GenomeNet

Database: UniProt
Entry: G1PW72_MYOLU
LinkDB: G1PW72_MYOLU
Original site: G1PW72_MYOLU 
ID   G1PW72_MYOLU            Unreviewed;      2018 AA.
AC   G1PW72;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 46.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1D {ECO:0000313|Ensembl:ENSMLUP00000015633};
OS   Myotis lucifugus (Little brown bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000015633, ECO:0000313|Proteomes:UP000001074};
RN   [1] {ECO:0000313|Ensembl:ENSMLUP00000015633, ECO:0000313|Proteomes:UP000001074}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMLUP00000015633}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000015633}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAPE02022356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02022357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02022358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02022359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02022360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02022361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPE02022362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59463.ENSMLUP00000015633; -.
DR   Ensembl; ENSMLUT00000017147; ENSMLUP00000015633; ENSMLUG00000017133.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; G1PW72; -.
DR   OMA; LIQVERP; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000001074; Unassembled WGS sequence.
DR   GO; GO:1990454; C:L-type voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0051393; F:alpha-actinin binding; IEA:Ensembl.
DR   GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0086059; F:voltage-gated calcium channel activity involved SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0051928; P:positive regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:1901016; P:regulation of potassium ion transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01636; LVDCCALPHA1D.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM      6     26       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     38     56       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    110    133       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    189    210       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    382    400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    420    443       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    512    531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    584    611       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    746    764       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    784    804       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    816    842       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    862    892       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    989   1014       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1068   1086       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1098   1118       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1208   1226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1300   1323       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1457   1491       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      614    645       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2018 AA;  228933 MW;  9255DC2D49FD3D76 CRC64;
     EKVEYAFLII FTVETFLKII AYGLLLHPNA YVRNGWNLLD FVIVIVGLFS VILEQLTKET
     EGGNHSGGKS GGFDVKALRA FRVLRPLRLV SGVPSLQVVL NSIIKAMVPL LHIALLVLFV
     IIIYAIIGLE LFIGKMHKTC FFADSDIVAE EDPAPCAFSG NGRQCIINGT ECRSGWVGPN
     GGITNFDNFA FAMLTVFQCI TMEGWTDVLY WVNDAIGWEW PWVYFVSLII LGSFFVLNLV
     LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEEEGGEESK
     RNTSMPTSET ESVNTENVSG EGENQGCWGT LWCWWKRSDA AQAGPSGCLR WGQAISKSKL
     SRRWRRWNRF SRRRCRAAVK SVTFYWLVIV LVFLNTLTIS SEHYNQPDWL TQVQDIANKV
     LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE TILVELEIMS PLGISVFRCV
     RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI IIFSLLGMQL FGGKFNFDES
     QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP SSSGMIVCIY FIILFICGNY
     ILLNVFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE SLENKKNHKP EVNQIANSDN
     KVIIDEYQEE DEDKDPYPPC DVPGEEEEEE EEEDEPEVPA GPRPRRISEL NMKEKIVPIP
     EGSAFFILSK TNPIRVGCHK LINHHVFTNL ILVFIMLSSA SLAAEDPIRS HSFRNTILGY
     FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML VVGVSLVSFG IQSSAISVVK
     ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV TTLLQFMFAC IGVQLFKGKF
     YRCTDEAKSN PEECRGLFIL YKDGEIDNPV VHERLWQNSD FNFDNVLSAM MALFTVSTFE
     GWPELLYKAI DSNGENVGPI YNYRVEISIF FIIYIIIVAF FMMNIFVGFV IVTFQEQGEK
     EYKNCELDKN QRQCVEYALK ARPVRRYIPK NPYQYKFWYV VNSSPFEYMM FVLIMLNTLC
     LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP KGYFSDAWNT FDSLIVIGSI
     IDVALSEADP TESENIPVPT APPGNSEESN RISITFFRLF RVMRLVKLLS RGEGIRTLLW
     TFIKSFQALP YVALLIAMLF FIYAVIGMQM FGKVAMRDNN QINRNNNFQT FPQAVLLLFR
     CATGEAWQEI MLACLPGKLC DPESDYNPGE EYSCGSNFAI VYFISFYMLC AFLIINLFVA
     VIMDNFDYLT RDWSILGPHH LDEFKRIWSE YDPEAKGRIK HLDVVTLLRR IQPPLGFGKL
     CPHRVACKRL VAMNMPLNSD GTVMFNATLF ALVRTALKIK TEGNLEQANE ELRAVIKKIW
     KKTSMKLLDQ VVPPAGDDEV TVGKFYATFL IQDYFRKFKK RKEQGLVGKY PAKNTTIALQ
     SKITFLSLLS PRLKLGLTVM GKDQCPVPMR PGTQDKRNGA LLGNHVNHVN SDRRDSLQQT
     NTTHRPLHVQ RPSVPPASDT EKPLFPPAGN SVCHNHHNHN SIGKQVPSST NANLNNANMS
     KAAGKQPSIG SLEHVSENGH DSSHKHDHEP QGRSSRKRAR YYETYIRRRS DSGDEQFPTI
     CREDPEVQGY FRDPRCLGEP EYFSGEEDYE EDSSPTSSRQ NYSYYSRHPG SSLDFERPRG
     YHHPQGFLED DDSPICYDSH RSPRRRLLPP TPTSHRRSSF NFECLRRQSS QEEVPPSPTF
     PHRTALPLHL MQQQVMAVAG LDSSRAQKYS PSHSTRSWAT PPATPPYRDW APCYTPLIQV
     EPSEVLDQVN GSLPSLHRSS WYTDEPGISY RTFTPASLTV PSSFHSKNSD KQRSADSLVE
     AVLISEGLGR YARDPKFVSA TKHEIADACD LTIDEMESAA SHLLNGTVHP GANGDVSPDS
     SRQDYELQDF GPGYSDEEPD LGREEEDLAD EMICITTL
//
DBGET integrated database retrieval system