ID G1PWG4_MYOLU Unreviewed; 431 AA.
AC G1PWG4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Keratin 40 {ECO:0000313|Ensembl:ENSMLUP00000015736.2};
GN Name=KRT40 {ECO:0000313|Ensembl:ENSMLUP00000015736.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000015736.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000015736.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000015736.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02029691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006095021.1; XM_006094959.1.
DR AlphaFoldDB; G1PWG4; -.
DR STRING; 59463.ENSMLUP00000015736; -.
DR Ensembl; ENSMLUT00000017264.2; ENSMLUP00000015736.2; ENSMLUG00000017258.2.
DR GeneID; 102437607; -.
DR KEGG; mlf:102437607; -.
DR CTD; 125115; -.
DR eggNOG; ENOG502SHG0; Eukaryota.
DR GeneTree; ENSGT00940000161968; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; G1PWG4; -.
DR OMA; CAASRCQ; -.
DR OrthoDB; 4640531at2759; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF90; KERATIN, TYPE I CYTOSKELETAL 40; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 89..400
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..163
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 199..226
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 298..385
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 431 AA; 47954 MW; 5FBA5794383FDCD7 CRC64;
MTSDSSPTSC SSEPHAGVSD GATASTCSTE TTGLPNTCAT SRCQTPGFLS TSRLPTTCFV
PCYLAGSCNL PCMVGNCAWC EDGVFNSNER ETMQFLNDRL ASYLERVRGL EEMNAELECR
IREQCGGDIP LVCPDYQCYF DTIEDLQRKI LCTKAENSRL TIQLDNCKLA ANDFRSKYES
ELSLRQLVET DIGGLRGILD ELTLCKADLE AQVESLKEDL LCLKKHHEEE INLLRGQLGD
RLTVELDSAP NIDLNGVLNE MRCQYETVLA NNRRDVEEWF AAQTEELNQQ QLSSAEQLQG
CQIEILELKR TANALEIELQ AQQSLTESLE CTVAETEAQY STQLAQMQCL IDNVEEQLAE
IRCDLERQNQ EYQVLLDTKA RLEGEISTYQ GLLESEDSRL PCNPCSTTSV SSNTGEPCSA
YVLCTVENCC A
//
