALHIQRLP PKPEARPRGL VLLAEVSGCC TLRSRSPSDP APYLCIYTYP
RAEKATNFTM SPSPRHDAPY SSASCRLERS RGLSSLTSTT SFPLSEETHP HSLARPPDLL
LLVIPFRGKS PAKLCKNHVL PIFSEAGLSF TLIQTAERQN HARELVQGLS LSEWDGIVTV
SGDGLLYEVL NGLLDRPDWE EAMKTPVGIL PCGSGNALAG AVNQHGGFEQ ALGIDLLLNC
SLLLCRGGCR PLDLLSVTLA SGSRCFSFLS VAWGFVSDVD IQSERFRALG SARFTLGTVL
GLATLHTYRG RISYLPATVE PASPAPAHGL PRAKSELTLA PVPARTVAHS PLHRSVSDLP
LSLPQPALTS PDSPEPLPVL SLNGGGPELA RDWGGAGDPP LSPDPLLPSP PGSPRSALLS
PITEGAPEMP ASSGLLPPTP DGDPVAISTG GPPDHLLPPL GTPLPPGWVT LEGDFVLMLA
ISPSHLGADL LAVPNARFDD GLVHLCWVRG GISRAALLRL FLAMERGSHF SLGCPQLGYA
AARAFRLEPL TPRGVLTVDG EQVEYGPLQA QVHPGLAPWE GSESALAAAP AFHGPEPRRT
HRPRPVCPGA RELPPPHDSW LWGYQDLFRI VLTEAVGG
//
