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Database: UniProt
Entry: G1PFA2_MYOLU
LinkDB: G1PFA2_MYOLU
Original site: G1PFA2_MYOLU 
ID   G1PFA2_MYOLU            Unreviewed;      4938 AA.
AC   G1PFA2;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   30-AUG-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSMLUP00000009236};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSMLUP00000009236};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000009236, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000009236, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000009236}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000009236}.
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DR   EMBL; AAPE02032928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02032929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02032930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02032931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02032932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02032933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02032934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000009236; -.
DR   Ensembl; ENSMLUT00000010134; ENSMLUP00000009236; ENSMLUG00000009950.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1PFA2; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   PANTHER; PTHR13715:SF97; PTHR13715:SF97; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4473   4493       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4738   4760       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4819   4842       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    219       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      225    279       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      285    342       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      350    407       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      596    812       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1028   1223       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1354   1568       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1860   1913       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4938 AA;  558027 MW;  25C405EBE58E7F1B CRC64;
     MGDGGEGEDE VQFLRTDDEV VLQCSATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP
     DLAICCFVLE QSLSVRALQE MLANTVEAGV EVRLPLSRWV ARMRQSSQGG GHRTLLYGHA
     ILLRHAHSSM YLSCLTTSRS MTDKLAFDVG LQEDATGEAC WWTMHPASKQ RSEGEKVRVG
     DDLILVSVSS ERYLHLSTAS GELQVDASFM QTLWNMNPIS SGCEEGCVTG GHVLRLFHGH
     MDECLTISPA DSDDQRRLVH YEGGAVCTHA RSLWRLEPLR ISWSGSHLRW GQPLRIRHVT
     TGRYLALTED QGLVVVDASK AHTKATSFCF RISKEKLDVA PKRDVEGMGP PEIKYGESLC
