ID G1PKV1_MYOLU Unreviewed; 3654 AA.
AC G1PKV1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=CUB and Sushi multiple domains 3 {ECO:0000313|Ensembl:ENSMLUP00000011454.2};
GN Name=CSMD3 {ECO:0000313|Ensembl:ENSMLUP00000011454.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011454.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000011454.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000011454.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; AAPE02009411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02009412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02009413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02009414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02009415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02009416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02009417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02009418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02009419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02009420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000011454; -.
DR Ensembl; ENSMLUT00000012588.2; ENSMLUP00000011454.2; ENSMLUG00000012541.2.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000155549; -.
DR HOGENOM; CLU_000277_0_0_1; -.
DR InParanoid; G1PKV1; -.
DR OMA; AVNTNKX; -.
DR TreeFam; TF316872; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0050773; P:regulation of dendrite development; IEA:Ensembl.
DR CDD; cd00033; CCP; 28.
DR CDD; cd00041; CUB; 14.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 28.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 14.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656:SF4; PROTEIN BETA CHAIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR Pfam; PF00431; CUB; 14.
DR Pfam; PF00084; Sushi; 28.
DR SMART; SM00032; CCP; 28.
DR SMART; SM00042; CUB; 14.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 28.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 14.
DR PROSITE; PS01180; CUB; 14.
DR PROSITE; PS50923; SUSHI; 28.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3578..3599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..116
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 119..180
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 184..288
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 427..488
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 491..602
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 605..662
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 664..772
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 775..836
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 838..946
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 951..1008
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1010..1120
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1123..1182
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1184..1292
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1295..1355
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1357..1466
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1469..1529
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1533..1641
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1644..1705
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1707..1816
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1822..1883
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1885..1993
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1996..2055
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2057..2165
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2168..2227
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2229..2340
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2339..2400
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2402..2513
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2513..2575
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2576..2637
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2638..2702
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2703..2760
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2761..2818
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2819..2876
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2877..2938
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2939..2996
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3000..3057
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3058..3116
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3117..3176
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3177..3234
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3236..3293
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3297..3355
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3356..3415
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 339..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 633..660
