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Database: UniProt
Entry: G1PPG7_MYOLU
LinkDB: G1PPG7_MYOLU
Original site: G1PPG7_MYOLU 
ID   G1PPG7_MYOLU            Unreviewed;      2005 AA.
AC   G1PPG7;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 46.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1C {ECO:0000313|Ensembl:ENSMLUP00000012900};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000012900, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000012900, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000012900}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000012900}.
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DR   EMBL; AAPE02024292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02024293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02024294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02024295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000012900; -.
DR   Ensembl; ENSMLUT00000014180; ENSMLUP00000012900; ENSMLUG00000014160.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; G1PPG7; -.
DR   OMA; PTTKINM; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:1990454; C:L-type voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0051393; F:alpha-actinin binding; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0061577; P:calcium ion transmembrane transport via high voltage-gated calcium channel; IEA:Ensembl.
DR   GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR   GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0002520; P:immune system development; IEA:Ensembl.
DR   GO; GO:0098912; P:membrane depolarization during atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005451; VDCC_L_a1csu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 2.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01635; LVDCCALPHA1C.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM      6     26       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     38     56       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    109    131       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    190    211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    223    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    391    408       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    428    446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    517    539       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    593    619       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    767    786       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    798    820       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    840    863       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    884    917       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1009   1035       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1086   1103       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1115   1137       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1225   1248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1318   1342       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1476   1510       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      622    648       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2005 AA;  225989 MW;  F3412D60B53392DF CRC64;
     ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS AILEQATKAD
     GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI
     IIYAIIGLEL FMGKMHKTCY NQEGIADVPA EDDPSPCALE TGHGRQCQNG TVCKPGWDGP
     RHGITNFDNF AFAMLTVFQC ITMEGWTDVL YWMQDAMGYE LPWVYFVSLV IFGSFFVLNL
     VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDEE
     KPRNRGAAAG LLDQKKGKFA WFSHSTETHV SMPTSETESV NTENVAGGDI EGENCGARLA
     HRISKSKFSR YWRRWNRFCR RKCRAAVKSN VFYWLVIFLV FLNTLTIASE HYNQPHWLTE
     VQDTANKALL ALFTAEMLLK MYSLGLQAYF VSLFNRFDCF IVCGGILETI LVETKVMSPL
     GISVLRCVRL LRIFKITRYW NSLSNLVASL LNSVRSIASL LLLLFLFIII FSLLGMQLFG
     GKFNFDEMQT RRSTFDNFPQ SLLTVFQILT GEDWNSVMYD GIMAYGGPSF PGMLVCIYFI
     ILFICGNYIL LNVFLAIAVD NLADAESLTS AQKEEEEEKE RKKLARTASP EKKQEVVEKP
     AVEETKEEKI ELKSITADGE SPPTTKINMD DLQPNENEDK GVYPNPEATG EEDEEEPEMP
     VGPRPRPLSE LHLKEKAVPM PEASAFFIFS PSNRFRLQCH RIVNDSIFTN LILFFILLSS
     ISLAAEDPVQ HTSFRNHILY YFDIVFTTIF TIEIALKMTA YGAFLHKGSF CRNYFNILDL
     LVVSVSLISF GIQSSAINVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIVI
     VTTLLQFMFA CIGVQLFKGK LYTCSDSSKQ TEAECKGNYI TYKDGEVDHP IIQPRNWENS
     KFDFDNVLAA MMALFTVSTF EGWPELLYRS IDSHTEDKGP IYNYRVEISI FFIIYIIIIA
     FFMMNIFVGF VIVTFQEQGE QEYKNCELDK NQRQCVEYAL KARPLRRYIP KNQHQYKVWY
     VVNSTYFEYL MFVLILLNTI CLAMQHYGQS CVFKIAMNVL NMLFTGLFTV EMILKLIAFK
     PKGYFSDPWN VFDFLIVIGS IIDVILSETN PAEHTQCSPS LNAEENSRIS ITFFRLFRVM
     RLVKLLSRGE GIRTLLWTFI KSFQALPYVA LLIVMLFFIY AVIGMQVFGK IALNDTTEIN
     RNNNFQTFPQ AVLLLFRCAT GEAWQDIMLA CMPGKKCAPE SEPHNSTEGE APCGSSFAVF
     YFISFYMLCA FLIINLFVAV IMDNFDYLTR DWSILGPHHL DEFKRIWAEY DPEAKGRIKH
     LDVVTLLRRI QPPLGFGKLC PHRVACKRLV SMNMPLNSDG TVMFNATLFA LVRTALRIKT
     EGNLEQANEE LRAIIKKIWK RTSMKLLDQV VPPAGDDEVT VGKFYATFLI QEYFRKFKKR
     KEQGLVGKPS QRNALSLQAG LRTLHDIGPE IRRAISGDLT AEEELDKAMK EAVSAASEDD
     IFRRAGGLFG NHVSYYQSDS RSTFPQTFTT QRPLHINKAT NSPGHTESPS HEKLVDSTFT
     PSSYSSTGSN ANINNANNTA LGRFPRPTRY PSSVSAVEGH GPPLSPAIRV QEAAWKLSSK
     RCHSRESQIA MVCREEFSQD ETYDVQMGDD AEYCSEPSLV STDKLSYQDE ESRQLAPPED
     RRDTRQSPKR GFLRSASLGR RASFHLECLK RQKNQGGDIS QKTVLPLHLV HHQALAVAGL
     SPLLQRSHSP TTFPRPCATP PATPSSRGWP PQPIPTLRLE GTESTEKLNS SFPSVHCSSW
     SGEPTPCEGG SSATRRARPV SLTVPSQAGA WGRQFHGSAS SLVEAVLISE GLGQFAQDPK
     FIEVTTQELA DACDMTIEEM ENAADNILSG GAQQSPNGTL LPFVNCRDQG QDRAGGEEPG
     PCGPSQEPQR SEEELQDSRA YVSSL
//
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