ID G1PRC7_MYOLU Unreviewed; 348 AA.
AC G1PRC7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Src homology 2 domain containing transforming protein D {ECO:0000313|Ensembl:ENSMLUP00000013684.2};
GN Name=SHD {ECO:0000313|Ensembl:ENSMLUP00000013684.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013684.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013684.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013684.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02055966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006107157.1; XM_006107095.2.
DR AlphaFoldDB; G1PRC7; -.
DR STRING; 59463.ENSMLUP00000013684; -.
DR Ensembl; ENSMLUT00000015029.2; ENSMLUP00000013684.2; ENSMLUG00000015032.2.
DR GeneID; 102425011; -.
DR KEGG; mlf:102425011; -.
DR CTD; 56961; -.
DR eggNOG; ENOG502QUXW; Eukaryota.
DR GeneTree; ENSGT00940000159004; -.
DR HOGENOM; CLU_029444_0_1_1; -.
DR InParanoid; G1PRC7; -.
DR OMA; CRAVQLY; -.
DR OrthoDB; 2963819at2759; -.
DR TreeFam; TF325799; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR15127; HEAVYWEIGHT, ISOFORM A; 1.
DR PANTHER; PTHR15127:SF33; SH2 DOMAIN-CONTAINING ADAPTER PROTEIN D; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 237..332
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 348 AA; 38899 MW; C436B4CA0274B845 CRC64;
MAKWLRDYLS FGGRRPPPQP PTPDYTESDI LRAYLEQKNL DFEDPYEDAD SRLEPDSAGP
GDSKYDSPKH RLIKVEAADM AEVARAKVLL GSAGAESEVD TEYSDPFDAQ PHPPPPDDGY
MEPYDAQRVV SELPCRAVQL YDTPYEEQDG EPGDRPFSGQ RPGQSRQPQE DERPADEYDQ
PWEWKKDHIS KAFAVQFDSP EWERTPGSAK ELRKPPPRSP HLAERVDPAL PLEKQPWFHG
PLSRADAENL LLLCKEGSYL VRLSETSPQD CSLSLRSSQG FLHLKFAWTR ENQLVLGQHS
GPFASVPELV LHYSSRPLPV QGAEHLALLY PVVTQSPCPG ASAPGPAP
//