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 979..1006
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1357..1384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2731..2758
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2789..2816
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2847..2874
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2909..2936
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2967..2994
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3028..3055
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3087..3114
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3205..3232
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3264..3291
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3326..3353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 3654 AA; 399452 MW; 0FBB6179E72F52B7 CRC64;
VAGFIYTCGG TLKGLNGTIE SPGFPYGYPN GANCTWVIIA EERNRIQIVF QSFALEEEYD
YLSLYDGHPH PTNFRTRLTG FHLPPPVTST KSVFSLRLTS DFAVSAHGFK VYYEELQSSS
CGNPGVPPKG VLYGTRFDVG DKIRYSCVTG YILDGHPQLT CIANTVNTAS WDFPVPICRA
EDACGGTMRG SSGIISSPSF PNEYHNNADC TWTIVAEPGD TISLIFTDFQ MEEKYDYLEI
EGSEPPTIWL SGMNIPPPII SNKNWLRLHF VTDSNHRYRG FSAPYQGSST LTLTTSTGEL
EEHNRTATGA IAVASTSADV TVSSVTAVTI HRLSEEQRVQ VTNLRNAGLD PNTSKDGLSP
HQADTQSTRR RPRNAEQIER TNELAVVTHR VKKAIDFKSR GFKLFPGKDN SNKFSILNEG
GIKTASNLCP DPGEPENGKR VGSDFSLGST VQFSCDEDYV LQGAKSITCQ RIAEVFAAWS
DHRPVCKVKT CGSNLQGPSG TFTSPNFPFQ YDSNAQCVWV ITAVNTNKVI QINFEEFDLE
IGYDTLTIGD GGEVGDPRTV LQVLTGSFVP DLIVSMSSQM WLHLQTDESV GSVGFKVNYK
EIEKESCGDP GTPLYGIREG DGFSNRDVLR FECQFGFELI GEKSIVCQEN NQWSANIPIC
IFPCLSNFTA PMGTVLSPDY PEGYGNNLNC IWTIISDPGS RIHLSFNDFD LESQFDFLAV
KDGDSPDSPI LGTFTGAEVP SHLTSNSHIL RLEFQADHSM SGRGFNITYN TFGHNECPDP
GIPINARRFG DNFQLGSSIS VICEEGFIKT QGTETITCIL MDGKVMWSGP IPRCGAPCGG
HFSAPSGLIL SPGWPGYYKD SLNCEWVIEA EPGHSIKITF ERFQTELNYD VLEVHDGPNL
LSPLLGSYNG TQVPQFLFSS SNFIYLLFTT DNSRSNNGFK IHYESVTVNT YSCLDPGIPV
HGRRYGHDFS IGSTVSFSCD PGYRLSHEEP LLCEKNHWWS HPLPTCDALC GGDVRGPSGT
ILSPGYPEFY PNSLNCTWTV DVTHGKGVQF NFHTFHLEDH HDYLLITENG SFTQPLARLT
GSELPSTINA GLYGNFRAQL RFISDFSISY EGFNITFSEY NLEPCEDPGI PQYGNRIGFN
FGVGDTLTFS CSSGYRLEGT SEIICLGGGR RVWSAPLPRC VAECGASATN NEGILLSPNY
PLNYENNHEC IYSIQVQAGK GINISARTFH LAQGDVLKIY DGKDKTTHLL GAFTGASMRG
LTLSSTSNQL WLEFNSDSEG TDEGFQLVYT SFELSHCEDP GIPQFGYKIS DQGHFAGSTI
IYGCNPGYTL HGSSLLKCMT GERRAWDYPL PSCIAECGGR FKGESSGRIL SPGYPFPYDN
NLRCMWMIEV DPGNIVSLQF LAFDTEASHD ILRVWDGPPE NEMLLKEISG SLIPEGIHST
LNIVTIQFDT DFYISKSGFA IQFSSSVATA CRDPGVPMNG TRNGDGREPG DTVVFQCDPG
YELQGEERIT CIQVENRYFW QPSPPVCIVK APCGGNLTGS SGFILSPNFP HPYPHSRDCD
WTITVNTDYV ISLAFISFSI EPNYDFLYIH DGPDSNSPLI GSFQDSKLPE RIESSSNTMH
LAFRSDGSVS YTGFHLEYKA KLRESCFDPG NIMNGTRLGM DYKLGSTVTY YCDAGYVLQG
YSTLTCIMGD DGRPGWNRAL PSCHAPCGSR STGSEGTVLS PNYPKNYSVG HNCVYSIAVP
KEFVVFGQFV FFQTSLHDVV EVYDGPTQQS SLLSSLSGSH SVGESLPLSS GNQITIRFTS
VGPITAKGFH FVYQAVPRTS STQCSSVPEP RFGRRIGNEF AVGSLVLFEC NPGYILHGSI
AIRCDTVPNS LAQWNDSLPT CIVPCGGILT KRKGTILSPG YPEPYDNNLN CVWKITVPEG
AGIQVQVVSF ATEHNWDSLD FYDGGDNNAP RLGSYSGTTI PHLLNSTSNN LYLNFQSDIS
VSAAGFHLEY TAIGLDSCPE PQTPSNGIKI GDRYMVGDVV SFQCDQGYSL QGHSHITCMP
GPVRRWNYPI PICLAQCGGA MSDFSGVILS PGFPGNYPSS LDCTWTVKLP VGFGVHLQFV
NFSTETIHDY LEVRSGTSET STVIGRLSGP QIPSSLFSTT HETSLYFHSD YSQNKQGFHI
VYQAYQLQSC PDPRPFRNGF VIGSDFTVGQ TVSFECFPGY TLIGNSALTC LHGVSRNWNH
PLPRCEALCG GNITAMNGTI YSPGYPDEYP NFQDCFWLVR VPPGNGIYIN FTVLQTEPVY
DFITVWDGPD QNSPQIGQFS GNTALESVYS TSNQILIKFH SDFTTSGFFV LSYHAYQLRV
CQPPPPVPNA EILTEDDEFE IGDIIRYQCL PGFSLVGNAI LTCRLGERLQ MDGAPPVCQV
LCPANELRLD STGVILSPGY PDSYPNLQMC AWSISVEKGY NISMFVEFFQ TEKEFDVLQV
YDGPNIQSPL LISLSGDYSS AFNITSNGHE VFLQWSADHG NNKKGFRIRY IAFYCSTPES
PPHGYIISQT GGQLNSVVRW ACDRGFRLVG KSSAVCRKSS YGYHAWDAPV PACQAISCGI
PKAPTNGGIL TTDYLVGTRV TYFCHDGYRL SSKELTTAVC QSDGTWSNHN KTPRCVVVTC
PSINSFTLEH GRWRIVNGSH YEYKTKVVFS CDPGYHGLGP ASIECLPNGT WSWRNERPYC
QIISCGELPT PPNGNKIGTQ TSYGSTAIFT CDAGFILVGS AVRECLSSGL WSGSETRCLA
GHCGIPELIV NGQVIGENYG YRDTVVYQCN PGFRLIGSSV RICQQDHNWS GQLPSCVPVS
CGHPGSPIYG RTSGNGFNFN DVVTFSCNIG YLMQGPTKAQ CQANRQWSHP PPVCKVVNCS
DPGIPPNSKR ESKIEHGNFT YGTVVFYDCN PGYFLFGSSV LICQPNGHWD KPLPECIMID
CGHPGVPPNA VLSGEKYTFG STVHYSCTGK RSLLGHSSRT CQLNGHWSGS QPHCSGDATG
TCGDPGTPGH GSRQESNFRT QSSVHFACDT GYILHGSEER TCLANGSWTG RQPECKAVQC
GNPGTTANGK VFRIDGTTFS SSIIYSCIEG YILSGPSVRQ CTANGTWSGT LPNCTIISCG
DPGIPANGLR YGDDYVVGHN VSYMCQPGYT MELNGSRIRT CTTNGTWSGV MPTCRAVTCA
TPPQISNGRL EGTNFDWGFS ISYICSPGYE LSFPAVLTCV GNGTWSGEGM QCSPPKFCGD
PGTPAQGKRE GKSFIYQSEV AFSCNSPFIL VGASTRICQA DGTWSGSSPH CIEPTRTSCE
NPGVPRHGSQ NSTFGFQVGS VLQFHCKKGH LLQGSTTRTC LPDLTWSGIQ PECIPHSCKQ
PETPVHANVV GMDLPSHGYT LVYTCQPGFF LAGGTEHRVC RSDNTWTGKV PVCEAGSKIL
VKDPRPALGT PSPKLSVPDD VFAQNYIWKG SYNFKGRKQP MTLTVTSFNA STGRVNATLS
NSNMELLLSG VYKSQEARLM LHIYLIKVPA HASVKKMKEE SWAMDGFVSA EPDGATYVFQ
GFIQGKDYGQ FGLQRLGLNM SEGLNSSNQP HGTNSSSVAI AILVPFFALI FAGFGFYLYK
QRTAPKTQYT GCSVHENNNG QAAFENPMYD TNAKSVEGKA VRFDPNLNTV CTMV
//
