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Database: UniProt
Entry: G1PCN8_MYOLU
LinkDB: G1PCN8_MYOLU
Original site: G1PCN8_MYOLU 
ID   G1PCN8_MYOLU            Unreviewed;       882 AA.
AC   G1PCN8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   20-DEC-2017, entry version 37.
DE   SubName: Full=N-deacetylase and N-sulfotransferase 1 {ECO:0000313|Ensembl:ENSMLUP00000008188};
GN   Name=NDST1 {ECO:0000313|Ensembl:ENSMLUP00000008188};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000008188, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000008188, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000008188}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000008188}.
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DR   EMBL; AAPE02018688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02018689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006089202.1; XM_006089140.2.
DR   RefSeq; XP_006089203.1; XM_006089141.2.
DR   RefSeq; XP_006089204.1; XM_006089142.2.
DR   RefSeq; XP_014311689.1; XM_014456203.1.
DR   RefSeq; XP_014311690.1; XM_014456204.1.
DR   STRING; 59463.ENSMLUP00000008188; -.
DR   Ensembl; ENSMLUT00000008985; ENSMLUP00000008188; ENSMLUG00000008968.
DR   GeneID; 102431146; -.
DR   CTD; 3340; -.
DR   eggNOG; KOG3703; Eukaryota.
DR   eggNOG; ENOG410XQN4; LUCA.
DR   GeneTree; ENSGT00760000119023; -.
DR   InParanoid; G1PCN8; -.
DR   OMA; TNTIDYH; -.
DR   OrthoDB; EOG091G02CP; -.
DR   TreeFam; TF313193; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:Ensembl.
DR   GO; GO:0019213; F:deacetylase activity; IEA:Ensembl.
DR   GO; GO:0042328; F:heparan sulfate N-acetylglucosaminyltransferase activity; IEA:Ensembl.
DR   GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR   GO; GO:0003279; P:cardiac septum development; IEA:Ensembl.
DR   GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR   GO; GO:0048702; P:embryonic neurocranium morphogenesis; IEA:Ensembl.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR   GO; GO:0030203; P:glycosaminoglycan metabolic process; IEA:Ensembl.
DR   GO; GO:0015014; P:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; IEA:Ensembl.
DR   GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0006477; P:protein sulfation; IEA:Ensembl.
DR   GO; GO:0007585; P:respiratory gaseous exchange; IEA:Ensembl.
DR   InterPro; IPR021930; Heparan_SO4_deacetylase.
DR   InterPro; IPR037359; NST/OST.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR10605; PTHR10605; 1.
DR   Pfam; PF12062; HSNSD; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     20     39       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       26    515       HSNSD. {ECO:0000259|Pfam:PF12062}.
FT   DOMAIN      605    858       Sulfotransfer_1. {ECO:0000259|Pfam:
FT                                PF00685}.
SQ   SEQUENCE   882 AA;  101003 MW;  081B863405612659 CRC64;
     MPTLARLRRL CRHVSPQAIF FLLFVFCVFS VCVSAYYLYG WKRGLEPSAD APEPDCGDPP
     PVAPSRLLPL KPVQAATPSR TDPLVLVFVE SLYSQLGQEV VAILESSRFK YRTEIAPGKG
     DMPTLTDKGR GRFALIIYEN ILKYVNLDAW NRELLDKYCV AYGVGIIGFF KANENSLLSA
     QLKGFPLFLH SNLGLKDCSI NPRSPLLYVT RPSEVEKGML PGEDWTVFQS NHSTYEPVLL
     AKTRSSESMP HLGADAGLHA ALHTTVVQDL GLHDGIQRVL FGNNLNFWLH KLIFVDAVAF
     LTGKRLSLPL DRYILVDIDD IFVGKEGTRM KVEDVKALFD TQNELRTHIP NFTFNLGYSG
     KFFHTGTDAE DAGDDLLLSY VKEFWWFPHM WSHMQPHLFH NQSVLAEQMA LNKKFAVEHG
     IPTDMGYAVA PHHSGVYPVH VQLYEAWKQV WNIRVTSTEE YPHLKPARYR RGFVHNGIMV
     LPRQTCGLFT HTIFYSEYPG GSSELDKIIN GGELFLTVLL NPISIFMTHL SNYGNDRLGL
     YTFKHLVRFL HSWTNLRLQT LPPVQLAQKY FQIFSEEKDP LWQDPCEDKR HKDIWSKEKT
     CDRFPKLLII GPQKTGTTAL YLFLGMHPDL SSNYPSSETF EEIQFFNGQN YHKGIDWYME
     FFPIPSNTTS DFYFEKSANY FDSEVAPRRA AALLPKAKVL TILINPADRA YSWYQHQRAH
     DDPVALKYTF HEVITAGPDA SLKLRALQNR CLVPGWYATH IERWLSAFHA NQILVLDGKL
     LRTEPAKVMD TVQKFLGVTN TIDYHKALAF DPKKGFWCQL LEGGKTKCLG KSKGRKYPEM
     DLDSRAFLKD YYRDHNIELS KLLYKMGQTL PTWLREDLQN TR
//
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