ID G1PU59_MYOLU Unreviewed; 1311 AA.
AC G1PU59;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=AT-rich interaction domain 4B {ECO:0000313|Ensembl:ENSMLUP00000014805.2};
GN Name=ARID4B {ECO:0000313|Ensembl:ENSMLUP00000014805.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000014805.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000014805.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000014805.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02049895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000014805; -.
DR Ensembl; ENSMLUT00000016249.2; ENSMLUP00000014805.2; ENSMLUG00000016232.2.
DR eggNOG; KOG2744; Eukaryota.
DR eggNOG; KOG3001; Eukaryota.
DR GeneTree; ENSGT00940000158149; -.
DR HOGENOM; CLU_007419_0_0_1; -.
DR InParanoid; G1PU59; -.
DR OMA; XPEEESS; -.
DR TreeFam; TF106427; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd16883; ARID_ARID4B; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR InterPro; IPR012603; ARID4A/B_PWWP.
DR InterPro; IPR028853; ARID4B_ARID/BRIGHT.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR025995; Tudor-knot.
DR PANTHER; PTHR13964:SF24; AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4B; 1.
DR PANTHER; PTHR13964; RBP-RELATED; 1.
DR Pfam; PF01388; ARID; 1.
DR Pfam; PF08169; RBB1NT; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SMART; SM00333; TUDOR; 2.
DR SUPFAM; SSF46774; ARID-like; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS51011; ARID; 1.
PE 4: Predicted;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 304..396
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT REGION 121..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..1213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1251..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..304
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..564
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..755
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..887
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..924
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1311 AA; 146430 MW; 376EAB4BF73E0762 CRC64;
ALDEPPYLTV GTDVSAKYRG AFCEAKIKTA KRLVKVKVTF RHDSSTVEVQ DDHIKGPLKV
GAIVEVKNLD GTYQEAVINK LTDASWYTVV FDDGDEKTLR RSSLCLKGER HFAESETLDQ
LPLTNPEHFG TPVIGKKTNR GRRSNHIPEE ESSSSSSDED EDDRKQIDEL LGKVVCVDYV
SLDKKKALCF PALVVCPDCS DEIAVKKDNI LVRSFKDGKF TSVPRKDVHE ITSDTAPKPD
AVLKQAFDQA LEFHRSRTIP ANWKTELKED SSSSEAEEEE EEEEDEKEKE DNSSEEEEEI
EPFPEERENF LQQLYKFMED RGTPINKRPV LGYRNLNLFK LFRLVHKLGG FDNIESGAIW
KQVYQDLGIP VLNSAAGYNV KCAYKKYLYG FEEYCRSANI EFQMALPEKV ANKPCKECDS
VKEIKVKEES EPEMKEIKIE EEEKIIIKEE NPTEDDVERK ENIKPSLGSK KNLLESISTQ
SDQEKEVNLK KTEENENLVD KNDETTGLDE SLSIKVEAEE EKAKSGDETN KEEEEDDEEV
EEEEEEEEEE EDEEDDDNNE EEEFECYPPG MKVQVRYGRG KNQKMYEASI KDSDVEGGEV
LYLVHYCGWN VRYDEWIKAD KIVRPADKNV PKIKHRKKIK NKLDKEKDKD EKYSPKNCKL
RRLSKPPFQT NSSPEIVSKL DLTDAKNSDT AHIKSIEITS ILNGLQASES SEDSEQEDET
GAHDMDSTGK EESKTEYLAH ARNDLSKEEQ NSSFLLEESK VHADLVISKP ASKSPERLRK
DMEGLSEDTD YEEDEVTKKR KDVKKDTPDK SSKPQVKRGK RRYCNTEECA KTGSPSKKDE
KAKNKESLCV ENSSNSSSDE DEEEKSKAKL TPTKKYNGLE EKRKSLRTTG FYSGFSEVAE
KRIKLLNNSD ERLQNSRAKD RKDVWSSIQG QWPKKTLKEL FSDSDTEAAA SPPHPAPEEG
PAEGTLQTVA EEESSPGAEL DAPLPASADS QPAEEKPLEA SDKKAEFPSS GSNSVLNTPP
TTPESPSSVT VTEAGQQPSS VSASDALAPN QEEVRSIKSE TDSTIEVDSV AGELQDLQSE
GNSSPAGCDA SVSSSSSTQP EPEPSEKACT GQKRAKEAQG GGSSSKKQKR SHKATVVNNK
KKGKGTNSSD SEELSAGESV TKTQPVKSLS AGMKAHSAHS AKSPARTQSP GKCGKNGDKD
PDLKEPSNRL PKVYKWSFQM SDLENMTTAE RITILQEKLQ EIRKHYLSLK SEVASIDRRR
KRLKKKERES AATSSSSSSP SSSSITAAVM LTLAEPSMSS ASQNGMSVEC R
//
