ID G1QGL0_NOMLE Unreviewed; 277 AA.
AC G1QGL0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=TNF receptor superfamily member 4 {ECO:0000313|Ensembl:ENSNLEP00000000037.1};
GN Name=TNFRSF4 {ECO:0000313|Ensembl:ENSNLEP00000000037.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000000037.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000000037.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000000037.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; ADFV01120180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01120181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003279744.1; XM_003279696.1.
DR AlphaFoldDB; G1QGL0; -.
DR STRING; 61853.ENSNLEP00000000037; -.
DR Ensembl; ENSNLET00000000040.3; ENSNLEP00000000037.1; ENSNLEG00000000032.3.
DR eggNOG; ENOG502SB1F; Eukaryota.
DR GeneTree; ENSGT00730000111452; -.
DR HOGENOM; CLU_092451_0_0_1; -.
DR InParanoid; G1QGL0; -.
DR OMA; GMVSRCS; -.
DR TreeFam; TF330135; -.
DR Proteomes; UP000001073; Chromosome 24.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR CDD; cd13406; TNFRSF4; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020445; TNFR_4.
DR InterPro; IPR034022; TNFRSF4_N.
DR PANTHER; PTHR47881; TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 4; 1.
DR PANTHER; PTHR47881:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 4; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR PRINTS; PR01921; TNFACTORR4.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF57586; TNF receptor-like; 3.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..277
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003419664"
FT TRANSMEM 214..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..64
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 30..64
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 66..107
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 66..107
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REGION 158..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 43..56
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 46..64
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 277 AA; 29337 MW; 9A691EFA6EE68FDA CRC64;
MCVGARRLGP GPCVALLLLG LGLSTATRLH CIGDTYPSND RCCNECRPGN GMVSRCSRSQ
NTVCRPCGPG YYNDVVSSKP CKSCTWCNLR SGSERKQPCT ATQDTVCRCR AGTQPLDSYK
PGVDCAPCPP GHFSPGDNQA CKPWTNCTLA GKHTLQPASN SSDAICEDRD PPATQAQETQ
GPPARPTTVQ PTEAWPRTSQ GPSTRPVDVP GGRAVAAILG LGLVLGLLGP LAILLALYLL
RRDGRLPPDA HKPPGRGSFR TPIQEEQADA HSTLAKI
//
