ID G1PN42_MYOLU Unreviewed; 327 AA.
AC G1PN42;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Nuclear apoptosis-inducing factor 1 {ECO:0000256|ARBA:ARBA00014166};
GN Name=NAIF1 {ECO:0000313|Ensembl:ENSMLUP00000012341.1};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000012341.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000012341.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000012341.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Induces apoptosis. {ECO:0000256|ARBA:ARBA00003564}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NAIF1 family.
CC {ECO:0000256|ARBA:ARBA00010629}.
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DR EMBL; AAPE02044236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006102136.1; XM_006102074.2.
DR AlphaFoldDB; G1PN42; -.
DR STRING; 59463.ENSMLUP00000012341; -.
DR Ensembl; ENSMLUT00000013561.1; ENSMLUP00000012341.1; ENSMLUG00000013565.1.
DR GeneID; 102441777; -.
DR KEGG; mlf:102441777; -.
DR CTD; 203245; -.
DR eggNOG; ENOG502QW9U; Eukaryota.
DR GeneTree; ENSGT00450000040324; -.
DR HOGENOM; CLU_078961_0_0_1; -.
DR InParanoid; G1PN42; -.
DR OMA; QQDGMIQ; -.
DR OrthoDB; 4271806at2759; -.
DR TreeFam; TF332812; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:1902108; P:regulation of mitochondrial membrane permeability involved in apoptotic process; IEA:Ensembl.
DR InterPro; IPR028002; Myb_DNA-bind_5.
DR PANTHER; PTHR23098; AGAP001331-PA-RELATED; 1.
DR PANTHER; PTHR23098:SF7; NUCLEAR APOPTOSIS-INDUCING FACTOR 1; 1.
DR Pfam; PF13873; Myb_DNA-bind_5; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 8..85
FT /note="Myb/SANT-like DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF13873"
FT REGION 88..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 35184 MW; A8BD5373BD677B63 CRC64;
MAVPAKKRKM NFSEREVEII VEELELKKHL LVNHFNAGVP LAAKSAAWHG ILRRVNAVAT
CRRELPEVKK KWSDLKTEVR RKVAQVRAAV EGGEAPGPNE EDGAGGPGPG GSSSGGGPAV
APVLLTPMQQ RICNLLGEAT IISLPSATEI HPVALGPTAT AAAATVTLTQ IPTETTYHTL
EEGVVEYCTA EAPPPLPAEA PVEMIAQHAD PSVKPQALKS RIALNSAKLI QEQRVTNLHV
KEIAQHLEQQ NDLLQMIRRS QEVQACAQER QAQAMEGTQA ALSVLIQILR PMIKDFRRYL
QSNTSNPAPA SDPGQMAQNG QPDSIIP
//
