ID G1PXC7_MYOLU Unreviewed; 424 AA.
AC G1PXC7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Lysosomal acid phosphatase {ECO:0000256|ARBA:ARBA00039422};
DE EC=3.1.3.2 {ECO:0000256|ARBA:ARBA00012646};
GN Name=ACP2 {ECO:0000313|Ensembl:ENSMLUP00000016093.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000016093.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000016093.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000016093.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome lumen {ECO:0000256|ARBA:ARBA00004227}.
CC Lysosome membrane {ECO:0000256|ARBA:ARBA00037852}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00037852}; Lumenal side
CC {ECO:0000256|ARBA:ARBA00037852}.
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR EMBL; AAPE02024186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PXC7; -.
DR STRING; 59463.ENSMLUP00000016093; -.
DR Ensembl; ENSMLUT00000017648.2; ENSMLUP00000016093.2; ENSMLUG00000017644.2.
DR eggNOG; KOG3720; Eukaryota.
DR GeneTree; ENSGT00940000158446; -.
DR HOGENOM; CLU_030431_0_0_1; -.
DR InParanoid; G1PXC7; -.
DR OMA; QESDWPQ; -.
DR TreeFam; TF312893; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR11567:SF180; LYSOSOMAL ACID PHOSPHATASE; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
DR PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..424
FT /note="Lysosomal acid phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003417680"
FT TRANSMEM 382..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 424 AA; 48393 MW; 8D5A5C6CDC3D64E6 CRC64;
MAGGLFGWSR AALLQLLLGV NLMVMPPIQA RTLRFVTLLY RHGDRTPVKT FPKDPYQEDE
WPQGFGQLTK EGMLQHWELG QALRQRYRGF LNTSYHPQEV YVRSTDFDRT LMSAEANLAG
LFPPNGMQRF NPNISWQPIP VHTVPIAEDR LLKFPLGPCP RYEQLQNETR QTPEYQNESI
QNAQFLDMVA NETGLTDLTL ETIWNVYDTL FCEKTHGLVL PPWASPQTMQ RLSRLKDFSF
RFLFGIYEQA EKARLQGGVL LAQIRKNLTL MATSSSHLPK LLVYSAHDTT LVALQMALYV
YNGEQAPYAS CHIFELYQED NGNFSVEMYF RNESNEAPWP LSLPGCPHRC PLQDFLRLTE
SVVPKDWQQE CQLATGPADT EVIVALAVCG SILFLLIVLL LTVLFRMQAQ PPGYRHVADV
EDHA
//
