ID G1PFL9_MYOLU Unreviewed; 1407 AA.
AC G1PFL9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Uveal autoantigen with coiled-coil domains and ankyrin repeats {ECO:0000313|Ensembl:ENSMLUP00000009385.2};
GN Name=UACA {ECO:0000313|Ensembl:ENSMLUP00000009385.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000009385.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000009385.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000009385.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02015730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000009385; -.
DR Ensembl; ENSMLUT00000010300.2; ENSMLUP00000009385.2; ENSMLUG00000010284.2.
DR eggNOG; ENOG502QPYN; Eukaryota.
DR GeneTree; ENSGT00940000157475; -.
DR HOGENOM; CLU_005323_1_0_1; -.
DR InParanoid; G1PFL9; -.
DR OMA; KCHEMEK; -.
DR TreeFam; TF331274; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24129; ANKYCORBIN; 1.
DR PANTHER; PTHR24129:SF2; UVEAL AUTOANTIGEN WITH COILED-COIL DOMAINS AND ANKYRIN REPEATS; 1.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 57..89
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 90..122
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 123..155
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 156..188
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 189..221
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT COILED 279..362
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 443..502
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 529..667
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 695..729
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 765..830
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 866..1257
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1290..1367
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1407 AA; 162093 MW; BD055A6F48485975 CRC64;
VLSMMNCWFS CAPKNKHAAD WNKYDDRLMK AAERGDVEKV SSILAKKGVN PGKLDVEGRS
VFHVVASKGN LECLNAILVN GVDITTTDTA GRNALHLAAK YGHALCLQKL LQYNCPTEHA
DLQGRTALHD AAMADCPSSI QLLCDHGASV NAKDVDGRTP LVLATQMCRP TICQLLIDRG
ADINSSDKQN RTALMLGCEY GCKDAVEVLI KNGADVSLLD ALGHDSSYYA RIGDNLDILT
LLKTASENTN KGRELWKKGP SIQQRNMTHM LDEVNMKSNQ REHQSIQDLQ IENGDLKERL
RKIQQEQRIL LDKVNGLQLQ LNEEVMVADD LESEKEKLKS LLVAKEKQHE ESLRAIEALK
NRYKYFESDH VGSGSHFSNR KEDMLLKQGQ MYMTDSQCTS TGVPAHMQSR SMLRPLELSL
PNQTSYSENE ILKKELETMR TFCESAKQDR LKLQNELAHK VAECKALALE CERVKEDSDE
QIKQLEDALK DVQKRMYESE GKVKQMQTHF LALKEHLTSE AASGNHRLME ELKDQLKDMK
AKYEGASAEV GKLRNQIKQN EMLVEEFKRD EGKLVEENKR LQKEFSMCEM EREKKGRRVT
EMEGQLKELL AKLALSIPKE KFENMKSLLS NEVNEKAKKL VDMEREYEKS LSEIKQLKRE
LENFKAKISQ HVKPEEHEQL KSRLEQKSGE LGKKVTELIS KNQTLQKEIE KANLDNKLLN
QQVHNLTTEM KNHYIPLKVS EEMKKSHDVI IGDLNKKLLD VTEKYTEKKL EMEKLLMEND
NLNKNVNRLE TVFIPPEKHE KEMMMLKSNI VELKKQLSEL NKKCGEDQEK VYSLMSENTN
LKKTMSNQYV PVKTHEEIKT ALSSTLDKTN RELLDVKKKF EHVNKELVKI KDENEILRRN
LENTQNQMKA EYISLREHEE KVSAVSKSMR NVQENSAEIL ANYKKGQEEI VTLHAEIEAQ
KKELDTIQEC IKVKYAPIAS FEECEKKFKT IEKELKEQLS EQTQKYNVRD EETKKCKQEN
DKLKEEIFTL QKDLRDKNVL IENSHEMERA LNRKTEELNR QLKDLLQKYT EVKNEKEKLV
EENAKQTSDI LTAQTLLQKQ YVPSEQVEAL EKSLNGTIET LREELKNKQR CYEEEQQTVT
KLHQLLENQK NSSVSLAKHL QMKEAFEKEV GIIKATLRAK EEENRNKTEE ISKLQLEVQN
SKQALKKLET REVVDMSKYK ATKSDLETQI SNLNEKLANL NKKYEEVCEE VLHAKKKGLS
AKGDKELLHF SIEQEIKDQQ ERCDKSLSTI TELQTRIQES AKQIEAKDNK KITELLNDVE
RLKQALNGLS QLTYTSGSPS KRQSQLIDTL QHQVRSLQQQ LTDAHRQHQE VIAIYRTHLL
SAAQGHMDED VQAALLQIIQ MRQGLVC
//