ID G1P7Q3_MYOLU Unreviewed; 724 AA.
AC G1P7Q3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Ankyrin repeat domain 6 {ECO:0000313|Ensembl:ENSMLUP00000006162.2};
GN Name=ANKRD6 {ECO:0000313|Ensembl:ENSMLUP00000006162.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000006162.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000006162.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000006162.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02024029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02024030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02024031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006091859.1; XM_006091797.2.
DR RefSeq; XP_006091860.1; XM_006091798.2.
DR RefSeq; XP_006091861.1; XM_006091799.2.
DR AlphaFoldDB; G1P7Q3; -.
DR STRING; 59463.ENSMLUP00000006162; -.
DR Ensembl; ENSMLUT00000006748.2; ENSMLUP00000006162.2; ENSMLUG00000006746.2.
DR GeneID; 102426083; -.
DR KEGG; mlf:102426083; -.
DR CTD; 22881; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000155887; -.
DR HOGENOM; CLU_027072_0_0_1; -.
DR InParanoid; G1P7Q3; -.
DR OMA; MKTEIHA; -.
DR TreeFam; TF332587; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:2000096; P:positive regulation of Wnt signaling pathway, planar cell polarity pathway; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24203; ANKYRIN REPEAT FAMILY PROTEIN; 1.
DR PANTHER; PTHR24203:SF45; DIEGO, ISOFORM A; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT REPEAT 41..73
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 74..106
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 107..139
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 140..172
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 173..205
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 206..238
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 277..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 692..719
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 277..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..379
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 79365 MW; 05FBE18782CEFF02 CRC64;
MSQQDAVAAL SERLLIAAYK GQAENVVQLI NKGAKVAVTK HGRTPLHLAA NKGHLAVVQI
LLKAGCDLDV QDDGDQTALH RAAVVGNTEV ISALTQEGCA LDRQDKDGNT ALHEASWHGF
SQSVKLLVKA GANVLAKNKA GNTALHLACQ NSHSQSTRVL LLGGSRADLK NNAGDTCLHV
AARYNHLSII KLLLSAFCSV HEKNQAGDTA LHVAASLNHK KVVKILLEAG ADVTIVNNAG
QTPLETARYH NNPEVALLLT KAPQVLRFSR GRSLRKKRER LKEERRAQSV PRDEVAQSKG
SVSAGDTPSS DQAAPRKEEA REDFLSASPE PRAKDNRRRK SRPKVSAFSD PTPPADQQPG
HQKNLHVHNH PKKRPKHRCS PPPPPHEFRA YQLYTLYRGK DGKVMQAPIN GCRCEPLINK
LENQLEATVE EIKAELGSVQ DKMNTKLGHM ESKTQHQMRV LDKLMVERLS AERTECLSRL
QQHSDTEKLE GEKRQMSLVD ELKTWCMLKI QNLELKLTGD SRAKSTPSTC ESSTAVDPSV
VTAGPVAASD SSPRVVRPKE KGLGSTAAHR LQQELSSSDC TGSRLRSVKV QTALLPLQEA
ARCDQQAGPC VHRGTQTKKS GKSGQTRHRA QPPAPSTTCG QPPPATGSEQ TASHIRDTSQ
ALEITQYFFE AVATQMEKWY ERKIEEARSQ ASQKAQQDKA TLKEHIKSLE EELAKLRTKV
QKEN
//
