ID G1PPY2_MYOLU Unreviewed; 1945 AA.
AC G1PPY2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Anaphase promoting complex subunit 1 {ECO:0000313|Ensembl:ENSMLUP00000013098.2};
GN Name=ANAPC1 {ECO:0000313|Ensembl:ENSMLUP00000013098.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013098.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013098.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013098.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the APC1 family.
CC {ECO:0000256|ARBA:ARBA00010547}.
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DR EMBL; AAPE02041680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02041681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000013098; -.
DR Ensembl; ENSMLUT00000014405.2; ENSMLUP00000013098.2; ENSMLUG00000014399.2.
DR eggNOG; KOG1858; Eukaryota.
DR GeneTree; ENSGT00390000016757; -.
DR HOGENOM; CLU_001202_1_0_1; -.
DR InParanoid; G1PPY2; -.
DR OMA; MQPPDSR; -.
DR TreeFam; TF105441; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:Ensembl.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR024990; Apc1.
DR InterPro; IPR048971; Apc1_3rd.
DR InterPro; IPR041221; APC1_C.
DR InterPro; IPR046794; Apc1_MidN.
DR InterPro; IPR049255; Apc1_N.
DR InterPro; IPR011989; ARM-like.
DR PANTHER; PTHR12827:SF3; ANAPHASE-PROMOTING COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR12827; MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER; 1.
DR Pfam; PF12859; ANAPC1; 2.
DR Pfam; PF21282; APC1_3rd; 1.
DR Pfam; PF18122; APC1_C; 1.
DR Pfam; PF20518; Apc1_MidN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 85..202
FT /note="Anaphase-promoting complex subunit 1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12859"
FT DOMAIN 588..663
FT /note="Anaphase-promoting complex subunit 1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12859"
FT DOMAIN 665..984
FT /note="Anaphase-promoting complex subunit 1 middle"
FT /evidence="ECO:0000259|Pfam:PF20518"
FT DOMAIN 1618..1703
FT /note="Anaphase-promoting complex subunit 1 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF21282"
FT DOMAIN 1737..1896
FT /note="Anaphase-promoting complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18122"
FT REGION 305..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1945 AA; 216424 MW; 8F52AAC3A27FD33F CRC64;
MSNFYEERAT MIAAGDLQEF VPFGRDHCKH HPNALNLQLR QLQPASELWS SDGAAGLVGS
LQEVTLHEKQ KESWQLRRGG SEIGEVDYDE ELYVAGNMVI WSKGSKSQAL AVYKAFTVDS
PVQQALWCDF IISQDKSEKA YSSAEVEKCI CILQSSCINM HSIEGKDYIA SLPFQVANVW
PTKYGLLFER SSSSHEIPPG PPREPLPTMF SMLHPLDEIT PLVCKSGSLF GSSRVQYVVD
HAMKIVFLST DPSIVMTYDT VQCLHSVWVL RRVKAEEENA VLKFSEQGGT PQNVAPSSSL
TANLRSLSKG DSPVASPFQN YSSIHSQSRS TSSPSLHSRS PSISNMAALS RAHSPASGVH
SFTGVQRFNL SSHNQSPRRH SISHSPDSNS NSSFLAPETE PIVPELCIDH LWTEAITNIR
EKNSQASKVF ITSDLCGQKF LCFLVESQLQ LRCVKFQESN DKTQLIFGSI TNIQAKDAAP
VEKIDTMLVL ESSGNLVLYT GVVRVGKVFI PGLPAPSLTM SNAMPRPSTP LDSVSTPTPL
SKLLGTLDEV VLLSPVPELR DSSKLHDSLY NEDCTFQQLG TYIHSIRDPV RNRVTLELSN
GSMVRITLPE IATSELVQTC LQAIKFILPK EIAVQMLVKW YSVHSAPGGP SYHSEWNLFV
ICLMNMMGYN TDRLAWTRNF DFEGSLSPVI APKKARPSET GSDEDWEYLL NSDYHQKVES
HLLNRSLCLS PLEVSQIKDE DLSQNLSLDS STLLFSHIPA MFFVLHLVYE ELKLNTLMGE
GIHSLVDLLV QLARDLKLEP YLDHYYRDYP TLVRTTGQVC TIDQGQTGFM HHPSFFTSEP
PSIYQWVSSC LKGEEMPPYP YLPGICERSR LVVLSIALYI LGDESSVCDE SSHYLSRISL
APQKSQAEQE ENRFSFRHSP SVSSLAERLV VWMANVGFTL RDLETLPFGI ALPIRDAIYH
CREQPAADWP EAVCLLIGRQ DLSKQACEGN LPKGKSVLSS DVPSGTETEE EDDGMNDMNQ
EVMSLIWSED LRVQDVRRLL QSAHPVRVNV VQYPELSDHE FIEEKENRLL QLCQRTMALP
VGRGMFTLFS YHPVPTEPLP IPKLNLTGIG RAPPRNTTVD LNSGNIDVPP NMTSWASFHN
GVAAGLKIAP ASQIDSAWIV YNKPKHAELA NEYAGFLMAL GLNGHLTKLA TLNIHDYLTK
GHEMTSIGLL LGVSAAKLGT MDMSITRLLS IHIPALLPPT STELDVPHNV QVAAVVGIGL
VYQGTAHRHT AEVLLAEIGR PPGPEMEYCT DRESYSLAAG LALGMVCLGH GSNLIGMSDL
NVPEQLYQYM VGGHRRFQAG MHREKHKSPS YQIKEGDTIN VDVTCPGATL ALAMIYLKTN
NRSIADWLRA PDTMYLLDFV KPEFLLLRTL ARCLILWDDI LPNSKWVDSN VPQIIRENSI
SLSEIELPCS EDLNLETLSQ AHVYIIAGAC LSLGFRFAGS ENLSAFNCLH KFAKDFMTYL
SAPNASVTGP YNLETCLSVV LLSLAMVMAG SGNLKVLQLC RFLHMKTGGE MNYGFHLAHH
MALGILFLGG GRYSLSTSNS SIAALLCALY PHFPAHSTDN RYHLQALRHL YVLAAEPRLL
VPVDVDTNTP CYALLEVTYK GTQWYEQTKE ELMAPTLLPE LHLLKQIKVK GPRYWELLID
LSKGTQHLKS ILSKDGVLYV KLRAGQLSYK DDPMGWQSLL AQTVANRNSE ARAFKPETIS
AFTSDPALLS FAEYFCKPTV NMGQKQELLD LFSSVLYECV TQETPEMLPA YIAMDQAVRR
LGRREMSETS ELWQIKLVLE FFSSRSHQER LQTHPKRGLF MNSEFLPVVK CSIDNTLDQW
LQAGGDVCLH AYLSGQPWEE SQLSMLACFL VYHSVPAPRH LPSVGLEGST SFAELLFKCK
QLKMPVRALL RLAPLLLGNP QPMVM
//
