ID G1QEC7_MYOLU Unreviewed; 493 AA.
AC G1QEC7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Prenylcysteine oxidase 1 like {ECO:0000313|Ensembl:ENSMLUP00000022060.1};
GN Name=PCYOX1L {ECO:0000313|Ensembl:ENSMLUP00000022060.1};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000022060.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000022060.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000022060.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRNR:PIRNR036292};
CC -!- SIMILARITY: Belongs to the prenylcysteine oxidase family.
CC {ECO:0000256|ARBA:ARBA00009967, ECO:0000256|PIRNR:PIRNR036292}.
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DR EMBL; AAPE02034302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006097492.1; XM_006097430.2.
DR AlphaFoldDB; G1QEC7; -.
DR STRING; 59463.ENSMLUP00000022060; -.
DR Ensembl; ENSMLUT00000025324.1; ENSMLUP00000022060.1; ENSMLUG00000030590.1.
DR GeneID; 102434843; -.
DR KEGG; mlf:102434843; -.
DR CTD; 78991; -.
DR eggNOG; ENOG502QSHJ; Eukaryota.
DR GeneTree; ENSGT00390000011206; -.
DR HOGENOM; CLU_021176_1_0_1; -.
DR InParanoid; G1QEC7; -.
DR OMA; NMWAVEG; -.
DR OrthoDB; 551774at2759; -.
DR TreeFam; TF329001; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0001735; F:prenylcysteine oxidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030328; P:prenylcysteine catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR010795; Prenylcys_lyase.
DR InterPro; IPR017046; Prenylcysteine_Oxase.
DR PANTHER; PTHR15944; FARNESYLCYSTEINE LYASE; 1.
DR PANTHER; PTHR15944:SF2; PRENYLCYSTEINE OXIDASE-LIKE; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR Pfam; PF07156; Prenylcys_lyase; 1.
DR PIRSF; PIRSF036292; Prenylcysteine_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRNR:PIRNR036292};
KW Flavoprotein {ECO:0000256|PIRNR:PIRNR036292};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036292};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..493
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003419969"
FT DOMAIN 120..482
FT /note="Prenylcysteine lyase"
FT /evidence="ECO:0000259|Pfam:PF07156"
SQ SEQUENCE 493 AA; 54737 MW; D1B5E0131B8EF131 CRC64;
MARAARFLAA LAALLAAAAT GGDAGPSKIA VVGAGIGGSA VTHFLQQHFG PRVQIDVFEK
GTVGGRLATI SVNKQHYESG AASFHSLSLH MQDFVKHLGL KHRREVVGRS AIFGGENFVL
EETDWYLLNL FRLWWHYGIS FLRLQMWVEE VMEKFMRIYK YQAHGYAFSG VEELLYSLGE
SSFINMTQRS VAESLLQVGV TQRFIDDIVS AVLRASYGQS AAMPAFAGAM ALAGAQGILW
SVEGGNKLVC SGLLKLTKAN VIHATVTSVT LQHTEGKPLY LVEYENEAGT SFDFYDIVVI
ATPLHLDNSS TIAFEGFDPP IDVIQDSFQP TVVSLVHGYL NSSYFGFPDP KLFPFASILT
TDFPTFFCAL DNICPVNIST NFRRKQPQEA AVWRVQSPKP LLRSQLKTLF RSYYSVQTAE
WQAHPIHGSR TTLPRFALHD QLFHLNALEW AASSVEVMAV AAKNVALLAY NRWYQDLDKI
DQKDLMHKVK TEL
//
