ID G1PWF6_MYOLU Unreviewed; 1021 AA.
AC G1PWF6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Beta/gamma crystallin 'Greek key' domain-containing protein {ECO:0000259|PROSITE:PS50915};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000015726.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000015726.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000015726.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens. {ECO:0000256|ARBA:ARBA00003689}.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family.
CC {ECO:0000256|ARBA:ARBA00009646}.
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DR EMBL; AAPE02036323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02036324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02036325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PWF6; -.
DR STRING; 59463.ENSMLUP00000015726; -.
DR Ensembl; ENSMLUT00000017254.2; ENSMLUP00000015726.2; ENSMLUG00000017250.2.
DR eggNOG; ENOG502QTHR; Eukaryota.
DR GeneTree; ENSGT00940000160816; -.
DR HOGENOM; CLU_002147_1_0_1; -.
DR InParanoid; G1PWF6; -.
DR OMA; KVLNHDW; -.
DR TreeFam; TF331078; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.20.10; Crystallins; 6.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11818; BETA/GAMMA CRYSTALLIN; 1.
DR PANTHER; PTHR11818:SF123; GAMMA-CRYSTALLIN B; 1.
DR Pfam; PF00030; Crystall; 5.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00458; RICIN; 1.
DR SMART; SM00247; XTALbg; 5.
DR SUPFAM; SSF49695; gamma-Crystallin-like; 3.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 5.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Eye lens protein {ECO:0000256|ARBA:ARBA00022613};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 385..434
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 530..574
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 575..617
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 665..707
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 844..885
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT REGION 149..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 115748 MW; 23381B99B8E36A71 CRC64;
MPDFQPVDTI ERLDRRTSVT AVDNKIRNLG DGYDKREDSN LAFISQAEQE NPSFTILYEE
PLQGEDKCAP AEVRRTCPSF PDAPPGSIPV VTCERSESRT DLVHHFERGT KLGENFDSDS
SEMFLSVEAK RYKIYPLALS PIYEDDSSQE DIVSNEVSPG HHGSTKSRDN ANQPSSVLSL
LQSVSERLKM NFDEEERQEL GEEEEESLYK GSLRASRRES VAFKWTDPSS TFDSDDDQER
TGISKNLSVK AKEPTTPNLQ IGLWPEKASF LQKSDLTSKL HSSVKSAYHQ YLQTSKTHSS
EKGARFGGTL QEPASKYFRA QDNSGRLSPF IENVDIQTLR CNPRPGKIVI YDLHGSNYKQ
EVYCSILDAT SWTFPNGVLI RVVRGCWILY EKPHFQGQKC VLEEGEKVLN RDWILQNRMH
PQRNFVLGSI KRVIKDCSIP EIELCLQSDP PCCPVCIQRA VPNLEELDIP KYTSFTVKSG
VWLAYPDINF KGQATILEEG HGLFEISAAE MKSLHPLQMG GLKVEMPMNL KVIIYEKPHF
HGQAKKFSEH IDSVPNFLKN DEEFHGIGSI RVIGGVWVAY EKEHFKGQQF LLEEGDYEDR
NAYGALSGPI LSFRYLQANF IESSITLFES DLESGKFIDI KNQEISDLEE TGFGTETRSI
HVKSGVWVAY QQKFFCGEQY ILEKGKYKCF FDWGGSNNII MSIRPIQLEP LGINEPPHLL
KAFSKPGFQG ECVDFTKEIS DLTSFTPCSF KVLRGCWLLY YQEDISDNQC VLEEGLYADL
TSCGCPTSEV KSLKPIDYVF EEPSLSLFAL EHCEGRELHL EEAVNSVLNK DLHFYTQSVW
IKSGQWIAYE GSNFLGRQIL LEPNEIQNWT AFSGWKTIGS LRPMKQPAVY IRIKNRAQKE
YLTATGNAAD ARANSVCTAP YSGKNTQVWH YCRGLFKSKA SDTCLDVIGG RDTPGARVAL
WAEHGQLRQK WRLNRNGTIS SYLSDQLVLD VKGGNYYDKT HVIINQPLEG KETQKWDIEI
L
//
