ID G1PIZ0_MYOLU Unreviewed; 1182 AA.
AC G1PIZ0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Stonin 1 {ECO:0000313|Ensembl:ENSMLUP00000010697.2};
GN Name=STON1 {ECO:0000313|Ensembl:ENSMLUP00000010697.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010697.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010697.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010697.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Stoned B family.
CC {ECO:0000256|ARBA:ARBA00005579}.
CC -!- SIMILARITY: Belongs to the TFIIA subunit 1 family.
CC {ECO:0000256|ARBA:ARBA00010059}.
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DR EMBL; AAPE02005131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02005132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02005133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02005134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02005135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PIZ0; -.
DR STRING; 59463.ENSMLUP00000010697; -.
DR Ensembl; ENSMLUT00000011743.2; ENSMLUP00000010697.2; ENSMLUG00000011744.2.
DR eggNOG; KOG2652; Eukaryota.
DR eggNOG; KOG2677; Eukaryota.
DR GeneTree; ENSGT00940000158817; -.
DR HOGENOM; CLU_008237_0_0_1; -.
DR InParanoid; G1PIZ0; -.
DR OMA; CSANPGN; -.
DR TreeFam; TF318623; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005672; C:transcription factor TFIIA complex; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd07976; TFIIA_alpha_beta_like; 2.
DR Gene3D; 1.10.287.100; -; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR Gene3D; 2.30.18.10; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR012320; SHD_dom.
DR InterPro; IPR004855; TFIIA_asu/bsu.
DR InterPro; IPR009088; TFIIA_b-brl.
DR PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR PANTHER; PTHR10529:SF339; STONIN-1; 1.
DR Pfam; PF00928; Adap_comp_sub; 1.
DR Pfam; PF03153; TFIIA; 1.
DR SMART; SM01371; TFIIA; 1.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR SUPFAM; SSF47396; Transcription factor IIA (TFIIA), alpha-helical domain; 1.
DR SUPFAM; SSF50784; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR PROSITE; PS51072; MHD; 1.
DR PROSITE; PS51070; SHD; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 274..407
FT /note="SHD"
FT /evidence="ECO:0000259|PROSITE:PS51070"
FT DOMAIN 411..718
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1054..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1182 AA; 131676 MW; AA602937B9C938F2 CRC64;
MCSTNPGNWV TFDDDPTFQS SQKSKNFRPE NQGICRPNGL KLNLSTPKEF SSGSSSTNST
PLPSPIIDFY FSPGPPSNSP LSTPTKDFPG IPGIPKAGTH VLYPIPELSS NSPLTTPGAD
SSLLSTKLTC VPHASLPDDH SCTPPAPKVG LPDEVSPPQA ESLGFQSDAL QFQYFQEDCA
FSSPFWKEEG SASQFTFDPP GSRKGFPSRD KEMPIDQKSL NQCSLNYICK KLEHLQSVED
QDSFGSLSMQ CLYAEDTGSS FVPHTLFRSQ PKPGWSFMLR IPEKKNMMSS RQWGPIFLKV
LPGGILQMYY EKGLEKPFKE LQLDSQCRLS EPKLENFSVA GKIHTVKIEH VSYTEKRKYH
SKTEVVHEPD IEQMLKLGST EYHDFLDFLT TVEEELMKLP AVSKPKKNYE EQEISLEIVD
NFWGKITKEE GKLVESAVIT QICCLCFVNG NSECFLTLND LELQKRNEHY FETDPEKKGI
DILEYHFHKC VKAQEFEQSR IIKFVPLDAC RFELMRFKTL YNGEDLPFSL KSVVVVQGAY
VELQAFVNMT PLLQKSSHAS SLRSCDNIMI HFPVPSQWIK ALWTMNLQRQ KSLKAKMNRP
ACLGSLHEPE SEPVIQVTVG SAKYESAYRA VVWKIDRLPD KHSSPDHPHC LSYKLELGSD
QEIPSDWYPF ATVQFGMLDT CASRTEVRSL GVESDVQPQK HVHQRACYNI QPKLYRSVIE
DVIEGVRDLF AEEGIEEHVL KDLKQLWETK ILQSKATEDF FRNSIHSPLF TLQLPHSLHQ
TLQSTAASLV IPAGRTLPSL TTAELSTANS SANFAFPGYP IHVPAGVTLQ TASGYLYKVN
VPIAVTQTSG RAGILQHPIQ QVFQQLGQPS IIQTSVPQLN PCSLQAAIEK SQRMETVLQQ
PTILHSGTVD RKHLENATSD ILVLPGNEHK IMSEALLSQP ASSQYVSLPG VGVPPQVSQR
DANVESLLSV SASGTQNLHG GPIATGPQGA QHQHSSDGQL HFLKNRMLGC DSVKQPINTE
EPSSLPVSEK DYNSQVGLSI QVPDEDIYEI IQIDGTGDTS SNDEIGSTRD ADEHEVLEII
DARDLKVLEG EADNISNGDS TTNSSDNEDP QIDIVEEDPL NSGDDVSEQD VPDLFDTDNV
IVCQYDKIHR SKNKWKFYLK DGVMCFGGRD YVFAKAIGDA EW
//