     FVQHVASGLW LTYAAPDPKA LRLGVLKKKA MLHQEGHMDD ALSLTRCQQE ESQAARMIYS
     TAGLYNQFIK GLDSFSGKPR GSGPPAGTAL PIEGVVLSLQ DLIGYFEPPS EELQHEEKQS
     KLRSLRNRQS LFQEEGMLSL VLNCIDRLNV YTTAAHFAEF AGEEAAESWK EIVNLLYELL
     ASLIRGNRTN CALFSNNLDW LVSKLDRLEA SSGILEVLYC VLIESPEVLN IIQENHIKSI
     ISLLDKHGRN HKVLDVLCSL CVCNGVAVRS NQDLITENLL PGRELLLQTN LINYVTSIRP
     NIFVGRAEGS TQYGKWYFEV MVDEVTPFLT AQATHLRVGW ALTEGYSPYP GGGEGWGGNG
     VGDDLYSYGF DGLHLWTGHV ARPVTSPGQH LLAPEDVVSC CLDLSVPSIS FRINGCPVQG
     VFEAFNLDGL FFPVVSFSAG VKVRFLLGGR HGEFKFLPPP GYAPCHEAVL PRERLHLEPI
     KEYRREGPRG PHLVGPSRCL SHTDFVPCPV DTVQIVLPPH LERIREKLAE NIHELWALTR
     IEQGWTYGPV RDDNKRLHPC LVNFHSLPEP ERNYNLQMSG ETLKTLLALG CHVGMADEKA
     EDNLKKTKLP KTYMMSNGYK PAPLDLSHVR LTPAQTTLVD RLAENGHNVW ARDRVAQGWS
     YSAVQDIPAR RNPRLVPYRL LDEATKRSNR DSLCQAVRTL LGYGYNIEPP DQEPSLVESQ
     SRWDRVRIFR AEKSYAVQSG RWYFEFEAVT TGEMRVGWAR PELRPDVELG ADELAYVFNG
     HRGQRWHLGS EPFGRHWQSG DVVGCMIDLT ENTIIFTLNG EILMSDSGSE TAFRDIEIGD
     GFLPVCSLGP GQVGHLNLGQ DVSSLRFFAI CGLQEGFEPF AINMQRPVTT WFSKSLPQFE
     AVPLEHPHYE VARVDGTVDT PPCLRLTHRT WGSQNSLVEM LFLRLSLPVQ FHQHFRCTAG
     ATPLASPGLQ PPAEDEAWAA EPDTDYENLR RSAGRWGEAE GGKEAGAEAQ PARAENEKDA
     TTEKNKKRGA KKAAMMTQPP ATPALPRLPR EVVPADNRDD PEIILNTTTY YYSVRVFAGQ
     EPSCVWVGWV TPDYHQHDMN FDLTKVRAVT VTMGDEQGNV HSSLKCSNCY MVWGGDFVSS
     GQQGRISHTD LVIGCLVDLA TGLMTFTANG KESNTFFQVE PNTKLFPAVF VLPTHQNVIQ
     FELGKQKTSC PLSAAMFLSE RKNPPQCPPR LEVQMLMPIS WSRMPNHFLQ VDTRRAGERL
     GWAVECQEPL IMMALHIPEE NRCMDILELS ERLNLQRFHS HTLRLYRAVC ALGNNRVAHA
     LCSHVDQAQL LHALEDAHLP GPLRAGYYDL LISIHLESAC RSRRSMLSEY IVPLTPETRT
     ITLFPPGKST DNGPRRHGFP GGITTSLRPP HHFSPPCFVG WRKVPARLSP SIPLEALRDK
     ALRMLGEAVR DGGQHARDPV GGSVEFQFVP VLKLVSTLLV MGVFGDEDVK QILKMIEPEV
     FTEEQEEEEE EEEEEEDEEE KEEDEEEESQ EKEDEEKEEE ETAEEEKEGL EEGLLQMKLP
     ESVKLQFSNL HSSGVGDTVV RLEKQEKFQR VLYYVTVGWL NVFGWMCIWM DGYWQRDESG
     EMADWKDGKS SKPPPGIQLE GKEEEPEEEV TLGSRLMSLL EKVRLVKKKE EKPEEELPAE
     ESKPRFILLR HNVRWPWVLR RIKLSERRER DKHGGVIMSL PLTVPPTPGI TLGDGSPKSL
     RALPGLGPHA RTTFVHRNIM NNKVFYQHPN LMRALGMHET VMEVMVNVLG GGESKEIRFP
     KMVTSCCRFL CYFCRISRQN QRSMFDHLSY LLENSGIGLG MQGSTPLDVA AASVIDNNEL
     ALALQEQDLE KVVSYLAGCG LQSCPMLLAK GYPDIGWNPC GGERYLDFLR FAVFVNGESV
     EENANVVVRL LIRKPECFGP ALRGEGGSGL LAAIEEAIRI SEDPARDGPG VRRDRRREHF
     GEEPPEENRV HLGHAIMSFY AALIDLLGRC APEMHLIQAG KGEALRIRAI LRSLVPLDDL
     VGIISLPLQI PTLGKDGALV QPKMSASFVP DHKASMVLFL DRVYGIENQD FLLHVLDVGF
     LPDMRAAASL DTATFSTTEM ALALNRYLCL AVLPLITKCA PLFAGTEHRA IMVDSMLHTV
     YRLSRGRSLT KAQRDVIEDC LMALCKYIRP SMLQHLLRRL VFDVPILNEF AKMPLKLLTN
     HYERCWKYYC LPTGWANFGI TSEEELHLTR KLFWGIFDSL AHKKYDPELY RIAMPCLCAI
     AGALPPDYVD ASYSSKAEKK ATVDAEGNFD PRPVETLNVI IPEKLDSFIN KFAEYTHEKW
