ID G1QEN8_MYOLU Unreviewed; 682 AA.
AC G1QEN8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000022171.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000022171.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000022171.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; AAPE02055964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02055965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QEN8; -.
DR STRING; 59463.ENSMLUP00000022171; -.
DR Ensembl; ENSMLUT00000025339.1; ENSMLUP00000022171.1; ENSMLUG00000026279.1.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000162176; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; G1QEN8; -.
DR OMA; AICCDIT; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 1..245
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 682 AA; 78141 MW; 8B0457BEEB0C1759 CRC64;
APIGQILSQP EQLLFILDNL DEPKWDLKKQ SSALCPHWSQ QQQVHTLLGS LLKKTLLPTA
SLLITARITA LRKLIPSLKH PRWVEVLGFS ESARKEYFFQ YFTDEGQAIR AFTSVESNPA
LFTMCLMPLV SWLVCTCLKQ QMEQEQPLSL TSQTTTALFL HYFFHVLQAQ SLGAKLRGLC
SLAAKGTCQR KTLFSPEDFR KYGLDEANIP ILLNMGVLQE HPTPRSYSFL HRCFQEFFAA
MSYASGDRKL KRGGFINIKT ITDLTDVYDR RDLFGEPTTC FLFGLLSDQG MRELESIFKH
SLSRKRHSYL LQLAQREVDC KHPNLEPYCW HLLHCFYENQ DTRFLTEMMS NFYGMRICVQ
THMELLVFTF CFKFCHRMKT LQLNLLCWYH RPGPWGTPTK PGPSGFMTEI TSNFFSHMVC
LRAVKDMKGK MNGVGDILGA LFWQENRDGS LQLEIEFESL SHGKEDCLHP QALCWALQIK
KMNIYALSQK NFPHSGRNRP TKGVQQCRMA RYSWGPFTDS WWQMFFSIFK VPGSLRELDL
SGNSLSCSAV QSLCDALKSP HCHLETLTLA NCGLTAEDCR VLAHVLSDNW HLIELDLSFN
KLQDTGARHL FQELTHSHCK LWWLLLVSCG LTSGCCQDLV SMLSNNVMLI VLDLQQNDLG
DLGVRLLSEG LRQSNCRLKY LG
//
