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Database: UniProt
Entry: G1P701_MYOLU
LinkDB: G1P701_MYOLU
Original site: G1P701_MYOLU 
ID   G1P701_MYOLU            Unreviewed;      4909 AA.
AC   G1P701;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   20-DEC-2017, entry version 49.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMLUP00000005869};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000005869, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000005869, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000005869}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000005869}.
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DR   EMBL; AAPE02047096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02047097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02047098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02047099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000005869; -.
DR   Ensembl; ENSMLUT00000006426; ENSMLUP00000005869; ENSMLUG00000006377.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1P701; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4219   4238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4439   4459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4516   4535       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4652   4673       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4710   4731       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4786   4809       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       57    112       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      119    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    229       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      235    298       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      300    357       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      548    758       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      976   1173       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1308   1513       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3962   3997       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3259   3279       {ECO:0000256|SAM:Coils}.
FT   COILED     4357   4377       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4909 AA;  556456 MW;  D08889EAE8CA3230 CRC64;
     STQNVPPDLS ICTFVLEQSL SVRALQEMLA NTMEKSEGKV DVEKWKFMMK TAQGGGHRTL
     LYGHAILLRH SNSGMYLCCL STSRSSTDKL AFDVGLQEDT TGEACWWTIH PASKQRSEGE
     KVRVGDDLIL VSVSSERYLH LSYGSGSSSL HVDAAFQLTL WSVAPISSGS EAAQGYLIGG
     DVLRLLHGHM DECLTVPSGE HGEEQRRTVH YEGGAVSVHA RSLWRLETLR VAWSGSHIRW
     GQPFRLRHVT TGKYLSLMED KNLLLMDKEK ADVKSTAFTF RSSKEKLDAG VRKEVDGMGT