     AFDKIQNNWS YGENVDEELK THPMLRPYKT FSEKDKEIYR WPIKESLKAM IAWEWTIEKA
     REGEEEKTEK KKTRKISQSA QVTYDPREGY NPQPPDLSGV TLSRELQAMA EQLAENYHNT
     WGRKKKQELE AKGGGTHPLL VPYDTLTAKE KARDREKAQE LLKFLQMNGY AVTRGLKDME
     LDTSSIEKRF AFGFLQQLLR WMDISQEFIA HLEAVVSSGR VEKSPHEQEI KFFAKILLPL
     INQYFTNHCL YFLSTPAKVL GSGGHASNKE KEMITSLFCK LAALVRHRVS LFGTDAPAVV
     NCLHILARSL DARTVMKSGP EIVKAGLRSF FESASEDIEK MVENLRLGKV SQARTQVKGV
     GQNLTYTTVA LLPVLTTLFQ HIAQHQFGDD VILDDVQVSC YRTLCSIYSL GTTRNSYVEK
     LRPALGECLA RLAAAMPVAF LEPQLNEYNA YSVYTTKSPR ERAILGLPNS VEEMCPDIPV
     LERLMADIGG LAESGARYTE MPHVIEITLP MLCSYLPRWW ERGPEVPPPT LPAGVLPPCT
     AVTSDHLNSL LGNILRIIVN NLGIDEASWM KRLAVFAQPI VSRARPELLH SHFIPTIGRL
     RKRAGKVVAE EEQLRLEAKA EAEEGELLVR DEFSVLCRDL YALYPLLIRY VDNNRAHWLT
     EPNPNAEELF RMVGEIFIYW CKSHNFKREE QNFVVQNEIN NMSFLTADNK SKMAKSGGSD
     QERTKKKRRG DRYSVQTSLI VATLKKMLPI GLNMCAPTDQ DLIALAKTRY ALKDTDEEVR
     EFLHNNLHLQ GKVEGSPSLR WQMALYRGLP GREEDADDPE KIVRRVQEVS AVLYHLEQVG
     GQQGLTGRCK VEHPFKSKKA VWHKLLSKQR RRAVVACFRM TPLYNLPTHR ASNMFLERYK
     ATWILTEDHS FEDRMIDDLS KAGEQEEEEE EVEEKKPDPL HQLVLHFSRT ALTEKSKLDE
     DYLYMAYADI MAKSCHLEEG GENGEGEEEV EVSFEEKEME KQRLLYQQAR LHNRGAAEMV
     LQMISACKGE TGAMVSSTLK LGISILNGGN ADVQQKMLDY LKDKKEVGFF QSIQALMQTC
     SVLDLNAFER QNKAEGLGMV NEDGTGEKVM ADDEFTQDLF RFLQLLCEGH NNDFQNYLRT
     QTGNTTTINI IICTVDYLLR LQESISDFYW YYSGKDVIEE QGKRNFSKAM SVAKQVFNSL
     TEYIQGPCTG NQQSLAHSRL WDAVVGFLHV FAHMMMKLAQ DSSQIELLKE LLDLQKDMVV
     MLLSLLEGNV VNGMIARQMV DMLVESSSNV EMILKFFDMF LKLKDIVGSE AFQDYVTDPR
     GLISKKDFQK AMDSQKQFSS PEIQFLLSCS EADENEMINC EEFANRFQEP AREIGFNVAV
     LLIDLSEHVP HDPRLRNFLE LADSILEYFR PYLGRIEIMG ASRRIERIYF EISETNRTQW
     EMPQVRGPAC WLPGLGVTLL APLDSTQGFY GSCSALVHPQ FPLVHLLQPW RTHRCTPLVP
     AHNAHPSYSG PTCSVFLQTC TCTCSPFPLH FPLLAWAWSI PQQCHSEHRG MAKEAEIIDS
     EASLLRTYSE HYMRLLLTVL FLGRDKERYL ESQRARGPEM KLEGKQDQKL KTAEMGSGTP
     EKTLRDTDGC GDPQVLGAMS APGEWERWGE AGALQSRVRG LRPKRPASTI ASLLTEPDPG
     GNDQEGPQSQ VDGEEEELPP EPEPEPEPEP EKADAENGEK EEVPEPPPDP PKKTAPPPPH
     SKKEDTKGGG LEFWGELEVQ RVKFLNYLSR NFYTLRFLAL FLAFAINFIL LFYKVLVMRG
     QEDLGCGVGG SAPNKFTGSL QFTSDKVLVV YYFLEESTGY MEPALRCLSL LHTLVAFLCI
     IGYNCLKVPL VIFKREKELA RKLEFDGLYI TEQPEDDDVK GQWDRLVLNT PSFPSNYWDK
     FVKRKVLDKH GDIYGRERIA ELLGMDLASL EISVHHERKP EPPPGLLTWL MSIDIKYQIW
     KFGVIFTDNS FLYLGWYMVM SLLGHYNNFF FAAHLLDMAM GVRHCAILSC VTHNGKQLVM
     TVGLLAVVVY LYTVVAFNFF RKFYNKSEDE DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD
     EIEDPAGDEY ELYRVVFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VKEDMETKCF
     ICGIGSDYFD TTPHGFETHT LEEHNLANYM FFLMYLINKD ETEHTGQESY VWKMYQERCW
     DFFPAGDCFR KQYEDQLN
//
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