ID G1P7D1_MYOLU Unreviewed; 403 AA.
AC G1P7D1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Potassium channel tetramerization domain containing 18 {ECO:0000313|Ensembl:ENSMLUP00000006025.2};
GN Name=KCTD18 {ECO:0000313|Ensembl:ENSMLUP00000006025.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000006025.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000006025.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000006025.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02003131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006082445.1; XM_006082383.2.
DR RefSeq; XP_014316697.1; XM_014461211.1.
DR RefSeq; XP_014316705.1; XM_014461219.1.
DR RefSeq; XP_014316712.1; XM_014461226.1.
DR AlphaFoldDB; G1P7D1; -.
DR STRING; 59463.ENSMLUP00000006025; -.
DR Ensembl; ENSMLUT00000006599.2; ENSMLUP00000006025.2; ENSMLUG00000006605.2.
DR GeneID; 102433926; -.
DR KEGG; mlf:102433926; -.
DR CTD; 130535; -.
DR eggNOG; KOG2723; Eukaryota.
DR GeneTree; ENSGT00530000064234; -.
DR HOGENOM; CLU_052824_0_0_1; -.
DR InParanoid; G1P7D1; -.
DR OMA; CKAGPKP; -.
DR OrthoDB; 2912088at2759; -.
DR TreeFam; TF315332; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18372; BTB_POZ_KCTD18; 1.
DR InterPro; IPR045704; KCTD18_C.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR14499:SF4; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD18; 1.
DR PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF19321; KCTD18_C; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 13..97
FT /note="Potassium channel tetramerisation-type BTB"
FT /evidence="ECO:0000259|Pfam:PF02214"
FT DOMAIN 113..401
FT /note="BTB/POZ"
FT /evidence="ECO:0000259|Pfam:PF19321"
FT REGION 317..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..383
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 44329 MW; A9472952370C9267 CRC64;
MEDHKEEEML DILRLNVGGC IYTARRESLC RFKDSMLASM FSGRFPLKTD ESGACVIDRD
GHLFKYLLDY LHGEVHIPTD EQTRVALQEE ADYFGIPYPY SLSDHLANEM ETYSLRSNIE
LKKALTDFCD SYGLVCNKPT VWVLHYLNTS GASCESRIIG VYATKTDGTD AIDKQLGGRI
HSKSIFKREA GNNVQYIWSY YSAAELKKMM DAFDAWEGKG VSYWRVPHEL IECWTLEERP
LLGSLRHMAP IRKRRLMALD EGEEGVNCKA GPKPVRFSGP STSTQIKVKN SASVRVSLSP
GGMPAQHSAP SKALSLVGTE VPGHSPSHGP GGPENGATSP PPAKVLLCDK KATPPRVIKL
KRTPLCATGP PPPTCPAASP AGALPPQAPT LDVRTENRQD KTD
//
