ID G1PH34_MYOLU Unreviewed; 307 AA.
AC G1PH34;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Leukocyte surface antigen CD47 {ECO:0000256|ARBA:ARBA00015454};
DE AltName: Full=Integrin-associated protein {ECO:0000256|ARBA:ARBA00033289};
GN Name=CD47 {ECO:0000313|Ensembl:ENSMLUP00000009971.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000009971.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000009971.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000009971.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAPE02020355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PH34; -.
DR STRING; 59463.ENSMLUP00000009971; -.
DR Ensembl; ENSMLUT00000010939.2; ENSMLUP00000009971.2; ENSMLUG00000010929.2.
DR eggNOG; ENOG502RYTQ; Eukaryota.
DR GeneTree; ENSGT00390000007697; -.
DR HOGENOM; CLU_860392_0_0_1; -.
DR InParanoid; G1PH34; -.
DR OMA; CISECTP; -.
DR TreeFam; TF336026; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098632; F:cell-cell adhesion mediator activity; IEA:Ensembl.
DR GO; GO:0070053; F:thrombospondin receptor activity; IEA:Ensembl.
DR GO; GO:1904669; P:ATP export; IEA:Ensembl.
DR GO; GO:0071349; P:cellular response to interleukin-12; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro.
DR GO; GO:0050766; P:positive regulation of phagocytosis; IEA:InterPro.
DR GO; GO:0050870; P:positive regulation of T cell activation; IEA:Ensembl.
DR GO; GO:0032653; P:regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0032655; P:regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0032675; P:regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032680; P:regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0032649; P:regulation of type II interferon production; IEA:Ensembl.
DR CDD; cd16090; IgV_CD47; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR006704; CD47.
DR InterPro; IPR013147; CD47-like_TM.
DR InterPro; IPR013270; CD47_Vset.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR037805; IgV_CD47.
DR PANTHER; PTHR10613; LEUKOCYTE SURFACE ANTIGEN CD47; 1.
DR PANTHER; PTHR10613:SF0; LEUKOCYTE SURFACE ANTIGEN CD47; 1.
DR Pfam; PF04549; CD47; 1.
DR Pfam; PF08204; V-set_CD47; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Pyrrolidone carboxylic acid {ECO:0000256|ARBA:ARBA00023283};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..307
FT /note="Leukocyte surface antigen CD47"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003418518"
FT TRANSMEM 143..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..127
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 307 AA; 33798 MW; E7E20C91EA34E65A CRC64;
LWCFFVLFCF LVSMKCGSSA QLIFNITKFA EYTICNKTVV IPCLVNNVGA QSLKEMFVKW
KFRDKYIFFY DGDKNESSPN SNFSSAFIVP EALLSGIASL KMDKSDAVPG NYTCEVTELT
REGETIVELK YRVVSWFSPN ENILIVIFPM LAVLLFWGQF GIVTLKYNAS VTKEKTILLF
VAGLVLTTFV IVGAILFVPG EYSTKRASGL GLIVVPTVIL ILLQYSVFMI APAIGMSSFS
ITILILQVLG FVLSVVGLSL CVSECTPMHG PLLISGLGII ALAELLGLVY MKFVASNQRA
IQPPRNN
//