     SEIKYGDSVC YIQHVNTGLW LTYQAVDVKS VRMGAIQRKA IMHHEGHMDD GINLSRSQHE
     ESRTARVIRS TVFLFNRFIR GLDALGRKAK APPVDLPIES VSLSLRDLIS YLHPPAEHLE
     HEDRQNRLRA LKNRQNLFQE EGMISLVLQC VDRLHVYSSA AHFAEVAGRE AGEAWKSILN
     SLYELLAALI RGNRKNCAQF SGSLDWLVSR LERLEASSGI LEVLHCVLVE SPEALNIIKE
     GHIKSIISLL DKHGRNHKVL DVLCSLCVCH GVAVRSNQHL ICDNLLPGRD LLLQTRLVNH
     VSSMRPNIFL GVSEGSAQYK KWYYELMVDH TEPFVTAEAT HLRVGWASTE GYSPYPGGGE
     EWGGNGVGDD LFSYGFDGLH LWAGCIASTV SSPNQHLLRT DDVISCCLDL SAPSISFRIN
     GQPVQGMFEN FNIDGLFFPV VSFSAGIKVR FLLGGRHGEF KFLPPPGYAP CYEAVLPKEK
     LKVEHSREYK QERTYTRDLL GPTVALTQAA FTPVPVDTSQ IVLPPHLERI REKLAENIHE
     LWVMNKIELG WQYGPVRDDN KRQHPCLVEF SKLPEQERNY NLQMSLETLK NCSLKGCCVA
     LCCSQGAEIV SVKMTLVKHF YQLTSGYKPA PMDLSFIKLT PSQEAMVDRL AENAHNVWAR
     DRIRQGWTYG IQQDVKNRRN PRLVPYTLLD DRTKKSNKDS LREAVRTLLG YGYSLEAPDQ
     DHAARAEVCS SPGERFRIFR AEKTYAVKAG RWYFEFEAVT AGDMRVGWSR PGCQPDQELG
     CDEHAFAFDG FKAQRWHQGN EHYGRSWQAG DVMGCMVDMT ERTMMFTLNG EILLDDSGSE
     LAFKDFDVGD GFIPVCSLGV AQVGRMNFGK DVSTLKYFTI CGLQEGYEPF AVNTNRDITM
     WLSKRLPQFL QVPSNHEHIE VTRIDGTADS SPCLKVTQKS FSSQNSSTDI MFYRLSMPIE
     CAEVFSRTAA GGLPGAGLFG PKSDLEDYDV DSDFEVLMKT AHGHLVPDRV DKDKEATKPE
     FNNHKDYAQE KPSRLKQRFL LRKTKPDYST SHSARLTEDV LADDRDDYEY LMQTSTYYYS
     VRIFPGQEPA SVWVGWVTAD FHQYDTCFDL DRVRTVTVTL GDEKGKVHES IKRSNCYMVC
     AGESMSPGQV RNSNGLEIGC VVDAASGLLT FTANGKELST YYQVEPSTKL FPAVFAQATS
     PNVFQFELGR IKNVMPLSAG LFKSEHRNPV PQCPPRLHVQ FLSHVLWSRM PNQFLKVDVS
     RVSERQGWLV QCVDPLQFMS LHIPEENRSA RPWTSLELTE QEELLRFHSH TLRLYSAVCA
     LGNHRVAHAL CSHVDEAQLL YAIESKYMPG LLRTGYYDLL IDIHLSAYAT ARLMMNNEFI
     VPMTEETKSI TLFPDKHKEH GLPGIGLSTS LRPRMRFSSP SFVCLNHDCY QYSPEFPLDT
     LKAKTMQMLT EVVQEGGLRA RDPVGGTTEF LFVPLIKLFY TLLTMGVFQG EDLKHILQLI
     EPRVFKEASL EEEHQAPLKE PHTEDARPEG IRGDAAEGLL QMKLPEPVKL QMCLLLQYLC
     DCQVRHRIEA IVAFSDDFVA RLQDNQRFRY NEVMQALNMS AALTARKTKE FRSPPQEQFI
     LIRRIKALPC VLSQLMNEEP LNDCRIELDD DGSLDGSSDL TIRGRLLSLV EKVTSLKKKQ
     ADKPAESDSD KSSTLQQLIS ETMVRWAQES VIEDPELVRA MFVLLHRQYD GIGGLVQALP
     KTYTISAVSV EDTINLLASL GQIRSLLSVR MGREEEKLMI RGLGDIMNNK VFYQHPNLMR
     ALGMHETVME VMVNVLGGGE SKEITFPKMV ANCCRFLCYF CRISRQNQKA MFDHLSYLLE
     NSSVGLASPA MRGSTPLDVA AASVMDNNEL ALALREPDLE KVVRYLAGCG LQSCPMLVAK
     GYPDIGWNPV EGERYLDFLR FAVFCNGESV EENANVVVRL LIRRPECFGP ALRGEGGNGL
     LAAMEEAIKI AEDPSRDGPS QPAGPAKPRD TEEEDNTIHM GNAIMTFYAA LIDLLGRCAP
     EMHLIHAGKG EAIRIRSILR SLIPLGDLVG VISITFQMPA IAKDGNVVEP DMSAGFCPDH
     KAAMVLFLDR VYGIEVQDFL LHLLEVGFLP DLRAAASLDT AALSATDMAL ALNRYLCTAV
     LPLLTRCAPL FAGTEHHASL IDSLLHTVYR LSKGCSLTKA QRDSIEVCLL SICGQLRPSM
     MQHLLRRFVF DVPLLNEHAK MPLKLLTNHY ERCWKYYCLP GGWGNFGAAS EEELHLSRKL
     FWGIFDALSQ KKYEQELFKL ALPCLSAVAG ALPPDYMESN HVGMMEKQSS MDSEGNFNPQ
