ID G1PG62_MYOLU Unreviewed; 463 AA.
AC G1PG62;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Regulator of G protein signaling 11 {ECO:0000313|Ensembl:ENSMLUP00000009607.2};
GN Name=RGS11 {ECO:0000313|Ensembl:ENSMLUP00000009607.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000009607.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000009607.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000009607.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02047867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02047868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PG62; -.
DR STRING; 59463.ENSMLUP00000009607; -.
DR Ensembl; ENSMLUT00000010540.2; ENSMLUP00000009607.2; ENSMLUG00000010526.2.
DR eggNOG; KOG3589; Eukaryota.
DR GeneTree; ENSGT00940000160198; -.
DR HOGENOM; CLU_025092_0_0_1; -.
DR InParanoid; G1PG62; -.
DR OMA; EFYKQEM; -.
DR TreeFam; TF351956; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0031681; F:G-protein beta-subunit binding; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08740; RGS_RGS11; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF3; REGULATOR OF G-PROTEIN SIGNALING 11; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 296..411
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 438..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 52388 MW; CFDD3DA4D4520456 CRC64;
MAAGPASHGG CPRAQMPHLS KVGAGWGSCR PQDFWHQGRE GQRPCSILPD EDVPPALTSQ
PHPEALHLGV LLVLHGYLYA LREPRSPGLQ LDETLYRFQT PYFWTSTLWP AAELDYAIYL
AKKNIRKQGA LVDHEKEHYD QLHRKINHTW DLVVMQAREQ LRASKQRRKA DRLVIACQEQ
TYWLVNRPPP GVPSVLEQGP ERGSCMARRV QVTKNTDFYK QEIECCTKAL GRIRVKSSVC
LEAYLKFSSQ HGPHDPIMSG CLPSNPWITD DDTYWAMNAP NVAVPTKLRV ERWGFSFREL
LEDPVGRAHF MDFLRKEFSA ENLSFWEACE ELRHGGQAQI PALVDSVYQQ FLAPGAARWV
NIDSQTMERT LEGLRQPHRY VLDDAQLHIY MLMKKDSYPR FLKSDMYKGL LAEATILPET
KRRVFPFMWK PRHSSLSPAL PPASASVEPA AAAGGPGGGD GEA
//
