ID G1PQU5_MYOLU Unreviewed; 1073 AA.
AC G1PQU5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Transient receptor potential cation channel subfamily A member 1 {ECO:0000313|Ensembl:ENSMLUP00000013474.2};
GN Name=TRPA1 {ECO:0000313|Ensembl:ENSMLUP00000013474.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013474.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013474.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013474.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02012757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02012758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PQU5; -.
DR STRING; 59463.ENSMLUP00000013474; -.
DR Ensembl; ENSMLUT00000014806.2; ENSMLUP00000013474.2; ENSMLUG00000014797.2.
DR eggNOG; KOG0510; Eukaryota.
DR GeneTree; ENSGT00940000156118; -.
DR HOGENOM; CLU_006750_0_0_1; -.
DR InParanoid; G1PQU5; -.
DR OMA; HWATEKN; -.
DR TreeFam; TF317264; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032421; C:stereocilium bundle; IEA:Ensembl.
DR GO; GO:0015278; F:calcium-release channel activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0097604; F:temperature-gated cation channel activity; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
DR GO; GO:0071310; P:cellular response to organic substance; IEA:Ensembl.
DR GO; GO:0050968; P:detection of chemical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR GO; GO:0009409; P:response to cold; IEA:Ensembl.
DR GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.
DR GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0050955; P:thermoception; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 6.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR47143; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS; 1.
DR PANTHER; PTHR47143:SF3; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 13.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 8.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 687..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 727..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..852
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 898..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 64..96
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 131..163
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 205..237
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 308..340
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 379..411
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 412..444
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 448..473
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 515..547
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 714..930
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1040..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1073 AA; 121962 MW; FE5A1D844EB1666C CRC64;
LFEVVFEGNA NELQSCLKKP KKPHKYDDVN ASPLHYAAEE GDIGLMEMII NDSSCEVLNV
MDNDGNTPLH WAAEKNQVES VRFLLSKGAN PNLQNNSMMA PLHLAVQGMH NEVVKVLIEH
SGTNINLEGE NGNTAVIIAC SRDNSEALQI LLRHGAKPCK SNKWGCFPVH QAAFSGAKKC
MEIILKFGEE NGYDRQFHIN FVNNGKASPL HLAVQSGDLG MIKMCLDNGA QVELMENGKC
TALHFAATQG ATEIVKLMIN SYSGSSDIVN AVDGNQETLL HRQVSYSHSV YRLSVFSQGA
DINSTDSEGR SPLLLATASA SWNIVNLLLS RGAQVDIKDH LGRNFLHLTV QQPYGLSNLQ
PEFMQMQHIK ELVMDEDNDG CTPLHYACRQ GVPASVNNLL GFNVSIHSKS KDKQSPLHFA
ASYGRINTCQ RLLRDMNDTR LLNEGDLHGM TPLHLAAKNG HDKVVQLLLR KGALFLSDHS
GWTALHHASL GGYTQTMKVI LDTNLKCTTD QVDEDGNTAL HLAAREGHAK AAALLLNYDA
DILLNRQQAS FLHLAIHNKR KEVVLMTIRN RRWEECFRAF SHNSPSNKCP VVEMVEYLPE
CMKVLLDCCM TPSTEDKSCR DYHIEYNFRY LQCPLEFTKK NAQDVTYEPL TTINTMVHHN
RIELLNHPVC KEYLLMKWLA YGFRAHIMNL GSYCLGLLPM TFLVVNIKPG MAFNSNWHHS
NFLFKDSYSI KVCMILVFLS SLFGYCKELV QIFQQKRNYI LDQSNGTEWV IYTTSIIFVS
PLFISIPAHV QWQCGAIAIY FYWMNFLMYL QRFENCGIFI VMLEVIMKTL LRSTVVFIFL
LLAFGLSFYV LLSIQDAFST PLLSIIQTFS MMLGDINYRD AFLEPFLRNE LAYPLLSFIQ
LITFTMFVPI VLMNLLIGLA VGDIAEVQKH ALLKRIAMQV ELHTNLEKKL PLWFLRKVDQ
KSIIVYPNRA RYSRGLLCIF HQIFCTQEVR QEIPNADTAL EVEILKQKYR LKDVTSLLEK
QHELIKLIIQ KMEIISETED EDNHSSFQDR YKREQQEQRN SKWNSVLKAV RAR
//