ID G1PI66_MYOLU Unreviewed; 2404 AA.
AC G1PI66;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Teneurin transmembrane protein 4 {ECO:0000313|Ensembl:ENSMLUP00000010388.2};
GN Name=TENM4 {ECO:0000313|Ensembl:ENSMLUP00000010388.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010388.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010388.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010388.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AAPE02022808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000010388; -.
DR Ensembl; ENSMLUT00000011400.2; ENSMLUP00000010388.2; ENSMLUG00000011352.2.
DR eggNOG; KOG4659; Eukaryota.
DR GeneTree; ENSGT01030000234566; -.
DR HOGENOM; CLU_000229_0_0_1; -.
DR InParanoid; G1PI66; -.
DR OMA; HWTQSAP; -.
DR TreeFam; TF316833; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0032289; P:central nervous system myelin formation; IEA:Ensembl.
DR GO; GO:0048666; P:neuron development; IEA:Ensembl.
DR GO; GO:0031641; P:regulation of myelination; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF9; TENEURIN-4; 1.
DR Pfam; PF05593; RHS_repeat; 2.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 257..289
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 387..418
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 427..462
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 279..288
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 391..401
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 408..417
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 431..441
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 452..461
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2404 AA; 268247 MW; 5B81D3655E4BE698 CRC64;
AMHLFGLNWH LQPMEGQMYE ITEDTASSWP VPTDVSLYPS GGTGLEIPDR KGKGATEEDS
FIDSGEIDVG RRASQKIPPG TFWRSQVFID HPVYLKFNVS LGKAALVGIY GRKGLPPSHT
QFDFVELLDG RRLLTQEARS LEGPQRQSRG AVPPSSHETG FIQYLDSGIW HLAFYNDGKE
SEVVSFLTTA IESVDNCPSN CYGNGDCISG TCHCFLGFLG PDCGRASCPV LCSGNGQYMK
GRCLCHSGWK GAECDVPTNQ CIDVACSNHG TCIMGTCICN PGYKGENCEE VDCMDPTCSG
RGVCVRGECH CSVGWGGTNC ESPRATCLDQ CSGHGTFLPD TGLCSCDPSW TGHDCSIEIC
AADCGGHGVC VGGTCRCEEG WMGAACDQRA CHPRCAEHGT CRDGKCECSP GWNGEHCTIA
HYLDRVVKEG CPGLCNGNGR CTLDLNGWHC VCQLGWRGAG CDTSMETACG DSKDNDGDGL
VDCMDPDCCL QPFCHVNPLC LGSPDPLDII HPAWSPQLPP PVSQQNLHSF YDRIKFLVGR
DSTHIIPGEN PFDGGHACVI RGQVMTSDGT PLVGVNISFV NNPLFGYTIS RQDGSFDLVT
NGGISIILRF ERAPFITQEH TLWLPWDRFF VMETIIMRHE ENEIPSCDLS NFARPNPIVS
PSPLTSFASS CAEKGPIVPE IQALQEEIAI SGGKMRLSYL SSRTPGYKSV LRVSLTHPTI
PFNLMKVHLM VAVEGRLFRK WFAAAPDLSY YFIWDKTDVY NQKVFGLSEA FVSVGYEYES
CPDLILWEKR TAVLQGYEID ASRLGGWSLD KHHALNIQSG ILHKGNGENQ FVSQQPPVIG
SIMGNGRRRS ISCPSCNGLA DGNKLLPVAL TCGSDGSLYV GDFNYIRRIF PSGNVTNILE
LRNKDFRHSH SPAHKYYLTT DPMSGAVFLS DTNSRRVFKI KSTTVVKDLV KNSEVVAGTG
DQCLPFDDTR CGDGGKATEA TLTNPRGITV DKSGLIYFVD GTMIRRIDQN GVISTLLGSN
DLTSARPLSC DSVMDISQVR LEWPTDLAIN PMDNSLYVLD NNVVLQISEN HQVRIVAGRP
MHCQVPGIDH FLLSKVAIHA TLESATALAV SHNGVLYIAE TDEKKINRIR QVTTSGEISL
VAGAPSGCDC KNDANCDCFS GDDGYAKDAK LNTPSSLAVC ADGELYVADL GNIRIRFIRK
NKPFLNTQNM YELSSPIDQE LYLFDTSGKH LYTQSLPTGD YLYNFTYTGD DDITFITDNN
GNRVDISRDS TGMPLWLVGP DGQVYWMTMG TNSALRSVTT QGHELAMMTY HGNTGLLATK
SNENGWTTFY EYDSFGRLTN VTFPTGQVSS FRSDTDSSVH VQVETSSKDD VTITTNLSAS
GAFYTLLQDQ VRNSYYIGAD GSLRLLLANG MEVALQTEPH LLAGTVNPTV GKRNVTLPID
NGLNLVEWRQ RKEQARGQVT VFGRRLRVHN RNLLSLDFDR VTRTEKIYDD HRKFTLRILY
DQAGRPSLWS PSSRLNGVNV TYSPRGHIAG IQRGIMSERM EYDQTGRITS RIFADGKTWS
YTYLEKSMVL LLHSQRQYIF EFDKNDRLSS VTMPNVARQT LETIRSVGYY RNIYQPPESN
AFVIQDFTED GHLLHTSYLG TGRRVIYKYG KLSKLAEMLY DTTKVSFTYD ETAGMLKTIN
LQNEGFTCTI RYRQIGPLID RQIFRFTEEG MVNARFDYNY DNSFRVTSMQ AVINETPLPI
DLYRYDDVSG KTEQFGKFGV IYYDINQIIT TAVMTHTKHF DAYGRMKEVQ YEIFRSLMYW
MTVQYDNMGR VVKKELKVGP YANTTRYSYE YDADGQLQTV SINDKPLWRY SYDLNGNLHL
LSPGNSARLT PLRYDHRDRI TRLGDVQYKM DEDGFLRQRG ADVFEYNSAG LLTKAYNRAG
GWSVKYRYDG LGRRVSSKSS QGHHLQFFYA DLTNPTKVTH LYNHSSSEIT SLYYDLQGHL
FAMELSSGDE FYIACDNIGT PLAVFSGTGL MIKQVLYTAY GEIYMDTNPN FQIIIGYHGG
LYDPLTKLVH MGRRDYDVLA GRWTSPDHEL WKHLSSSNIM PFNLYMFKNN NPISNSQDIK
CFMTDVNSWL LTFGFQLHNV IPGYPKPDMD AMEPSYELVH TQMKTQEWDN SKSILGVQCE
VQKQLKAFVT LERFDQLYGS TITSCQQASK TTKFASSGSV FGKGVKFALK DGRVTTDIIS
VANEDGRRVA AILNNAHYLE DLHFTIGGVD THYFVKPGPS EGDLAILGLS GGRRTLENGV
NVTVSQINTM LNGRTRRYTD IQLQYGALCL NTRYGTTLDE EKARVLELAR QRAVRRAWAR
EQQRLREGEE GLRAWTEGER QQVLDTGRVQ GYDGFFVISV EQYPELSDSA NNIHFMRQSE
MGRR
//
