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Database: UniProt
Entry: G1PEQ5_MYOLU
LinkDB: G1PEQ5_MYOLU
Original site: G1PEQ5_MYOLU 
ID   G1PEQ5_MYOLU            Unreviewed;      1977 AA.
AC   G1PEQ5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   30-AUG-2017, entry version 44.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN8A {ECO:0000313|Ensembl:ENSMLUP00000009007};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000009007, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000009007, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000009007}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000009007}.
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DR   EMBL; AAPE02030866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02030867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02030868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000009007; -.
DR   Ensembl; ENSMLUT00000009880; ENSMLUP00000009007; ENSMLUG00000009841.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G1PEQ5; -.
DR   OMA; YMIDEDH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    199    219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    387    414       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    751    769       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    781    799       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    861    889       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    948    974       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1196   1214       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1235   1254       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1266   1289       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1310   1338       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1435   1461       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1520   1538       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1550   1568       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1580   1600       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1637   1665       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1740   1763       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      131    421       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      499    698       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      751    978       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      988   1189       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1194   1469       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1519   1773       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      411    449       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1977 AA;  224766 MW;  6B1772FBE4346A7A CRC64;
     MAGRLLAPPG PDSFKPFTPE SLANIERRIA ESKLKKPPKG DGSHRDDDED SKPKPNSDLE
     AGKSLPFIYG DIPQGLVAVP LEDFDPYYLT QKTFVVLNRG KTLFRFSATP ALYILSPFNL
     IRRIAIKILI HSLFSMIIMC TILTNCVFMT FSNPPDWSKN VEYTFTGIYT FESLVKIIAR
     GFCIDGFTFL RDPWNWLDFS VIMMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI
     VGALIQSVKK LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVVWPINFND SYLENGTRGF
     DWDEYINNKT NFYTVPGMLE PLLCGNSSDA GQCPEGYQCM KAGRNPNYGY TSFDTFSWAF
     LALFRLMTQD YWENLYQLTL RAAGKTYMIF FVLVIFVGSF YLVNLILAVV AMAYEEQNQA
     TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA MATSAGTVSE DAIEEEGEEE GGSPRSSSEM
     SKLSSKSAKE RRNRRRKRKQ KELSEGEEKG DPEKVFKSES EDGMRRKGFR LPDNRIGRKF
     SIMNQSLVSI PGSPLSGHNS KSSIQLRGPG RFRDPGSENE FADDEHSPVE ESEGRRDSLF
     IPIRRERRSS YSGYSGYSQG SRSSRIFPSL RRSVKRNSTV DCNGVVSLIG GPGSHIGGRL
     LPEGTTEVEI KKKGPGSLLV SMEQLASYGR KDRINSILSV VTNTLVEELE ESQRKCPPCW
     YKFANTFLIW ECHPYWIKLK EIVNLIVMDP FVDLAITICI VLNTLFMAME HHPMTPQFEH
     VLSVGNLVFT GIFTAEMFLK LIAMDPYYYF QEGWNIFDGF IVSLSLMELS LADVEGLSVL
     RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG MQLFGKSYKE
     CVCKINQDCE LPRWHMHDFF HSFLIVFRVL CGEWIETMWD CMEVAGQAMC LIVFMMVMVI
     GNLVVLNLFL ALLLSSFSAD NLAATDDDGE MNNLQISVIR IKKGVAWTKV KVHAFMQAHF
     KQREADEVKP LDEMYDKKAN CIANHTGADI HRNGDFQKNG NGTTSGIGSS VEKYIIDEDH
     MSFINNPNLT VRVPIAVGES DFENVNTEDV SSESDPDGSK DKLDDTSSSE GSTIDIKPEV
     EEVPVEQPEE YLDPEACFTE GCVRRFKCCT VNIEEGLGKS WWILRKTCFL IVEHNWFETF
     IIFMILLSSG ALAFEDIYIE QRRTIRTVLE YADKVFTYIF ILEMLLKWTA YGFVKFFTNA
     WCWLDFLIVA VSLVSLVANA LGYSELGAIK SLRTLRALRP LRALSRFEGM RVVVNALVGA
     IPSIMNVLLV CLIFWLIFSI MGVNLFAGKY HYCFNETSEE RFEIEIVNNK TDCEKLMEGN
     NTEIRWKNVK INFDNVGAGY LALLQVATFK GWMDIMYAAV DSRKPEEQPK YEDNIYMYIY
     FVIFIIFGSF FTLNLFIGVI IDNFNQQKKK FGGQDIFMTE EQKKYYNAMK KLGSKKPQKP
     IPRPLNKIQG IVFDFVTQQA FDIVIMMLIC LNMVTMMVET DTQSKQMETI LYWINLVFVI
     FFTCECVLKM FALRHYYFTI GWNIFDFVVV ILSIVGMFLA DIIEKYFVSP TLFRVIRLAR
     IGRILRLIKG AKGIRTLLFA LMMSLPALFN IGLLLFLVMF IFSIFGMSNF AYVKHEAGID
     DMFNFETFGN SMICLFQITT SAGWDGLLLP ILNRPPDCSL DKEHPGSGFK GDCGNPSVGI
     FFFVSYIIIS FLIVVNMYIA IILENFSVAT EESADPLSED DFETFYEIWE KFDPDATQFI
     EYCKLADFAD ALEHPLRVPK PNTIELIAMD LPMVSGDRIH CLDILFAFTK RVLGDSGELD
     ILRQQMEERF VASNPSKVSY EPITTTLRRK QEEVSAVVLQ RAYRGHLARR GFICKKIASN
     KLENGGTHPE KKESTPSTAS LPSYDSVTKP EKEKQQRAEE GRRERAKRQK EVRESKC
//
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