     PVETSNITIP EKLEYFINKY AEHSHDRWSM DKLANGWIYG ETYSDSSKVQ PLMKPYKLLS
     EKEKEIYRWP IKESLKTMLA WGWRIERTRE GDSMALYHRT RRISQTSQVS VDAAHGYSPR
     AIDMSNVTLS RDLHAMAEMM AENYHNIWAK KKKMELESKG GGNHPLLVPY DTLTAKEKAK
     DREKAQDILK FLQINGYAVS RGFKDLELDA PTIEKRFAYS FLQQLIRYVD EAHQYILEFD
     GGSRGKGQRF PYEQEIKFFA KVVLPLIDQY FKNHRLYFLS AASRPLCSGG HASNKEKEMV
     TSLFCKLGVL VRHRISLFGN DAASIVNCLH ILGQTLDART VMKTGLESVK GALSAFLDSA
     AEDLDRTLEN LKEGQFTHTR SQPRGVTQII NYTTVALLPV LSSLFEHIGQ HQFGEDLILE
     DVQVSCYRIL TSLYALGTSK SIYVERQRSA VGECLAAFAG AFPVAFLETH LNKHNSCSIY
     NTSSSRERAA LNLPANVEDV CPNIPSLEKL MEEIVELAES GIRYTQMPHV MEVILPMLCS
     YMSRWWEQGP ESNPERAGLC CTALNSEHMN TLLGNILKII YNNLGIDEGA WMKRLAVFSQ
     PIINKVKPQL LKTHFLPLME KLKKKAAMVV SEEDHLKAEA RGDMSEAELL ILDEFTTLAR
     DLYAFYPLLI RFVDYNRAKW LKEPSPEAED LFRMVAEVFI YWSKSHNFKR EEQNFVVQNE
     INNMSFLISD TKSKMSKAAV SDQERKKMRR KGDRYSVQTS LIVAALRRLL PIGLNICAPG
     DQELIALAKN RLSMKDTEDE VRDIIRSNIH LQGKLEDPAI RWQMALYKDL PNRPEDSADP
     EKTVERVLDI ASVLFHLEQK STCMRWRCYS MVEHPQRSKK AVWHKLLSKQ RKRAVVACFR
     MAPLYNLPRH RAVNLFLQGY EKSWIETEEH YFEDKLIEDL AKPGADPPEE DEGTKRVDPL
     HQLILLFSRT ALTEKCKLEE DFLYMAYADI MAKSCHDEDD DDSEEEVKSF EEKEMEKQKL
     LYQQARLHER GAAEMVLQTI SASKGETGPM VAATLKLGIA ILNGGNSTVQ QYVCQLYNVL
     PVEPTMAHIG LHRGQFSHCS VLDLNAFERQ NKAEGLGMVT EEGSGEKVLQ DDEFTCDLFR
     FLQLLCEGHN SDFQNYLRTQ TGNNTTVNII ISTVDYLLRV QESISDFYWY YSGKDVIDEQ
     GQRNFSKAIQ VAKQVFNTLT EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF AHMQMKLSQD
     SSQIELLKEL MDLQKDMVVM LLSMLEGNVV NGTIGKQMVD MLVESSNNVE MILKFFDMFL
     KLKDLTSSDT FKEYDPDGKG VISKRDFHKA MESHKHYTPS ETEFLLSCAE TDENETLDYE
     EFVKRFHEPA KDISFNVAVL LTNLSEHMPN DSRLQTFLEL AESVLRYFQP FLGRIEIMGS
     AKRIERVYFE ISESSRTQWE KPQVKESKRQ FIFDVVNEGG EKEKMELFVN FCEDTIFEMQ
     LAAQISESDL SERSASKEES EKEKPEEQSP RTGFFSLLTV RSALLALRHN LLTLLRMLSL
     KSLKKQMKKV KKMTVRDMVT ALFSSYWGAL ASLLHVVASV LRGFSRIVGS LLLGGSLVEG
     AKKIRVAELL ADMPDPTQDE VRDDGEEGER KPLEAALPSE DLTDLKELTE ESDLLSDIFG
     LDLKREGGQY RLMPHNPNAG LSDLMSNPDP VPEAPEKVQE QETKEEEKEE KEENRSEPEK
     AEGEDGEKEE KAKDEKGRQK LRLIHTHRYG EPEAPESVFW KKIIAYQQKL LNYFARNFYN
     MRMLALFVAF AINFILLFYK VSTSSVVEGK ELPPRSASES ARVSSPDDGG EDAPGVLAVH
     YVLEESSGYM EPTLRILAVL HTVISFFCII GYYCLKVPLV IFKREKEVAR KLEFDGLYIT
     EQPSEDDIKG QWDRLVINTQ SFPNNYWDKF VKRKVMDKYG EFYGRDRISE LLGMDKAALD
     FSDAREKKKP KKDSSLAAVL NSIDVKYQMW KLGVVFTDNS FLYLAWYMTM SVLGHYNNFF
     FAAHLLDIAM GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF FRKFYNKSED
     GDTPDMKCDD MLTCYMFHMY VGVRAGGGIG DEIEDPAGDE YEIYRIIFDI TFFFFVIVIL
     LAIIQGLIID AFGELRDQQE QVKEDMETKC FICGIGNDYF DTVPHGFETH TLQEHNLANY
     LFFLMYLINK DETEHTGQES YVWKMYQERC WEFFPAGDCF RKQYEDQLN
//
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