ID G1P965_MYOLU Unreviewed; 695 AA.
AC G1P965;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=mRNA export factor GLE1 {ECO:0000256|ARBA:ARBA00026227};
DE AltName: Full=GLE1 RNA export mediator {ECO:0000256|ARBA:ARBA00030897};
DE AltName: Full=GLE1-like protein {ECO:0000256|ARBA:ARBA00031503};
DE AltName: Full=Nucleoporin GLE1 {ECO:0000256|ARBA:ARBA00029983};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000006750.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000006750.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000006750.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC from the nucleus into the cytoplasm. May be involved in the terminal
CC step of the mRNA transport through the nuclear pore complex (NPC).
CC {ECO:0000256|ARBA:ARBA00024680}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000256|ARBA:ARBA00004567}.
CC -!- SIMILARITY: Belongs to the GLE1 family.
CC {ECO:0000256|ARBA:ARBA00011056}.
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DR EMBL; AAPE02046833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006103203.1; XM_006103141.2.
DR AlphaFoldDB; G1P965; -.
DR STRING; 59463.ENSMLUP00000006750; -.
DR Ensembl; ENSMLUT00000007396.2; ENSMLUP00000006750.2; ENSMLUG00000007379.2.
DR GeneID; 102424352; -.
DR KEGG; mlf:102424352; -.
DR CTD; 2733; -.
DR eggNOG; KOG2412; Eukaryota.
DR GeneTree; ENSGT00390000012903; -.
DR HOGENOM; CLU_024662_1_0_1; -.
DR InParanoid; G1P965; -.
DR OMA; TFWKLLP; -.
DR OrthoDB; 317142at2759; -.
DR TreeFam; TF324158; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.510; GLE1-like; 1.
DR InterPro; IPR012476; GLE1.
DR InterPro; IPR038506; GLE1-like_sf.
DR PANTHER; PTHR12960; GLE-1-RELATED; 1.
DR PANTHER; PTHR12960:SF0; MRNA EXPORT FACTOR GLE1; 1.
DR Pfam; PF07817; GLE1; 1.
PE 3: Inferred from homology;
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nuclear pore complex {ECO:0000256|ARBA:ARBA00023132};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT REGION 62..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 79655 MW; 31B10139C0B40799 CRC64;
MPSESRCWET LQALRSSDKG RLCYHRDWLL RGEDVLEECV STPQLSSYAG WVVDHVLPHT
QENLSPSETS TSSRSTSGLD QPSFVPKSPI RSLAFSPASP GTPATPGGTK GKHESQHTEP
MLLQSSRGIK VEGCIRMYEL VHRMRGTEGL RLWQEEQERK VRALSEMASE QLKRFDERKE
LKHHKEFQDL REMMEKSSRE ALGQQEKLKA EHRHRAKIVN LKLWEAEQQR LKQVEQERLR
REEGQVRLRS LYALQEELLH LNQQLDSVGQ HRDLKVDLLA LRSRGNQLCG LISGIIRTTS
ENGFPTAEDQ AVAESALQEM RDLLTDARAC EDKRRQEEEE AQVKRQEAQM QQRPEVRKEC
PAPSQGPGGK RSEDLQVKVQ DSTMQWYQQL QEASRQCVLA FEGLTSSKDS QVKKIKMDLQ
KAATIPVSQI STIAGSKLKE IFDKIHNLLS GKPVQSGGRS VSVTLNPQGL DFVQYKLAEK
FVKQGEEEVA SHHEAAFPIA VVASGIWELH PRVGDLILAH LHKNCPYSVP FYPAFREGMA
LEDYQRMLGY QVKDSKVEQQ DNFLKRMSGM MRLYAAIIQL RWPYGTRQEV HPHGLNHGWR
WLAQILNMEP LSDVTATLLF DFLEVCGNAL MKQYQAQFWK MMLLIKEDYF PRIEAITSSG
QMGSFIRLKQ FLEKCLQRKE IPVPKGFLTS SFWRS
//