ID G1QBR7_MYOLU Unreviewed; 477 AA.
AC G1QBR7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-SEP-2017, entry version 48.
DE SubName: Full=Potassium voltage-gated channel modifier subfamily S member 2 {ECO:0000313|Ensembl:ENSMLUP00000021150};
GN Name=KCNS2 {ECO:0000313|Ensembl:ENSMLUP00000021150};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC Vespertilionidae; Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000021150, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000021150, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29
RT mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000021150}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2011) to UniProtKB.
CC -!- SIMILARITY: Belongs to the potassium channel family.
CC {ECO:0000256|SAAS:SAAS00692852}.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000021150}.
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DR EMBL; AAPE02039832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000021150; -.
DR Ensembl; ENSMLUT00000002922; ENSMLUP00000021150; ENSMLUG00000002923.
DR eggNOG; KOG3713; Eukaryota.
DR eggNOG; COG1226; LUCA.
DR GeneTree; ENSGT00760000118981; -.
DR InParanoid; G1QBR7; -.
DR OMA; VGGFKKK; -.
DR OrthoDB; EOG091G0FP3; -.
DR TreeFam; TF313103; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:1902259; P:regulation of delayed rectifier potassium channel activity; IEA:Ensembl.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR011333; SKP1/BTB/POZ.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR028325; VG_K_chnl.
DR PANTHER; PTHR11537; PTHR11537; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 3: Inferred from homology;
KW Complete proteome {ECO:0000313|Proteomes:UP000001074};
KW Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|SAAS:SAAS00417282};
KW Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW Voltage-gated channel {ECO:0000256|SAAS:SAAS00091688}.
FT TRANSMEM 188 209 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 260 281 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 332 350 Helical. {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 389 410 Helical. {ECO:0000256|SAM:Phobius}.
FT DOMAIN 17 126 BTB. {ECO:0000259|SMART:SM00225}.
SQ SEQUENCE 477 AA; 54361 MW; 11B3C152ED6BB6AC CRC64;
MTRRSLWDVS ETNVEDGDIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH SREAILELCD
DYDDVQREFY FDRNPELFPY VLHFYHTGRL HVMAELCVFS FSQEIEYWGI NEFFIDSCCS
YSYHGRKVEP AQEKWEEQSD QESTSSSFDE ILAFYNDASK FEGQPLGSFR RRLWLALDNP
GYSVLSRVFS ILSILVVLGS IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF
ELLARFAVAP DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESTPTLANL GRVAQVLRLM
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI EKEENEGLAT
IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL VVVLPITLIF NKFSHFYRRQ
KQLESAMRSC DFGDGMKEVP SVNLRDYYAH KVKSLMASLT NMNRSSPSEL SLNDSLQ
//
